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Volumn 87, Issue 3, 2008, Pages 129-141

NMDA receptor subunit NR2b: Effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol

Author keywords

Estrogen; Glutamate, N methyl D aspartate receptor; GnRH mRNA; Gonadotropin releasing hormone; Ifenprodil; Luteinizing hormone; NR2b; Reproductive aging; Reproductive senescence

Indexed keywords

CHOLESTEROL; ESTRADIOL; GLUTAMATE RECEPTOR; GONADORELIN; IFENPRODIL; LUTEINIZING HORMONE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

EID: 42449139083     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111136     Document Type: Article
Times cited : (18)

References (70)
  • 1
    • 29944445370 scopus 로고    scopus 로고
    • Regulatory role of excitatory amino acids in reproduction
    • Mahesh VB, Brann DW: Regulatory role of excitatory amino acids in reproduction. Endocrine 2005;28:271-280.
    • (2005) Endocrine , vol.28 , pp. 271-280
    • Mahesh, V.B.1    Brann, D.W.2
  • 2
    • 0036720582 scopus 로고    scopus 로고
    • N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat
    • Miller BH, Gore AC: N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat. Endocrinology 2002;143:3568-3574.
    • (2002) Endocrinology , vol.143 , pp. 3568-3574
    • Miller, B.H.1    Gore, A.C.2
  • 3
    • 0029843862 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone and NMDA receptor gene expression and colocalization change during puberty in female rats
    • Gore AC, Wu TJ, Rosenberg JJ, Roberts JL: Gonadotropin-releasing hormone and NMDA receptor gene expression and colocalization change during puberty in female rats. J Neurosci 1996;16:5281-5289.
    • (1996) J Neurosci , vol.16 , pp. 5281-5289
    • Gore, A.C.1    Wu, T.J.2    Rosenberg, J.J.3    Roberts, J.L.4
  • 4
    • 33644868071 scopus 로고    scopus 로고
    • Bailey JD, Centers A, Jennes L: Expression of AMPA receptor subunits (GluR1-GluR4) in gonadotrophin-releasing hormone neurones of young and middle-aged persistently oestrous rats during the steroid-induced luteinising hormone surge. J Neuroendocrinol 2006;18:1-12.
    • Bailey JD, Centers A, Jennes L: Expression of AMPA receptor subunits (GluR1-GluR4) in gonadotrophin-releasing hormone neurones of young and middle-aged persistently oestrous rats during the steroid-induced luteinising hormone surge. J Neuroendocrinol 2006;18:1-12.
  • 5
    • 0028927458 scopus 로고
    • Effect of NMDA and non-NMDA receptor antagonists on pulsatile luteinizing hormone secretion in the adult male rat
    • Ping L, Mahesh VB, Brann DW: Effect of NMDA and non-NMDA receptor antagonists on pulsatile luteinizing hormone secretion in the adult male rat. Neuroendocrinology 1995;61:226-234.
    • (1995) Neuroendocrinology , vol.61 , pp. 226-234
    • Ping, L.1    Mahesh, V.B.2    Brann, D.W.3
  • 6
    • 0017166731 scopus 로고
    • The effects of neurally active amino acids on pituitary gonadotropin secretion
    • Ondo JG, Pass KA, Baldwin R: The effects of neurally active amino acids on pituitary gonadotropin secretion. Neuroendocrinology 1976;21:79-87.
    • (1976) Neuroendocrinology , vol.21 , pp. 79-87
    • Ondo, J.G.1    Pass, K.A.2    Baldwin, R.3
  • 7
    • 0025122139 scopus 로고
    • Glutamate receptors of the non-N-methyl-D-aspartic acid type mediate the increase in luteinizing hormone-releasing hormone release by excitatory amino acids in vitro
    • Donoso AO, Lopez FJ, Negro-Vilar A: Glutamate receptors of the non-N-methyl-D-aspartic acid type mediate the increase in luteinizing hormone-releasing hormone release by excitatory amino acids in vitro. Endocrinology 1990;126:414-420.
    • (1990) Endocrinology , vol.126 , pp. 414-420
    • Donoso, A.O.1    Lopez, F.J.2    Negro-Vilar, A.3
  • 8
    • 0026539582 scopus 로고
    • Excitatory amino acid regulation of gonadotropin secretion: Modulation by steroid hormones
    • Brann DW, Mahesh VB: Excitatory amino acid regulation of gonadotropin secretion: modulation by steroid hormones. J Steroid Biochem Mol Biol 1992;41:847-850.
    • (1992) J Steroid Biochem Mol Biol , vol.41 , pp. 847-850
    • Brann, D.W.1    Mahesh, V.B.2
  • 9
    • 0024392948 scopus 로고
    • Pulsatile release of gonadotropin-releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L-aspartate receptors
    • Bourguignon JP, Gerard A, Mathieu J, Simons J, Franchimont P: Pulsatile release of gonadotropin-releasing hormone from hypothalamic explants is restrained by blockade of N-methyl-D,L-aspartate receptors. Endocrinology 1989;125:1090-1096.
    • (1989) Endocrinology , vol.125 , pp. 1090-1096
    • Bourguignon, J.P.1    Gerard, A.2    Mathieu, J.3    Simons, J.4    Franchimont, P.5
  • 10
    • 0023935716 scopus 로고    scopus 로고
    • Arslan M, Pohl CR, Plant TM: D,L-2-Amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat. Neuroendocrinology 1988;47:465-468.
    • Arslan M, Pohl CR, Plant TM: D,L-2-Amino-5-phosphonopentanoic acid, a specific N-methyl-D-aspartic acid receptor antagonist, suppresses pulsatile LH release in the rat. Neuroendocrinology 1988;47:465-468.
  • 11
    • 0028275714 scopus 로고
    • A physiological role for N-methyl-D-aspartic acid and non-N-methyl-D- aspartic acid receptors in pulsatile gonadotropin secretion in the adult female rat
    • Ping L, Mahesh VB, Brann DW: A physiological role for N-methyl-D-aspartic acid and non-N-methyl-D- aspartic acid receptors in pulsatile gonadotropin secretion in the adult female rat. Endocrinology 1994;135:113-118.
    • (1994) Endocrinology , vol.135 , pp. 113-118
    • Ping, L.1    Mahesh, V.B.2    Brann, D.W.3
  • 12
    • 0031594725 scopus 로고    scopus 로고
    • Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-D- aspartate
    • Bonavera JJ, Swerdloff RS, Sinha Hakim AP, Lue YH, Wang C: Aging results in attenuated gonadotropin releasing hormone-luteinizing hormone axis responsiveness to glutamate receptor agonist N-methyl-D- aspartate. J Neuroendocrinol 1998;10:93-99.
    • (1998) J Neuroendocrinol , vol.10 , pp. 93-99
    • Bonavera, J.J.1    Swerdloff, R.S.2    Sinha Hakim, A.P.3    Lue, Y.H.4    Wang, C.5
  • 13
    • 0027161942 scopus 로고
    • Estradiol modulates the LH release response to N-methyl-D-aspartate in adult female rats: Studies on hypothalamic luteinizing hormone-releasing hormone and neurotransmitter release
    • Arias P, Jarry H, Leonhardt S, Moguilevsky JA, Wuttke W: Estradiol modulates the LH release response to N-methyl-D-aspartate in adult female rats: studies on hypothalamic luteinizing hormone-releasing hormone and neurotransmitter release. Neuroendocrinology 1993;57:710-715.
    • (1993) Neuroendocrinology , vol.57 , pp. 710-715
    • Arias, P.1    Jarry, H.2    Leonhardt, S.3    Moguilevsky, J.A.4    Wuttke, W.5
  • 15
    • 0019433263 scopus 로고
    • Pulsatile LH release during the ovulatory LH surge on proestrus in the rat
    • Gallo RV: Pulsatile LH release during the ovulatory LH surge on proestrus in the rat. Biol Reprod 1981;24:100-104.
    • (1981) Biol Reprod , vol.24 , pp. 100-104
    • Gallo, R.V.1
  • 16
    • 0020394176 scopus 로고
    • Regulation of luteinizing hormone pulse frequency and amplitude by testosterone in the adult male rat
    • Steiner RA, Bremner WJ, Clifton DK: Regulation of luteinizing hormone pulse frequency and amplitude by testosterone in the adult male rat. Endocrinology 1982;111:2055-2061.
    • (1982) Endocrinology , vol.111 , pp. 2055-2061
    • Steiner, R.A.1    Bremner, W.J.2    Clifton, D.K.3
  • 17
    • 0018168286 scopus 로고
    • Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone
    • Belchetz PE, Plant TM, Nakai Y, Keogh EJ, Knobil E: Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone. Science 1978;202:631-633.
    • (1978) Science , vol.202 , pp. 631-633
    • Belchetz, P.E.1    Plant, T.M.2    Nakai, Y.3    Keogh, E.J.4    Knobil, E.5
  • 18
    • 3643058805 scopus 로고
    • Cyclical changes in the vaginal smears of senile nulliparous and multiparous rats
    • Mandl AM: Cyclical changes in the vaginal smears of senile nulliparous and multiparous rats. J Endocrinol 1961;22:257-268.
    • (1961) J Endocrinol , vol.22 , pp. 257-268
    • Mandl, A.M.1
  • 19
    • 0016832464 scopus 로고
    • Reproductive capacity of aging female rats
    • Huang HH, Meites J: Reproductive capacity of aging female rats. Neuroendocrinology 1975;17:289-295.
    • (1975) Neuroendocrinology , vol.17 , pp. 289-295
    • Huang, H.H.1    Meites, J.2
  • 20
    • 0018182449 scopus 로고
    • Patterns of sex steroid and gonadotropin secretion in aging female rats
    • Huang HH, Steger RW, Bruni JF, Meites J: Patterns of sex steroid and gonadotropin secretion in aging female rats. Endocrinology 1978;103:1855-1859.
    • (1978) Endocrinology , vol.103 , pp. 1855-1859
    • Huang, H.H.1    Steger, R.W.2    Bruni, J.F.3    Meites, J.4
  • 21
    • 0018889320 scopus 로고
    • Alteration in pulsatile release of LH in aging female rats
    • Estes KS, Simpkins JW, Chen CL: Alteration in pulsatile release of LH in aging female rats. Proc Soc Exp Biol Med 1980;163:384-387.
    • (1980) Proc Soc Exp Biol Med , vol.163 , pp. 384-387
    • Estes, K.S.1    Simpkins, J.W.2    Chen, C.L.3
  • 22
    • 0020731767 scopus 로고
    • Diminished luteinizing hormone pulse frequency and amplitude with aging in the male rat
    • Karpas AE, Bremner WJ, Clifton DK, Steiner RA, Dorsa DM: Diminished luteinizing hormone pulse frequency and amplitude with aging in the male rat. Endocrinology 1983;112:788-792.
    • (1983) Endocrinology , vol.112 , pp. 788-792
    • Karpas, A.E.1    Bremner, W.J.2    Clifton, D.K.3    Steiner, R.A.4    Dorsa, D.M.5
  • 23
    • 0025062618 scopus 로고
    • Age-related changes in pulsatile luteinizing hormone release precede the transition to estrous acyclicity and depend upon estrous cycle history
    • Scarbrough K, Wise PM: Age-related changes in pulsatile luteinizing hormone release precede the transition to estrous acyclicity and depend upon estrous cycle history. Endocrinology 1990;126:884-890.
    • (1990) Endocrinology , vol.126 , pp. 884-890
    • Scarbrough, K.1    Wise, P.M.2
  • 24
    • 84882878502 scopus 로고    scopus 로고
    • Age-related changes in hormones and their receptors in animal models of female reproductive senescence
    • Conn PM ed, New York, Academic Press
    • Maffucci JA, Gore AC: Age-related changes in hormones and their receptors in animal models of female reproductive senescence; in Conn PM (ed): Handbook of Models for the Study of Human Aging. New York, Academic Press, 2006.
    • (2006) Handbook of Models for the Study of Human Aging
    • Maffucci, J.A.1    Gore, A.C.2
  • 25
    • 0028943413 scopus 로고
    • The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats
    • Funabashi T, Kimura F: The number of luteinizing hormone-releasing hormone immunoreactive neurons is significantly decreased in the forebrain of old-aged female rats. Neurosci Lett 1995;189:85-88.
    • (1995) Neurosci Lett , vol.189 , pp. 85-88
    • Funabashi, T.1    Kimura, F.2
  • 26
    • 0034522842 scopus 로고    scopus 로고
    • Neuroendocrine aging in the female rat: The changing relationship of hypothalamic gonadotropin-releasing hormone neurons and N-methyl-D receptors
    • Gore AC, Yeung G, Morrison JH, Oung T: Neuroendocrine aging in the female rat: the changing relationship of hypothalamic gonadotropin-releasing hormone neurons and N-methyl-D receptors. Endocrinology 2000;141:4757-4767.
    • (2000) Endocrinology , vol.141 , pp. 4757-4767
    • Gore, A.C.1    Yeung, G.2    Morrison, J.H.3    Oung, T.4
  • 27
    • 0028144387 scopus 로고
    • The number and distribution of detectable luteinizing hormone (LH)-releasing hormone cell bodies changes in association with the preovulatory LH surge in the brains of young but not middle-aged female rats
    • Rubin BS, King JC: The number and distribution of detectable luteinizing hormone (LH)-releasing hormone cell bodies changes in association with the preovulatory LH surge in the brains of young but not middle-aged female rats. Endocrinology 1994;134:467-474.
    • (1994) Endocrinology , vol.134 , pp. 467-474
    • Rubin, B.S.1    King, J.C.2
  • 28
    • 24944487970 scopus 로고    scopus 로고
    • Attenuation of preoptic area glutamate release correlates with reduced luteinizing hormone secretion in middle-aged female rats
    • Neal-Perry GS, Zeevalk GD, Santoro NF, Etgen AM: Attenuation of preoptic area glutamate release correlates with reduced luteinizing hormone secretion in middle-aged female rats. Endocrinology 2005;146:4331-4339.
    • (2005) Endocrinology , vol.146 , pp. 4331-4339
    • Neal-Perry, G.S.1    Zeevalk, G.D.2    Santoro, N.F.3    Etgen, A.M.4
  • 29
    • 0037229675 scopus 로고    scopus 로고
    • Colocalization and hormone regulation of estrogen receptor α and N-methyl-D-aspartate receptor in the hypothalamus of female rats
    • Chakraborty TR, Ng L, Gore AC: Colocalization and hormone regulation of estrogen receptor α and N-methyl-D-aspartate receptor in the hypothalamus of female rats. Endocrinology 2003;144:299-305.
    • (2003) Endocrinology , vol.144 , pp. 299-305
    • Chakraborty, T.R.1    Ng, L.2    Gore, A.C.3
  • 30
    • 0142126332 scopus 로고    scopus 로고
    • Stereologic analysis of estrogen receptor α expression in rat hypothalamus and its regulation by aging and estrogen
    • Chakraborty TR, Hof PR, Ng L, Gore AC: Stereologic analysis of estrogen receptor α expression in rat hypothalamus and its regulation by aging and estrogen. J Comp Neurol 2003;466:409-421.
    • (2003) J Comp Neurol , vol.466 , pp. 409-421
    • Chakraborty, T.R.1    Hof, P.R.2    Ng, L.3    Gore, A.C.4
  • 31
    • 0036205864 scopus 로고    scopus 로고
    • Age-related changes in hypothalamic gonadotropin-releasing hormone and N-methyl-D-aspartate receptor gene expression, and their regulation by oestrogen, in the female rat
    • Gore AC, Oung T, Woller MJ: Age-related changes in hypothalamic gonadotropin-releasing hormone and N-methyl-D-aspartate receptor gene expression, and their regulation by oestrogen, in the female rat. J Neuroendocrinol 2002;14:300-309.
    • (2002) J Neuroendocrinol , vol.14 , pp. 300-309
    • Gore, A.C.1    Oung, T.2    Woller, M.J.3
  • 32
    • 0035663901 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone neurons, NMDA receptors, and their regulation by steroid hormones across the reproductive life cycle
    • Gore AC: Gonadotropin-releasing hormone neurons, NMDA receptors, and their regulation by steroid hormones across the reproductive life cycle. Brain Res Brain Res Rev 2001;37:235-248.
    • (2001) Brain Res Brain Res Rev , vol.37 , pp. 235-248
    • Gore, A.C.1
  • 33
    • 0033343013 scopus 로고    scopus 로고
    • Perinatal changes in hypothalamic N-methyl-D-aspartate receptors and their relationship to gonadotropin-releasing hormone neurons
    • Adams MM, Flagg RA, Gore AC: Perinatal changes in hypothalamic N-methyl-D-aspartate receptors and their relationship to gonadotropin-releasing hormone neurons. Endocrinology 1999;140:2288-2296.
    • (1999) Endocrinology , vol.140 , pp. 2288-2296
    • Adams, M.M.1    Flagg, R.A.2    Gore, A.C.3
  • 35
    • 0003633755 scopus 로고    scopus 로고
    • National Research Council:, Washington, National Academies Press
    • National Research Council: Guide for the Care and Use of Laboratory Animals. Washington, National Academies Press, 1996.
    • (1996) Guide for the Care and Use of Laboratory Animals
  • 36
    • 0034879250 scopus 로고    scopus 로고
    • Length of postovariectomy interval and age, but not estrogen replacement, regulate N-methyl-D-aspartate receptor mRNA levels in the hippocampus of female rats
    • Adams MM, Oung T, Morrison JH, Gore AC: Length of postovariectomy interval and age, but not estrogen replacement, regulate N-methyl-D-aspartate receptor mRNA levels in the hippocampus of female rats. Exp Neurol 2001;170:345-356.
    • (2001) Exp Neurol , vol.170 , pp. 345-356
    • Adams, M.M.1    Oung, T.2    Morrison, J.H.3    Gore, A.C.4
  • 37
    • 0031768532 scopus 로고    scopus 로고
    • The synergistic effects of combining cocaine and heroin ('speedball') using a progressive-ratio schedule of drug reinforcement
    • Duvauchelle CL, Sapoznik T, Kornetsky C: The synergistic effects of combining cocaine and heroin ('speedball') using a progressive-ratio schedule of drug reinforcement. Pharmacol Biochem Behav 1998;61:297-302.
    • (1998) Pharmacol Biochem Behav , vol.61 , pp. 297-302
    • Duvauchelle, C.L.1    Sapoznik, T.2    Kornetsky, C.3
  • 38
    • 0034604819 scopus 로고    scopus 로고
    • Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence
    • Narita M, Soma M, Mizoguchi H, Tseng LF, Suzuki T: Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence. Eur J Pharmacol 2000;401:191-195.
    • (2000) Eur J Pharmacol , vol.401 , pp. 191-195
    • Narita, M.1    Soma, M.2    Mizoguchi, H.3    Tseng, L.F.4    Suzuki, T.5
  • 39
    • 0035449320 scopus 로고    scopus 로고
    • Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning
    • Rodrigues SM, Schafe GE, LeDoux JE: Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning. J Neurosci 2001;21:6889-6896.
    • (2001) J Neurosci , vol.21 , pp. 6889-6896
    • Rodrigues, S.M.1    Schafe, G.E.2    LeDoux, J.E.3
  • 40
    • 0026508835 scopus 로고
    • Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals
    • Jakubowski M, Roberts JL: Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals. J Neuroendocrinol 1992;4:79-89.
    • (1992) J Neuroendocrinol , vol.4 , pp. 79-89
    • Jakubowski, M.1    Roberts, J.L.2
  • 41
    • 0034657845 scopus 로고    scopus 로고
    • The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models
    • Medhurst AD, Harrison DC, Read SJ, Campbell CA, Robbins MJ, Pangalos MN: The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models. J Neurosci Meth 2000;98:9-20.
    • (2000) J Neurosci Meth , vol.98 , pp. 9-20
    • Medhurst, A.D.1    Harrison, D.C.2    Read, S.J.3    Campbell, C.A.4    Robbins, M.J.5    Pangalos, M.N.6
  • 42
    • 0028206880 scopus 로고
    • Regulation of gonadotropin-releasing hormone gene expression by the excitatory amino acids kainic acid and N-methyl-D, L-aspartate in the male rat
    • Gore AC, Roberts JL: Regulation of gonadotropin-releasing hormone gene expression by the excitatory amino acids kainic acid and N-methyl-D, L-aspartate in the male rat. Endocrinology 1994;134:2026-2031.
    • (1994) Endocrinology , vol.134 , pp. 2026-2031
    • Gore, A.C.1    Roberts, J.L.2
  • 43
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 44
    • 0022447036 scopus 로고
    • Cluster analysis: A simple, versatile, and robust algorithm for endocrine pulse detection
    • Veldhuis JD, Johnson ML: Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection. Am J Physiol 1986;250:E486-E493.
    • (1986) Am J Physiol , vol.250
    • Veldhuis, J.D.1    Johnson, M.L.2
  • 45
    • 0027537250 scopus 로고
    • Differential gonadotropin responses to N-methyl-D,L-aspartate in metestrous, proestrous, and ovariectomized rats
    • Luderer U, Strobl FJ, Levine JE, Schwartz NB: Differential gonadotropin responses to N-methyl-D,L-aspartate in metestrous, proestrous, and ovariectomized rats. Biol Reprod 1993;48:857-866.
    • (1993) Biol Reprod , vol.48 , pp. 857-866
    • Luderer, U.1    Strobl, F.J.2    Levine, J.E.3    Schwartz, N.B.4
  • 46
    • 0034463040 scopus 로고    scopus 로고
    • N-Methyl-D,L-aspartate induces the release of luteinizing hormone-releasing hormone in the prepubertal and pubertal female rhesus monkey as measured by in vivo push-pull perfusion in the stalk-median eminence
    • Claypool LE, Kasuya E, Saitoh Y, Marzban F, Terasawa E: N-Methyl-D,L-aspartate induces the release of luteinizing hormone-releasing hormone in the prepubertal and pubertal female rhesus monkey as measured by in vivo push-pull perfusion in the stalk-median eminence. Endocrinology 2000;141:219-228.
    • (2000) Endocrinology , vol.141 , pp. 219-228
    • Claypool, L.E.1    Kasuya, E.2    Saitoh, Y.3    Marzban, F.4    Terasawa, E.5
  • 47
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl- D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • Williams K: Ifenprodil discriminates subtypes of the N-methyl- D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol 1993;44:851-859.
    • (1993) Mol Pharmacol , vol.44 , pp. 851-859
    • Williams, K.1
  • 48
    • 0034845914 scopus 로고    scopus 로고
    • Ifenprodil, a novel NMDA receptor antagonist: Site and mechanism of action
    • Williams K: Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action. Curr Drug Targets 2001;2:285-298.
    • (2001) Curr Drug Targets , vol.2 , pp. 285-298
    • Williams, K.1
  • 52
    • 0030792335 scopus 로고    scopus 로고
    • Expression of glutamate receptor subunit mRNAs in gonadotropin-releasing hormone neurons during the sexual maturation of the female rat
    • Eyigor O, Jennes L: Expression of glutamate receptor subunit mRNAs in gonadotropin-releasing hormone neurons during the sexual maturation of the female rat. Neuroendocrinology 1997;66:122-129.
    • (1997) Neuroendocrinology , vol.66 , pp. 122-129
    • Eyigor, O.1    Jennes, L.2
  • 53
    • 0028012584 scopus 로고
    • Glutamate receptors in the rat hypothalamus and pituitary
    • Meeker RB, Greenwood RS, Hayward JN: Glutamate receptors in the rat hypothalamus and pituitary. Endocrinology 1994;134:621-629.
    • (1994) Endocrinology , vol.134 , pp. 621-629
    • Meeker, R.B.1    Greenwood, R.S.2    Hayward, J.N.3
  • 54
    • 0034601221 scopus 로고    scopus 로고
    • Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat
    • Herman JP, Eyigor O, Ziegler DR, Jennes L: Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat. J Comp Neurol 2000;422:352-362.
    • (2000) J Comp Neurol , vol.422 , pp. 352-362
    • Herman, J.P.1    Eyigor, O.2    Ziegler, D.R.3    Jennes, L.4
  • 55
    • 0031737964 scopus 로고    scopus 로고
    • Evidence for terminal regulation of GnRH release by excitatory amino acids in the median eminence in female rats: A dual immunoelectron microscopic study
    • Kawakami SI, Hirunagi K, Ichikawa M, Tsukamura H, Maeda KI: Evidence for terminal regulation of GnRH release by excitatory amino acids in the median eminence in female rats: a dual immunoelectron microscopic study. Endocrinology 1998;139:1458-1461.
    • (1998) Endocrinology , vol.139 , pp. 1458-1461
    • Kawakami, S.I.1    Hirunagi, K.2    Ichikawa, M.3    Tsukamura, H.4    Maeda, K.I.5
  • 57
    • 17444426068 scopus 로고    scopus 로고
    • Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
    • Hatton CJ, Paoletti P: Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron 2005;46:261-274.
    • (2005) Neuron , vol.46 , pp. 261-274
    • Hatton, C.J.1    Paoletti, P.2
  • 58
    • 0021812842 scopus 로고
    • Glutamic acid decarboxylase-containing axons synapse on LHRH neurons in the rat medial preoptic area
    • Leranth C, MacLusky NJ, Sakamoto H, Shanabrough M, Naftolin F: Glutamic acid decarboxylase-containing axons synapse on LHRH neurons in the rat medial preoptic area. Neuroendocrinology 1985;40:536-539.
    • (1985) Neuroendocrinology , vol.40 , pp. 536-539
    • Leranth, C.1    MacLusky, N.J.2    Sakamoto, H.3    Shanabrough, M.4    Naftolin, F.5
  • 59
    • 0002864868 scopus 로고
    • GABAA receptor subunit mRNAs in cells of the preoptic area: Colocalization with LHRH mRNA using dual-label in situ hybridization histochemistry
    • Petersen SL, McCrone S, Coy D, Adelman JP, Mahan LC: GABAA receptor subunit mRNAs in cells of the preoptic area: colocalization with LHRH mRNA using dual-label in situ hybridization histochemistry. Endocrinology J 1993;1:29-34.
    • (1993) Endocrinology J , vol.1 , pp. 29-34
    • Petersen, S.L.1    McCrone, S.2    Coy, D.3    Adelman, J.P.4    Mahan, L.C.5
  • 60
    • 4644225041 scopus 로고    scopus 로고
    • Dual-phenotype GABA/glutamate neurons in adult preoptic area: Sexual dimorphism and function
    • Ottem EN, Godwin JG, Krishnan S, Petersen SL: Dual-phenotype GABA/glutamate neurons in adult preoptic area: sexual dimorphism and function. J Neurosci 2004;24:8097-8105.
    • (2004) J Neurosci , vol.24 , pp. 8097-8105
    • Ottem, E.N.1    Godwin, J.G.2    Krishnan, S.3    Petersen, S.L.4
  • 61
    • 34548569387 scopus 로고    scopus 로고
    • Middle-aged female rats lack the dynamic changes in GAD(67) mRNA levels observed in young females on the day of a luteinising hormone surge
    • Grove-Strawser D, Jimenez-Linan M, Rubin BS: Middle-aged female rats lack the dynamic changes in GAD(67) mRNA levels observed in young females on the day of a luteinising hormone surge. J Neuroendocrinol 2007;19:708-716.
    • (2007) J Neuroendocrinol , vol.19 , pp. 708-716
    • Grove-Strawser, D.1    Jimenez-Linan, M.2    Rubin, B.S.3
  • 62
    • 0030862414 scopus 로고    scopus 로고
    • Transient effects of MK-801 administration on secretion of luteinizing hormone and prolactin in ovariectomized and estradiol-treated sheep
    • Jiang H, Haglof SA, Malven PV: Transient effects of MK-801 administration on secretion of luteinizing hormone and prolactin in ovariectomized and estradiol-treated sheep. Life Sci 1997;60:1447-1456.
    • (1997) Life Sci , vol.60 , pp. 1447-1456
    • Jiang, H.1    Haglof, S.A.2    Malven, P.V.3
  • 65
    • 33645230428 scopus 로고    scopus 로고
    • Neuroendocrine control of reproductive aging: Roles of GnRH neurons
    • Yin W, Gore AC: Neuroendocrine control of reproductive aging: roles of GnRH neurons. Reproduction 2006;131:403-414.
    • (2006) Reproduction , vol.131 , pp. 403-414
    • Yin, W.1    Gore, A.C.2
  • 66
    • 0032437602 scopus 로고    scopus 로고
    • Excitatory amino acids act on the median eminence nerve terminals to induce gonadotropin-releasing hormone release in female rats
    • Kawakami S, Ichikawa M, Murahashi K, Hirunagi K, Tsukamura H, Maeda K: Excitatory amino acids act on the median eminence nerve terminals to induce gonadotropin-releasing hormone release in female rats. Gen Comp Endocrinol 1998;112:372-382.
    • (1998) Gen Comp Endocrinol , vol.112 , pp. 372-382
    • Kawakami, S.1    Ichikawa, M.2    Murahashi, K.3    Hirunagi, K.4    Tsukamura, H.5    Maeda, K.6
  • 68
    • 0027387010 scopus 로고
    • N-Methyl-D,L-aspartic acid differentially affects LH release and LHRH mRNA levels in estrogen-treated ovariectomized control and androgen-sterilized rats
    • Liaw JJ, Barraclough CA: N-Methyl-D,L-aspartic acid differentially affects LH release and LHRH mRNA levels in estrogen-treated ovariectomized control and androgen-sterilized rats. Brain Res Mol Brain Res 1993;17:112-118.
    • (1993) Brain Res Mol Brain Res , vol.17 , pp. 112-118
    • Liaw, J.J.1    Barraclough, C.A.2
  • 69
    • 0036892797 scopus 로고    scopus 로고
    • Glutamatergic signaling through the N-methyl-D-aspartate receptor directly activates medial subpopulations of luteinizing hormone-releasing hormone (LHRH) neurons, but does not appear to mediate the effects of estradiol on LHRH gene expression
    • Ottem EN, Godwin JG, Petersen SL: Glutamatergic signaling through the N-methyl-D-aspartate receptor directly activates medial subpopulations of luteinizing hormone-releasing hormone (LHRH) neurons, but does not appear to mediate the effects of estradiol on LHRH gene expression. Endocrinology 2002;143:4837-4845.
    • (2002) Endocrinology , vol.143 , pp. 4837-4845
    • Ottem, E.N.1    Godwin, J.G.2    Petersen, S.L.3
  • 70
    • 0027440614 scopus 로고
    • NMDA receptor antagonist decreases the progesterone-induced increase in GnRH gene expression in the rat hypothalamus
    • Seong JY, Lee YK, Lee CC, Kim K: NMDA receptor antagonist decreases the progesterone-induced increase in GnRH gene expression in the rat hypothalamus. Neuroendocrinology 1993;58:234-239.
    • (1993) Neuroendocrinology , vol.58 , pp. 234-239
    • Seong, J.Y.1    Lee, Y.K.2    Lee, C.C.3    Kim, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.