From ENU mutagenesis to population genetics

Mammalian Genome

Volumn 19, Issue 4, 2008, Pages 221-225

  Mitchison, N Avrion ^a   Clarke, Bryan ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; RHODOPSIN;

CAENORHABDITIS ELEGANS; CHIMPANZEE; DROSOPHILA; EVOLUTION; GENOMICS; INBREEDING; KNOCKOUT MOUSE; MUTAGENESIS; NATURAL SELECTION; NONHUMAN; NOTE; POPULATION GENETICS; PSYCHOMETRY;

ANIMALS; ETHYLNITROSOUREA; GENES, DOMINANT; GENETIC TECHNIQUES; GENETICS, POPULATION; GENOME, HUMAN; HUMANS; MUTAGENESIS;

EID: 42449154579     PISSN: 09388990     EISSN: 14321777     Source Type: Journal    
DOI: 10.1007/s00335-008-9104-2     Document Type: Note

References (40)

1. Barbaric I, Wells S, Russ A, Dear TN (2007) Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse. Environ Mol Mutagen 48:124-142
2. Blagosklonny MV (2000) p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect. FASEB J 14:1901-1907
3. Charlesworth J, Eyre-Walker A (2007) The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations. Proc Natl Acad Sci U S A 104:16992-16997
4. Clark AT, Goldwitz D, Takahashi JS, Vitatema MH, Siepka SM et al (2004) Implementing large-scale ENU mutagenesis screens in North America. Genetica 122:51-64
5. Cook MC, Vinuesa CG, Goodnow CC (2006) ENU-mutagenesis: insight into immune function and pathology. Curr Opin Immunol 18:627-633
6. Cook MN, Dunning JP, Wiley RG, Chesler EJ, Johnson DK et al (2007) Neurobehavioral mutants identified in an ENU-mutagenesis project. Mamm Genome 18:559-572
7. Daiger SP, Bowne SJ, Sullivan LS (2007) Perspective on genes and mutations causing retinitis pigmentosa. Arch Ophthalmol 125:151-158
8. Eades-Perner AM, Gathmann B, Knerr V, Guzman D, Veit D et al (2007) The European internet-based patient and research database for primary immunodeficiencies: results 2004-06. Clin Exp Immunol 147:306-312
9. Edmands S (2007) Between a rock and a hard place: evaluating the relative risks of inbreeding and outbreeding for conservation and management. Mol Ecol 16:463-475
10. Eyre-Walker A, Keightley PD (2007) The distribution of fitness effects of new mutations. Nat Rev Genet 8:610-618
11. Falconer DS (1989) Introduction to Quantitative Genetics, 3rd edn. Longmann, London
12. Furney SJ, Alba MM, Lopez-Bigas N (2006) Differences in the evolutionary history of disease genes affected by dominant or recessive mutations. BMC Genomics 7:165
13. Godinho SI, Nolan PM (2006) The role of mutagenesis in defining genes in behaviour. Eur J Hum Genet 14:651-659
14. Hawks J, Hunley K, Lee SH, Wolpoff M (2000) Population bottlenecks and Pleistocene human evolution. Mol Biol Evol 17:2-22
15. Hoyne GF, Goodnow CC (2006) The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunol Rev 210:27-39
16. Hrabé de Angelis MH, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D et al (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 25:444-447
17. Hurst LD, Randerson JP (2000) Dosage, deletions and dominance: simple models of the evolution of gene expression. J Theor Biol 205:641-647
18. Jablonski MM, Wang X, Lu L, Miller DR, Rinchik EM et al (2005) The Tennessee Mouse Genome Consortium: identification of ocular mutants. Vis Neurosci 22:595-604
19. Jimenez-Sanchez G, Childs B, Valle D (2001) Human disease genes. Nature 409:853-855
20. Johnston JA, Ward CL, Kopito RR (1998) Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143:1883-1898
21. Justice MJ, Noveroske JK, Weber JS, Zheng B, Bradley A (1999) Mouse ENU mutagenesis. Hum Mol Genet 8:1955-1963
22. Kafri R, Levy M, Pilpel Y (2006) The regulatory utilization of genetic redundancy through responsive backup circuits. Proc Natl Acad Sci U S A 103:11653-11658
23. Keightley PD (1994) The distribution of mutation effects on viability in Drosophila melanogaster. Genetics 138:1315-1322
24. Kondrashov FA, Koonin EV (2004) A common framework for understanding the origin of genetic dominance and evolutionary fates of gene duplications. Trends Genet 20:287-290
25. Lopez-Bigas N, Blencowe BJ, Ouzounis CA (2006) Highly consistent patterns for inherited human diseases at the molecular level. Bioinformatics 22:269-277
26. Lynch M, Conery JS (2000) The evolutionary fate and consequences of duplicate genes. Science 290:1151-1155
27. Masuya H, Nakai Y, Motegi H, Niinaya N, Kida Y et al (2004) Development and implementation of a database system to manage a large-scale mouse ENU-mutagenesis program. Mamm Genome 15:404-411
28. Mendes HF, van der Spuy J, Chapple JP, Cheetham ME (2005) Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy. Trends Mol Med 11:177-185
29. Mitchell-Olds T, Willis JH, Goldstein DB (2007) Which evolutionary processes influence natural genetic variation for phenotypic traits? Nat Rev Genet 8:845-856
30. Nielsen R, Bustamante C, Clarke AG, Glanowski S, Sackton TB et al (2005) A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol 3:e170
31. Nielsen R, Hellmann I, Hubisz M, Bustamante C, Clark AG (2007) Recent and ongoing selection in the human genome. Nat Rev Genet 8:857-868
32. Nolan PM, Peters J, Strivens M, Rogers D, Hagan J et al (2000) A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 25:440-443
33. Pinto LH, Vitatema MH, Siepka SM, Shimomura K, Lumayag S et al (2004) Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus. Vision Res 44:3335-3345
34. Reijmers LG, Coats JK, Pletcher MT, Wiltshire T, Tarantino LM et al (2006) A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Learn Mem 13:143-149
35. Seidman JG, Seidman C (2002) Transcription factor haploinsufficiency: when half a loaf is not enough. J Clin Invest 109:451-455
36. Takahasi KR, Sakuraba Y, Gondo Y (2007) Mutational pattern and frequency of induced nucleotide changes in mouse ENU mutagenesis. BMC Mol Biol 8:52
37. The Mouse Phenotype Database Integration Consortium (2007) Integration of mouse phenome data resources. Mamm Genome 18:157-163
38. Tirosh I, Bilu Y, Barkai N (2007) Comparative biology: beyond sequence analysis. Curr Opin Biotechnol 18:371-377
39. Vihinen M, Arredondo-Vega FX, Casanova JL, Etzioni A, Giliani S et al (2001) Primary immunodeficiency mutation databases. Adv Genet 43:103-188
40. Williamson SH, Hernandez R, Fledel-Alon A, Zhu L, Nielsen R et al (2005) Simultaneous inference of selection and population growth from patterns of variation in the human genome. Proc Natl Acad Sci U S A 102:7882-7887