Effects of aging on N-methyl-D-aspartate (NMDA)-induced GnRH and LH release in female rats

Brain Research

Volumn 740, Issue 1-2, 1996, Pages 234-238

  Arias, Pablo ^a   Carbone, Silvia ^a   Szwarcfarb, Berta ^a   Feleder, Carlos ^a   Rodríguez, Manuel ^a   Scacchi, Pablo ^a   Moguilevsky, Jaime A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

aging; excitatory amino acid; gonadotropin; gonadotropin releasing hormone; N methyl D aspartate

Indexed keywords

GONADORELIN; LUTEINIZING HORMONE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HORMONE RELEASE; HYPOTHALAMUS; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; LUTEINIZING HORMONE; N-METHYLASPARTATE; RATS; RATS, WISTAR;

EID: 0030592747     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)00862-1     Document Type: Article

References (32)

1. [1] Brann, D.W. and Mahesh, V.B., Endogenous excitatory amino acid involvement in the preovulatory and steroid-induced surge of gonadotropins in the female rat, Endocrinology, 128 (1991) 1541-1547.
2. [2] Brann, W.D. and Mahesh, V.B., Excitatory amino acids: function and significance in reproduction and neuroendocrine regulation, Front. Neuroendocrinol., 15 (1994) 3-49.
3. [3] Bourguignon, J.P., Geraud, A. and Franchimont P., Direct activation of gonadotropin releasing hormone secretion through a different receptors to neuroexcitatory amino acid, Neuroendocrinology, 49 (1982) 402-408.
4. [4] Carbone, S., Szwarcfarb, B., Otero Losada, M.E. and Moguilevsky, J.A., Effects of ovarian steroids on the gonadotropins response to N-methyl-D-aspartate and on the hypothalamic excitatory amino acids levels during sexual maturation in female rats, Endocrinology, 130 (1992) 1365-1370.
5. [5] Clemens, J.S. and Meites, J., Neuroendocrine status of old constant estrous rats, Neuroendocrinology, 7 (1971) 249-256.
6. [6] Cooper, R.I., Conn, P.M. and Walker, R.F., Characterization of the LH surge in middle-aged rats, Biol. Reprod., 23 (1980) 611-615.
7. [7] Finch, C.E., Catecholamine metabolism in the brains of aging male mice, Brain Res., 52 (1973) 271-276.
8. [8] Finch, C.E., Felicio, L.S., Mobbs, C.V. and Nelson, J.F., Ovarian and steroidal influences on neuroendocrine aging processes in female rodents, Endocrinol. Rev., 5 (1984) 467-497.
9. [9] Huang, H.H. and Meites, J., Reproductive capacity of aging female rats, Neuroendocrinolology, 17 (1975) 289-295.
10. [10] Huang, H.H., Steger, R.W., Bruni, J.F. and Meites, J. Patterns of sex steroid and gonadotropin secretion in aging female rats, Endocrinology, 103 (1978) 1855-1859.
11. [11] Hwang, C., Pu, H.F., Hwang, C.Y., Liu, J.Y., Yao, H.C., Tung, Y.F. and Wang, P.S., Age-related differences in the release of luteinizing hormone and gonadotropin-releasing hormone in ovariectomized rats, Neuroendocrinology, 52 (1990) 127-132.
12. [12] Jarry, H., Hirsch, B., Leonhardt, S. and Wuttke, W., Amino acid neurotransmitter release in the preoptic area of rats during the positive feedback actions of estradiol on LH release, Neuroendocrinology, 56 (1992) 133-140.
13. [13] Jarry, H., Perschl., A. and Wuttke, W., Further evidence that preoptic anterior hypothalamic GABAergic neurons are part of the GnRH pulse and surge generator, Acta Endocrinol. (Copenh.), 123 (1988) 573-579.
14. [14] Jinag, M.J. and Peng, M.T., Cytoplasmatic and nuclear binding of estradiol in the brain and pituitary of old female rats, Gerontology, 27 (1981) 51-57.
15. [15] López, F.J., Donoso, A.O. and Negro-Vilar, A., Endogenous excitatory amino acid neurotransmission regulates the estradiol-induced LH surge in ovariectomized rats, Endocrinology, 126 (1990) 1771-1773.
16. [16] Magnusqon, K.R. and Cotman, C.W., Age-related changes in excitatory amino acid receptors in two mouse strains, Neurobiol. Aging, 14 (1993) 197-206.
17. [17] Matt, D.W., Sayles, T.E., Jih, M.H., Kauma, S.W. and Lu, J.K.H., Alterations in the postovariectomy increases in in gonadotropin secretion in middle-aged persistent-estrous rats: correlation with pituitary gonadotropin subunit gene expression, Neuroendocrinology, 57 (1993) 351-358.
18. [18] Moguilevsky, J.A., Arias, P., Szwarcfarb, B., Carbone, S. and Rondina, D., Sexual maturation modifies the catecholaminergic control of gonadotropin secretion and the effect of ovarian hormones on hypothalamic neurotransmitters in female rats, Neuroendocrinology, 52 (1990) 393-398.
19. [19] Moguilevsky, J.A., Carbone, S., Szwarcfarb, B. and Rondina, D., Sexual maturation modifies the GABAergic control of gonadotropin secretion in female rats, Brain Rese., 563 (1991) 12-16.
20. [20] Ondo, J.G., Wheeler, D.D. and Dom, R.M. Hypothalamic site of action for N-methyl-D-aspartate (NMDA) on LH secretion, Life Sci., 43 (1988) 2283-2286.
21. [21] Pellegrino, L.T., Pellegrino, A.S. and Cushman, A.J., A Stereotaxic Atlas of the Rat Brain, Plenum Press, New York, 1967.
22. [22] Rogers, J. and Bloom, F.E., Neurotransmitters, metabolism and function in the aging central nervous system. In C.E. Finch and E.L. Schneider (Eds.), Handbook of the Biology of Aging, 2nd edn., Van Nostrand, New York, 1985, pp. 645-691.
23. [23] Romero, M.T., Silverman, A.J., Wise, P.M. and Witkin, W., Ultrastructural changes in gonadotropin-releasing hormone neurons as a function of age and ovariectomy in rats, Neuroscience, 58 (1994) 217-225.
24. [24] Rubin, B.S., Fox, T.O. and Bridges, R.S., Estrogen binding in nuclear and cytosolic extracts from brain and pituitary of middle age female rats, Brain Res., 383 (1986) 60-67.
25. [25] Serra, M., Ghiani, C.A., Fodd,i M.C., Motzo, C. and Biggio, G., NMDA receptor function is enhanced in the hippocampus of aged rats, Neurochem. Res., 19 (1994) 483-487.
26. [26] Shaar, C.J., Fuker, J.S., Riegle, G.D. and Meites, J., Effects of castration on gonadal steroids, on serum luteinizing hormone and prolactin in old and young rats, J. Endocrinol., 66 (1975) 45-51.
27. [27] Smith, W.A., Cooper, R.L. and Conn, P.M., Altered pituitary responsiveness to gonadotropin releasing hormone in middle-age rats with 4-day estrous cycle, Endocrinology, 111 (1982) 1843-1848.
28. [28] Simpkins, J.W., Mueller, G.P., Huang, H.H. and Meites, J., Evidence for depressed catecholamine and enhanced serotonin metabolism in aging male rats: possible relation to gonadotropin secretion, Endocrinology, 100 (1977) 1672-1678.
29. [29] Tukey, J.W., Comparing individual means in the analysis of variance, Biometrics, 5 (1949) 99-114.
30. [30] Whishaw, I.Q., Cio, J.D.D., Previsich, N. and Kolb, B., The variability of the interaural line vs the stability of bregma in rat stereotaxic surgery, Physiol. Behav., 19 (1977) 719-722.
31. [31] Wise, P.M., Alterations in proestrous LH, FSH and prolactin surges in middle-aged rats, Proc. Soc. Exp. Biol. Med., 169 (1982) 348-354.
32. [32] Wise, P.M., Estradiol-induced daily luteinizing hormone and prolactin surges in young and middle-aged rats: correlations with age-related changes in pituitary responsiveness and catecholamine turnover rates in microdissected brain areas, Endocrinology, 115 (1984) 801-809.