Lentiviral vectors bearing the cardiac promoter of the Na+ -Ca2+ exchanger report cardiogenic differentiation in stem cells

Molecular Therapy

Volumn 16, Issue 5, 2008, Pages 957-964

  Barth, Andreas S ^a   Kizana, Eddy ^a   Smith, Rachel R ^a   Terrovitis, John ^a   Dong, Peihong ^a   Leppo, Michelle K ^a   Zhang, Yiqiang ^a   Miake, Junichiro ^a   Olson, Eric N ^b   Schneider, Jay W ^c   Abraham, M Roselle ^a   Marbán, Eduardo ^d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; PARVOVIRUS VECTOR; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOSENSOR; CELL DIFFERENTIATION; CELL FATE; CELL ISOLATION; CELL SELECTION; CELL SPECIFICITY; CELL STIMULATION; CELL SUBPOPULATION; CELL THERAPY; CELL TYPE; CONTROLLED STUDY; ENRICHMENT CULTURE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; GENETIC TRANSDUCTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN EXPRESSION; RAT; SEROTYPE; STEM CELL; VALIDATION PROCESS; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALIA;

EID: 42549156555     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.30     Document Type: Article

References (27)

1. E Messina L De Angelis G Frati S Morrone S Chimenti F Fiordaliso Isolation and expansion of adult cardiac stem cells from human and murine heart Circ Res 95 2004 911 921
2. RR Smith L Barile HC Cho MK Leppo JM Hare E Messina Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens Circulation 115 2007 896 908
3. DA Taylor BZ Atkins P Hungspreugs TR Jones MC Reedy KA Hutcheson Regenerating functional myocardium: improved performance after skeletal myoblast transplantation Nat Med 4 1998 929 933
4. K Urbanek D Torella F Sheikh A De Angelis D Nurzynska F Silvestri Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure Proc Natl Acad Sci USA 102 2005 8692 8697
5. V Schächinger S Erbs A Elsässer W Haberbosch R Hambrecht H Hölschermann Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial Eur Heart J 27 2006 2775 2783
6. V Schächinger S Erbs A Elsässer W Haberbosch R Hambrecht H Hölschermann Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction N Engl J Med 355 2006 1210 1221
7. MG Klug MH Soonpaa GY Koh LJ Field Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts J Clin Invest 98 1996 216 224
8. M Müller BK Fleischmann S Selbert GJ Ji E Endl G Middeler Selection of ventricular-like cardiomyocytes from ES cells in vitro FASEB J 14 2000 2540 2548
9. CE Thomas A Ehrhardt MA Kay Progress and problems with the use of viral vectors for gene therapy Nat Rev Genet 4 2003 346 358
10. 2+ exchanger gene H1-promoter in a transgenic mouse model Circ Res 90 2002 158 164
11. A Subramaniam WK Jones J Gulick S Wert J Neumann J Robbins Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice J Biol Chem 266 1991 24613 24620
12. R Zufferey T Dull RJ Mandel A Bukovsky D Quiroz L Naldini Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery J Virol 72 1998 9873 9880
13. K Chng SR Larsen S Zhou JF Wright R Martiniello-Wilks JE Rasko Specific adeno-associated virus serotypes facilitate efficient gene transfer into human and non-human primate mesenchymal stromal cells J Gene Med 9 2007 22 32
14. JM McMahon S Conroy M Lyons U Greiser C O'shea P Strappe Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors Stem Cells Dev 15 2006 87 96
15. SA Henderson M Spencer A Sen C Kumar MA Siddiqui KR Chien Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression J Biol Chem 264 1989 18142 18148
16. R Di Lisi C Millino E Calabria F Altruda S Schiaffino S Ausoni Combinatorial cis -acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo J Biol Chem 273 1998 25371 25380
17. AC Fijnvandraat AC van Ginneken CA Schumacher KR Boheler RH Lekanne Deprez VM Christoffels Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocardium J Mol Cell Cardiol 35 2003 1461 1472
18. S Fleury E Simeoni C Zuppinger N Déglon LK von Segesser L Kappenberger Multiply attenuated, self-inactivating lentiviral vectors efficiently deliver and express genes for extended periods of time in adult rat cardiomyocytes in vivo Circulation 107 2003 2375 2382
19. L Pang G Koren Z Wang S Nattel Tissue-specific expression of two human Ca(v)1.2 isoforms under the control of distinct 5′ flanking regulatory elements FEBS Lett 546 2003 349 354
20. KJ Lee RS Ross HA Rockman AN Harris TX O'Brien' M van Bilsen Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene J Biol Chem 267 1992 15875 15885
21. T Dull R Zufferey M Kelly RJ Mandel M Nguyen D Trono A third-generation lentivirus vector with a conditional packaging system J Virol 72 1998 8463 8471
22. PJ Gruber Z Li H Li D Worrad B Huang I Abdullah In vivo imaging of MLC2v-luciferase, a cardiac-specific reporter gene expression in mice Acad Radiol 11 2004 1022 1028
23. RB Sekar E Kizana RR Smith AS Barth Y Zhang E Marbán Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity Am J Physiol Heart Circ Physiol 293 2007 H2757 H2770
24. W Cui DD Taub K Gardner qPrimerDepot: a primer database for quantitative real time PCR Nucleic Acids Res 35 2007 D805 D809
25. MW Pfaffl GW Horgan L Dempfle Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR Nucleic Acids Res 30 2002 e36
26. 2+ channels from Cav3.2 to Cav3.1 during differentiation of embryonic stem cells to cardiac cell lineage Circ J 69 2005 1284 1289
27. H Niwa J Miyazaki AG Smith Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells Nat Genet 24 2000 372 376