Gastroprotective effects of aqueous extract of Adansonia digitata leaf on ethanol-induced ulceration in rats

Journal of Biological Sciences

Volumn 8, Issue 1, 2008, Pages 225-228

  Karumi, Y ^a   Augustine, A I ^a   Umar, I A ^b  

^a UNIVERSITY OF MAIDUGURI   (Nigeria)

^b AHMADU BELLO UNIVERSITY   (Nigeria)

Author keywords

Adansonia digitata; Ethanol; Gastroprotective; Ulceration

Indexed keywords

ADANSONIA DIGITATA EXTRACT; ALCOHOL; ASTRINGENT AGENT; FLAVANOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; MALE; NONHUMAN; RAT; STOMACH PROTECTION; STOMACH ULCER;

ADANSONIA DIGITATA; RATTUS;

EID: 42449148276     PISSN: 17273048     EISSN: 18125719     Source Type: Journal    
DOI: 10.3923/jbs.2008.225.228     Document Type: Article

References (17)

1. Alpin, R.S. and J.W. Ward, 1967. Action of hexopyronium bromide on gastric secretion and in dogs and on gastric secretion and ulceration in rats. Arch. Int. Pharmaelyn, 168 (1): 82-100.
2. Arrigori, O. and M.C. De Tullio, 2002. Ascobic acid: Much more than just an anti oxidant. Biochem. Biophys. Acta, 1569 (1-3): 1-9.
3. Bagchi D., O. Carry, W. Tran, T. Krolin, D.J. Bagchi, A. Gary, M. Bagchi, S. Mitra and S. Stohs, 1998. Stress, diet and alcohol induced oxidation, gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate. J. Applied Toxicol., 18 (1): 3-13.
4. El-Khalifa, 1999. Folk medicinal plants of riverside forest of the Southern Blue Nile district, Sudan. Fitoterapia, 70: 493-497.
5. Evbuoman, M.I. and A.F. Bolarinwa, 1990. Effect of diet on indomethecin-induced peptic ulceration in pregnant rats. Nig. J. Physiol. Sci., 6: 187-191.
6. Hernandez, R. Munoz, C. Montel Ruiz and Vazquez O. Martinez, 2000. Gastric mucosal cell proliferation in ethanol-induced chronic mucosal injury is related to oxidative stress and lipid peroxidation in rats. Lab. Invest., 80 (8): 1161-1169.
7. Hirokawa, M., S. Miura, H. Yoshida, I. Kurose, T. Shige Matsu, H. Hokari, S. Kato and H. Ishii, 1998. Oxidation stress and mitochondrial damage produces gastric mucosal cell death induced by ethanol administration. Alcoholism Clin. Exp. Res., 22 (3): 111s-114s.
8. Karumi, Y., P.O. Onyeyil and V.O. Ogugbuaja, 2003. Anti-inflammatory and Antinociceptive (Analgesic) properties of Momordica balsamina Linn. (Balsam Apple) leaves in rats. Pak. J. Biol. Sci., 6 (17): 1515-1518.
9. Lucas, G.L., 1971. The baobab map project with Bot. Staatssammi, Munchen, 10: 162-164.
10. Mittal, G.C., C.N. Aguwa, V.W. Ezein and P.I. Akubue, 1981. Preliminary Pharmacological studies on anti-venom action of Diodia Scandens leaves. Nig. J. Pharm., 12: 432-436.
11. Nwafor, P.A., K.D Effraim and T.W. Jacks, 1996. Gastroprotective effects of Aqueous extract of Kaya sinegalensis on indomethecin induced ulceration in rats. West Afr. J. Pharmacol. Drug. Res., 12: 45-50.
12. Penissi, A. and R. Piezzi, 1999. Effect of dehydroleucodine on mucus production. A quantitative study. Digestion, Dis. Sci., 44 (4): 708-712.
13. Ramadan, F.M., S.A. Harraz and El-mougy, 1994. Anti-inflammatory, analgesic and Anti-pyretic effects of the fruit pulp of Adansonia digitata. Fitoteropia, 65 (5): 418-422.
14. Tal-Dia, A., K. Toure, M. Sarr, M.F. Cisse, P. Garmier and I. Wone, 1974. A baobab solution for the prevention and treatment of acute dehydration in infantile diarrhea. Dakar Med., 42 (1): 68-73.
15. WHO., 1992. Quality control method for medicinal plant materials WHO Genewa, pp: 26.
16. Wood Ruff, B.C., 1969. Baobab Africa's tree of legend, myth and mystery. Sunday News may (Tanzania) June 22, pp: 7-8.
17. Zaidi, S.H. and B. Mukerji, 1958. Experimental peptic ulceration. Ind. J. Med. Res., 46: 27-37.