메뉴 건너뛰기




Volumn 22, Issue 4, 2008, Pages 267-277

Protease inhibitor resistance update: Where are we now?

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR PHOSPHATE; ATAZANAVIR; DARUNAVIR; INDINAVIR; LOPINAVIR; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; TIPRANAVIR;

EID: 42449133243     PISSN: 10872914     EISSN: None     Source Type: Journal    
DOI: 10.1089/apc.2007.0099     Document Type: Review
Times cited : (21)

References (71)
  • 1
    • 23744500093 scopus 로고    scopus 로고
    • Depletion of latent HIV-1 infection in vivo: A proof-of-concept study
    • Lehrman G, Hogue IB, Palmer S, et al. Depletion of latent HIV-1 infection in vivo: A proof-of-concept study. Lancet 2005;366:549-555.
    • (2005) Lancet , vol.366 , pp. 549-555
    • Lehrman, G.1    Hogue, I.B.2    Palmer, S.3
  • 2
    • 33747122666 scopus 로고    scopus 로고
    • Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel
    • Hammer SM, Saag MS, Schechter M, et al. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel. JAMA 2006;296:827-843.
    • (2006) JAMA , vol.296 , pp. 827-843
    • Hammer, S.M.1    Saag, M.S.2    Schechter, M.3
  • 3
    • 33750454570 scopus 로고    scopus 로고
    • Panel on Clinical Practices for the Treatment of HIV Infection, October 10, update. Available at:, Last accessed March 28, 2007
    • Panel on Clinical Practices for the Treatment of HIV Infection. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. U S Department of Health and Human Services October 10, 2006 update. Available at: http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL. pdf (Last accessed March 28, 2007).
    • (2006) Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents
  • 4
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998;338:853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr, F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 5
    • 0035800026 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease
    • Murphy EL, Collier AC, Kalish LA, et al. Highly active antiretroviral therapy decreases mortality and morbidity in patients with advanced HIV disease. Ann Intern Med 2001;135:17-26.
    • (2001) Ann Intern Med , vol.135 , pp. 17-26
    • Murphy, E.L.1    Collier, A.C.2    Kalish, L.A.3
  • 6
    • 0001102709 scopus 로고    scopus 로고
    • Altered natural history of AIDS-related opportunistic infections in the era of potent combination antiretroviral therapy
    • Jacobson MA, French M. Altered natural history of AIDS-related opportunistic infections in the era of potent combination antiretroviral therapy. AIDS 1998;12(suppl A):S157-S163.
    • (1998) AIDS , vol.12 , Issue.SUPPL. A
    • Jacobson, M.A.1    French, M.2
  • 7
    • 1442355578 scopus 로고    scopus 로고
    • HIV drug resistance
    • Clavel F, Hance AJ. HIV drug resistance. N Engl J Med 2004;350:1023-1035.
    • (2004) N Engl J Med , vol.350 , pp. 1023-1035
    • Clavel, F.1    Hance, A.J.2
  • 8
    • 3242877615 scopus 로고    scopus 로고
    • Resistance to HIV protease inhibitors: Mechanisms and clinical consequences
    • De Mendoza C, Soriano V. Resistance to HIV protease inhibitors: Mechanisms and clinical consequences. Curr Drug Metab 2004;5:321-328.
    • (2004) Curr Drug Metab , vol.5 , pp. 321-328
    • De Mendoza, C.1    Soriano, V.2
  • 9
    • 0035864943 scopus 로고    scopus 로고
    • Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
    • Deeks SG, Wrin T, Liegler T, et al. Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. N Engl J Med 2001;344:472-480.
    • (2001) N Engl J Med , vol.344 , pp. 472-480
    • Deeks, S.G.1    Wrin, T.2    Liegler, T.3
  • 10
    • 2142712566 scopus 로고    scopus 로고
    • Cross-resistance patterns among HIV protease inhibitors
    • Kozal M. Cross-resistance patterns among HIV protease inhibitors. AIDS Patient Care STDs 2004;18:199-208.
    • (2004) AIDS Patient Care STDs , vol.18 , pp. 199-208
    • Kozal, M.1
  • 11
    • 0038543353 scopus 로고    scopus 로고
    • Distinct cross-resistance profiles of the new protease inhibitors amprenavir, lopinavir, and atazanavir in a panel of clinical samples
    • Schnell T, Schmidt B, Moschik G, et al. Distinct cross-resistance profiles of the new protease inhibitors amprenavir, lopinavir, and atazanavir in a panel of clinical samples. AIDS 2003;17:1258-1261.
    • (2003) AIDS , vol.17 , pp. 1258-1261
    • Schnell, T.1    Schmidt, B.2    Moschik, G.3
  • 12
    • 3042855671 scopus 로고    scopus 로고
    • The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients
    • Turner D, Schapiro JM, Brenner BG, Wainberg MA. The influence of protease inhibitor resistance profiles on selection of HIV therapy in treatment-naive patients. Antivir Ther 2004;9:301-314.
    • (2004) Antivir Ther , vol.9 , pp. 301-314
    • Turner, D.1    Schapiro, J.M.2    Brenner, B.G.3    Wainberg, M.A.4
  • 13
    • 39049182918 scopus 로고    scopus 로고
    • The experts speak: New issues in the challenge of HIV drug resistance. Interview by Vicki Glaser
    • Baxter JD. The experts speak: New issues in the challenge of HIV drug resistance. Interview by Vicki Glaser. AIDS Patient Care STDs 2006;20:737-740.
    • (2006) AIDS Patient Care STDs , vol.20 , pp. 737-740
    • Baxter, J.D.1
  • 14
    • 33845433230 scopus 로고    scopus 로고
    • Successful treatment with atazanavir and lopinavir/ ritonavir combination therapy in protease inhibitor-susceptible and protease inhibitor-resistant HIV-infected patients
    • Gilliam BL, Chan-Tack KM, Qaqish RB, et al. Successful treatment with atazanavir and lopinavir/ ritonavir combination therapy in protease inhibitor-susceptible and protease inhibitor-resistant HIV-infected patients. AIDS Patient Care STDs 2006;20:745-759.
    • (2006) AIDS Patient Care STDs , vol.20 , pp. 745-759
    • Gilliam, B.L.1    Chan-Tack, K.M.2    Qaqish, R.B.3
  • 15
    • 3843151487 scopus 로고    scopus 로고
    • SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients
    • Gathe JC Jr, Ive P, Wood R, et al. SOLO: 48-week efficacy and safety comparison of once-daily fosamprenavir/ ritonavir versus twice-daily nelfinavir in naive HIV-1-infected patients. AIDS 2004;18:1529-1537.
    • (2004) AIDS , vol.18 , pp. 1529-1537
    • Gathe Jr, J.C.1    Ive, P.2    Wood, R.3
  • 16
    • 9144271024 scopus 로고    scopus 로고
    • Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine
    • Kempf DJ, King MS, Bernstein B, et al. Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine. J Infect Dis 2004;189:51-60.
    • (2004) J Infect Dis , vol.189 , pp. 51-60
    • Kempf, D.J.1    King, M.S.2    Bernstein, B.3
  • 17
    • 20444376886 scopus 로고    scopus 로고
    • Confronting the emergence of drug-resistant HIV type 1: Impact of antiretroviral therapy on individual and population resistance
    • Daar ES, Richman DD. Confronting the emergence of drug-resistant HIV type 1: Impact of antiretroviral therapy on individual and population resistance. AIDS Res Hum Retroviruses 2005;21:343-357.
    • (2005) AIDS Res Hum Retroviruses , vol.21 , pp. 343-357
    • Daar, E.S.1    Richman, D.D.2
  • 18
    • 0343183245 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adult HIV-1 infection: Recommendations of an International AIDS Society-USA Panel
    • Hirsch MS, Brun-Vézinet F, D'Aquila RT, et al. Antiretroviral drug resistance testing in adult HIV-1 infection: Recommendations of an International AIDS Society-USA Panel. JAMA 2000;283:2417-2426.
    • (2000) JAMA , vol.283 , pp. 2417-2426
    • Hirsch, M.S.1    Brun-Vézinet, F.2    D'Aquila, R.T.3
  • 19
    • 0037043652 scopus 로고    scopus 로고
    • Antiretroviral-drug resistance among patients recently infected with HIV
    • Little SJ, Holte S, Routy J-P, et al. Antiretroviral-drug resistance among patients recently infected with HIV. N Engl J Med 2002;347:385-394.
    • (2002) N Engl J Med , vol.347 , pp. 385-394
    • Little, S.J.1    Holte, S.2    Routy, J.-P.3
  • 20
    • 7244234570 scopus 로고    scopus 로고
    • Current patterns in the epidemiology of primary HIV drug resistance in North America and Europe
    • Pillay D. Current patterns in the epidemiology of primary HIV drug resistance in North America and Europe. Antivir Ther 2004;9:695-702.
    • (2004) Antivir Ther , vol.9 , pp. 695-702
    • Pillay, D.1
  • 21
    • 0347995130 scopus 로고    scopus 로고
    • Treatment of antiretroviral-drug-resistant HIV-1 infection
    • Deeks SG. Treatment of antiretroviral-drug-resistant HIV-1 infection. Lancet 2003;362:2002-2011.
    • (2003) Lancet , vol.362 , pp. 2002-2011
    • Deeks, S.G.1
  • 22
    • 17144369901 scopus 로고    scopus 로고
    • Long term probability of detection of HIV-1 drug resistance after starting antiretroviral therapy in routine clinical practice
    • Phillips AN, Dunn D, Sabin C, et al. Long term probability of detection of HIV-1 drug resistance after starting antiretroviral therapy in routine clinical practice. AIDS 2005;19:487-494.
    • (2005) AIDS , vol.19 , pp. 487-494
    • Phillips, A.N.1    Dunn, D.2    Sabin, C.3
  • 23
    • 13444279867 scopus 로고    scopus 로고
    • Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: Implications for routine resistance screening before initiation of antiretroviral therapy
    • Novak RM, Chen L, MacArthur RD, et al. Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: Implications for routine resistance screening before initiation of antiretroviral therapy. Clin Infect Dis 2005;40:468-474.
    • (2005) Clin Infect Dis , vol.40 , pp. 468-474
    • Novak, R.M.1    Chen, L.2    MacArthur, R.D.3
  • 24
    • 33750630109 scopus 로고    scopus 로고
    • Update of the Drug Resistance Mutations in HIV-1: Fall 2006
    • Johnson VA, Brun-Vézinet F, Clotet B, et al. Update of the Drug Resistance Mutations in HIV-1: Fall 2006. Top HIV Med 2006;14:125-130.
    • (2006) Top HIV Med , vol.14 , pp. 125-130
    • Johnson, V.A.1    Brun-Vézinet, F.2    Clotet, B.3
  • 25
    • 3342913702 scopus 로고    scopus 로고
    • Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing
    • Rhee SY, Liu T, Ravela J, Gonzales MJ, Shafer RW. Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing. Antimicrob Agents Chemother 2004;48:3122-3126.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3122-3126
    • Rhee, S.Y.1    Liu, T.2    Ravela, J.3    Gonzales, M.J.4    Shafer, R.W.5
  • 26
    • 22544486548 scopus 로고    scopus 로고
    • HIV-1 protease and reverse-transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance
    • Rhee SY, Fessel WJ, Zolopa AR, et al. HIV-1 protease and reverse-transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis 2005;192:456-465.
    • (2005) J Infect Dis , vol.192 , pp. 456-465
    • Rhee, S.Y.1    Fessel, W.J.2    Zolopa, A.R.3
  • 27
    • 20944431808 scopus 로고    scopus 로고
    • Novel human immunodeficiency virus type 1 protease mutations potentially involved in resistance to protease inhibitors
    • Svicher V, Ceccherini-Silberstein F, Erba F, et al. Novel human immunodeficiency virus type 1 protease mutations potentially involved in resistance to protease inhibitors. Antimicrob Agents Chemother 2005;49:2015-2025.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2015-2025
    • Svicher, V.1    Ceccherini-Silberstein, F.2    Erba, F.3
  • 28
    • 0037310296 scopus 로고    scopus 로고
    • Selection of high-level resistance to human immunodeficiency virus type 1 protease inhibitors
    • Watkins T, Resch W, Irlbeck D, Swanstrom R. Selection of high-level resistance to human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother 2003;47:759-769.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 759-769
    • Watkins, T.1    Resch, W.2    Irlbeck, D.3    Swanstrom, R.4
  • 29
    • 21444441862 scopus 로고    scopus 로고
    • Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: Clinical impact and molecular mechanisms
    • Winters MA, Merigan TC. Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: Clinical impact and molecular mechanisms. Antimicrob Agents Chemother 2005;49:2575-2582.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2575-2582
    • Winters, M.A.1    Merigan, T.C.2
  • 30
    • 0031724008 scopus 로고    scopus 로고
    • Resistance to human immunodeficiency virus type 1 protease inhibitors
    • Boden D, Markowitz M. Resistance to human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother 1998;42:2775-2783.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2775-2783
    • Boden, D.1    Markowitz, M.2
  • 31
    • 0037155193 scopus 로고    scopus 로고
    • Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors
    • Gatanaga H, Suzuki Y, Tsang H, et al. Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease inhibitors. J Biol Chem 2002;277:5952-5961.
    • (2002) J Biol Chem , vol.277 , pp. 5952-5961
    • Gatanaga, H.1    Suzuki, Y.2    Tsang, H.3
  • 32
    • 0033863985 scopus 로고    scopus 로고
    • Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: Virus fitness in the absence and in the presence of drug
    • Mammano F, Trouplin V, Zennou V, Clavel F. Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: Virus fitness in the absence and in the presence of drug. J Virol 2000;74:8524-8531.
    • (2000) J Virol , vol.74 , pp. 8524-8531
    • Mammano, F.1    Trouplin, V.2    Zennou, V.3    Clavel, F.4
  • 33
    • 0942290560 scopus 로고    scopus 로고
    • Gag non-cleavage site mutations contribute to full recovery of viral fitness in protease inhibitor-resistant human immunodeficiency virus type 1
    • Myint L, Matsuda M, Matsuda Z, et al. Gag non-cleavage site mutations contribute to full recovery of viral fitness in protease inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother 2004;48:444-452.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 444-452
    • Myint, L.1    Matsuda, M.2    Matsuda, Z.3
  • 34
    • 6344249119 scopus 로고    scopus 로고
    • Amino acid insertions near Gag cleavage sites restore the otherwise compromised replication of human immunodeficiency virus type 1 variants resistant to protease inhibitors
    • Tamiya S, Mardy S, Kavlick MF, Yoshimura K, Mistuya H. Amino acid insertions near Gag cleavage sites restore the otherwise compromised replication of human immunodeficiency virus type 1 variants resistant to protease inhibitors. J Virol 2004;78:12030-12040.
    • (2004) J Virol , vol.78 , pp. 12030-12040
    • Tamiya, S.1    Mardy, S.2    Kavlick, M.F.3    Yoshimura, K.4    Mistuya, H.5
  • 35
    • 10044291352 scopus 로고    scopus 로고
    • Novel HIV drug resistance mechanism leading to protease inhibitor (PI) resistance in response to a high genetic barrier PI in vitro [abstract 36]
    • Nijhuis M, van Maarseveen NM, Schipper P, et al. Novel HIV drug resistance mechanism leading to protease inhibitor (PI) resistance in response to a high genetic barrier PI in vitro [abstract 36]. Antivir Ther 2004;9:S42.
    • (2004) Antivir Ther , vol.9
    • Nijhuis, M.1    van Maarseveen, N.M.2    Schipper, P.3
  • 36
    • 0035289690 scopus 로고    scopus 로고
    • International perspectives on antiretroviral resistance: Resistance to protease inhibitors
    • Miller V. International perspectives on antiretroviral resistance: Resistance to protease inhibitors. J Acquir Immune Defic Syndr 2001;26(suppl 1):S34-S50.
    • (2001) J Acquir Immune Defic Syndr , vol.26 , Issue.SUPPL. 1
    • Miller, V.1
  • 37
    • 14744283486 scopus 로고    scopus 로고
    • Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: Mutation patterns and baseline correlates
    • Mo H, King MS, King K, et al. Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir- and ritonavir-based therapy: Mutation patterns and baseline correlates. J Virol 2005;79:3329-3338.
    • (2005) J Virol , vol.79 , pp. 3329-3338
    • Mo, H.1    King, M.S.2    King, K.3
  • 38
    • 0037379517 scopus 로고    scopus 로고
    • Activities of atazanavir (BMS-232632) against a large panel of human immunodeficiency virus type 1 clinical isolates resistant to one or more approved protease inhibitors
    • Colonno RJ, Thiry A, Limoli K, Parkin N. Activities of atazanavir (BMS-232632) against a large panel of human immunodeficiency virus type 1 clinical isolates resistant to one or more approved protease inhibitors. Antimicrob Agents Chemother 2003;47:1324-1333.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1324-1333
    • Colonno, R.J.1    Thiry, A.2    Limoli, K.3    Parkin, N.4
  • 39
    • 0034909925 scopus 로고    scopus 로고
    • Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
    • Kempf DJ, Isaacson JD, King MS, et al. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J Virol 2001;75:7462-7469.
    • (2001) J Virol , vol.75 , pp. 7462-7469
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3
  • 40
    • 21744450290 scopus 로고    scopus 로고
    • Diverse pattern of protease inhibitor resistance mutations in HIV-1 infected patients failing nelfinavir
    • Svedhem V, Lindkvist A, Bergroth T, Knut L, Sonnerborg A. Diverse pattern of protease inhibitor resistance mutations in HIV-1 infected patients failing nelfinavir. J Med Virol 2005;76:447-451.
    • (2005) J Med Virol , vol.76 , pp. 447-451
    • Svedhem, V.1    Lindkvist, A.2    Bergroth, T.3    Knut, L.4    Sonnerborg, A.5
  • 41
    • 4644305654 scopus 로고    scopus 로고
    • Fosamprenavir: A review of its use in the management of antiretroviral therapy-naive patients with HIV infection
    • Chapman TM, Plosker GL, Perry CM. Fosamprenavir: A review of its use in the management of antiretroviral therapy-naive patients with HIV infection. Drugs 2004;64:2101-2124.
    • (2004) Drugs , vol.64 , pp. 2101-2124
    • Chapman, T.M.1    Plosker, G.L.2    Perry, C.M.3
  • 42
    • 0347990584 scopus 로고    scopus 로고
    • The NEAT study: A 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patients
    • Rodriguez-French A, Boghossian J, Gray GE, et al. The NEAT study: A 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patients. J Acquir Immune Defic Syndr 2004;35:22-32.
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 22-32
    • Rodriguez-French, A.1    Boghossian, J.2    Gray, G.E.3
  • 43
    • 0038555736 scopus 로고    scopus 로고
    • Improving lopinavir genotype algorithm through phenotype correlations: Novel mutation patterns and amprenavir cross-resistance
    • Parkin NT, Chappey C, Petropoulos CJ. Improving lopinavir genotype algorithm through phenotype correlations: Novel mutation patterns and amprenavir cross-resistance. AIDS 2003;17:955-961.
    • (2003) AIDS , vol.17 , pp. 955-961
    • Parkin, N.T.1    Chappey, C.2    Petropoulos, C.J.3
  • 44
    • 20944446492 scopus 로고    scopus 로고
    • Virological and pharmacological parameters predicting the response to lopinavir-ritonavir in heavily protease inhibitor-experienced patients
    • Marcelin AG, Cohen-Codar I, King MS, et al. Virological and pharmacological parameters predicting the response to lopinavir-ritonavir in heavily protease inhibitor-experienced patients. Antimicrob Agents Chemother 2005;49:1720-1726.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1720-1726
    • Marcelin, A.G.1    Cohen-Codar, I.2    King, M.S.3
  • 45
    • 0141550178 scopus 로고    scopus 로고
    • Emergence of a novel lopinavir resistance mutation at codon 47 correlates with ARV utilization
    • Kagan RM, Shenderovich MD, Ramnarayan K, et al. Emergence of a novel lopinavir resistance mutation at codon 47 correlates with ARV utilization. Antivir Ther 2003;8:S54.
    • (2003) Antivir Ther , vol.8
    • Kagan, R.M.1    Shenderovich, M.D.2    Ramnarayan, K.3
  • 46
    • 4344631471 scopus 로고    scopus 로고
    • Isolated lopinavir resistance after virological rebound of a lopinavir/ritonavir-based regimen
    • Parkin NT, Petropoulos CJ, Chappey C, et al. Isolated lopinavir resistance after virological rebound of a lopinavir/ritonavir-based regimen. Antivir Ther 2004;9:S79.
    • (2004) Antivir Ther , vol.9
    • Parkin, N.T.1    Petropoulos, C.J.2    Chappey, C.3
  • 47
    • 9644268882 scopus 로고    scopus 로고
    • Atazanavir for the treatment of human immunodeficiency virus infection
    • Busti AJ, Hall RG II, Margolis DM. Atazanavir for the treatment of human immunodeficiency virus infection. Pharmacotherapy 2004;24:1732-1747.
    • (2004) Pharmacotherapy , vol.24 , pp. 1732-1747
    • Busti, A.J.1    Hall II, R.G.2    Margolis, D.M.3
  • 48
    • 2442657656 scopus 로고    scopus 로고
    • Identification of I50L as the signature atazanavir (ATV)-resistance mutation in treatment-naive HIV-1-infected patients receiving ATV-containing regimens
    • Colonno R, Rose R, McLaren C, et al. Identification of I50L as the signature atazanavir (ATV)-resistance mutation in treatment-naive HIV-1-infected patients receiving ATV-containing regimens. J Infect Dis 2004;189:1802-1810.
    • (2004) J Infect Dis , vol.189 , pp. 1802-1810
    • Colonno, R.1    Rose, R.2    McLaren, C.3
  • 49
    • 42449110511 scopus 로고    scopus 로고
    • Colonno R, Parkin N, McLaren C, et al. Pathways to atazanavir resistance in treatment-experienced patients and impact of residue 50 substitutions [abstract 656]. In: Program and Abstracts of the 11th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA: February 8-11, 2004.
    • Colonno R, Parkin N, McLaren C, et al. Pathways to atazanavir resistance in treatment-experienced patients and impact of residue 50 substitutions [abstract 656]. In: Program and Abstracts of the 11th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA: February 8-11, 2004.
  • 50
    • 42449117763 scopus 로고    scopus 로고
    • Coakley E, Mass M, Parkin N. Atazanavir resistance in a protease inhibitor-naïve patient treated with atazanavir/ritonavir associated with development of high-level atazanavir resistance and the N88S mutation in protease [abstract 716]. In: Program and Abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 22-25, 2005.
    • Coakley E, Mass M, Parkin N. Atazanavir resistance in a protease inhibitor-naïve patient treated with atazanavir/ritonavir associated with development of high-level atazanavir resistance and the N88S mutation in protease [abstract 716]. In: Program and Abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 22-25, 2005.
  • 51
    • 33750338185 scopus 로고    scopus 로고
    • Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir
    • Baxter JD, Schapiro JM, Boucher CA, et al. Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol 2006;80:10794-10801.
    • (2006) J Virol , vol.80 , pp. 10794-10801
    • Baxter, J.D.1    Schapiro, J.M.2    Boucher, C.A.3
  • 52
    • 23744461868 scopus 로고    scopus 로고
    • Tipranavir: A ritonavir-boosted protease inhibitor
    • Croom KF, Keam SJ. Tipranavir: A ritonavir-boosted protease inhibitor. Drugs 2005;65:1669-1677.
    • (2005) Drugs , vol.65 , pp. 1669-1677
    • Croom, K.F.1    Keam, S.J.2
  • 53
    • 33746576313 scopus 로고    scopus 로고
    • Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials
    • Hicks CB, Cahn P, Cooper DA, et al. Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials. Lancet 2006;368:466-475.
    • (2006) Lancet , vol.368 , pp. 466-475
    • Hicks, C.B.1    Cahn, P.2    Cooper, D.A.3
  • 54
    • 19544386471 scopus 로고    scopus 로고
    • TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
    • De Meyer S, Azijn H, Surleraux D, et al. TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother 2005;49:2314-2321.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 2314-2321
    • De Meyer, S.1    Azijn, H.2    Surleraux, D.3
  • 55
    • 33846018679 scopus 로고    scopus 로고
    • Phenotypic and genotypic determinants of resistance to TMC114: Pooled analysis of POWER 1, 2, and 3
    • De Meyer S, Vangeneugden T, Lefebvre E, et al. Phenotypic and genotypic determinants of resistance to TMC114: Pooled analysis of POWER 1, 2, and 3. Antivir Ther 2006;11:S83.
    • (2006) Antivir Ther , vol.11
    • De Meyer, S.1    Vangeneugden, T.2    Lefebvre, E.3
  • 56
    • 42449122436 scopus 로고    scopus 로고
    • Structural basis for the resistance profile of the HIV-1 protease inhibitor PL-100
    • Vacca JP, Holloway MK, Allison TJ, et al. Structural basis for the resistance profile of the HIV-1 protease inhibitor PL-100. Antivir Ther 2007;12:S17.
    • (2007) Antivir Ther , vol.12
    • Vacca, J.P.1    Holloway, M.K.2    Allison, T.J.3
  • 57
    • 42449118624 scopus 로고    scopus 로고
    • In vitro HIV-1 resistance selection to GS-8374, a novel phosphonate protease inhibitor: Comparison with lopinavir, atazanavir and darunavir
    • Callebaut C, Stray K, Tsai J, et al. In vitro HIV-1 resistance selection to GS-8374, a novel phosphonate protease inhibitor: Comparison with lopinavir, atazanavir and darunavir. Antivir Ther 2007;12:S18.
    • (2007) Antivir Ther , vol.12
    • Callebaut, C.1    Stray, K.2    Tsai, J.3
  • 58
    • 35548981980 scopus 로고    scopus 로고
    • Highly potent protease inhibitors with novel escape pathways
    • Afonina E, Gulnik SV, Eissenstat M, et al. Highly potent protease inhibitors with novel escape pathways. Antivir Ther 2007;12:S21.
    • (2007) Antivir Ther , vol.12
    • Afonina, E.1    Gulnik, S.V.2    Eissenstat, M.3
  • 59
    • 34250169806 scopus 로고    scopus 로고
    • A novel bis-tetrahydrofuranylurethane- containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro
    • Amano M, Koh Y, Das D, et al. A novel bis-tetrahydrofuranylurethane- containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother 2007;51:2143-2155.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2143-2155
    • Amano, M.1    Koh, Y.2    Das, D.3
  • 60
    • 0034102129 scopus 로고    scopus 로고
    • Frequency of antiretroviral drug resistance mutations in HIV-1 strains from patients failing triple drug regimens
    • Winters MA, Baxter JD, Mayers DL, et al. Frequency of antiretroviral drug resistance mutations in HIV-1 strains from patients failing triple drug regimens. Antivir Ther 2000;5:57-63.
    • (2000) Antivir Ther , vol.5 , pp. 57-63
    • Winters, M.A.1    Baxter, J.D.2    Mayers, D.L.3
  • 61
    • 0033921617 scopus 로고    scopus 로고
    • Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: A survey of over 6000 samples
    • Hertogs K, Bloor S, Kemp SD, et al. Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: A survey of over 6000 samples. AIDS 2000;14:1203-1210.
    • (2000) AIDS , vol.14 , pp. 1203-1210
    • Hertogs, K.1    Bloor, S.2    Kemp, S.D.3
  • 62
    • 0034002883 scopus 로고    scopus 로고
    • A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir
    • Ziermann R, Limoli K, Das K, et al. A mutation in human immunodeficiency virus type 1 protease, N88S, that causes in vitro hypersensitivity to amprenavir. J Virol 2000;74:4414-4419.
    • (2000) J Virol , vol.74 , pp. 4414-4419
    • Ziermann, R.1    Limoli, K.2    Das, K.3
  • 63
    • 42449121586 scopus 로고    scopus 로고
    • Schooley R, Haubrich R, Thompson M, et al. Effect of amprenavir hyper-susceptibility on the response to APV/ritonavir-based therapy in ART-experienced adults selected by baseline susceptibility (ESS40006): 24-week data [Abstract 143]. In: Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 10-14, 2003.
    • Schooley R, Haubrich R, Thompson M, et al. Effect of amprenavir hyper-susceptibility on the response to APV/ritonavir-based therapy in ART-experienced adults selected by baseline susceptibility (ESS40006): 24-week data [Abstract 143]. In: Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 10-14, 2003.
  • 64
    • 42449148507 scopus 로고    scopus 로고
    • Colonno R, Rose R, Cianci C, et al. Emergence of atazanavir resistance and maintenance of susceptibility to other PIs is associated with an I50L substitution in HIV protease [abstract 597]. In: Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 10-14, 2003.
    • Colonno R, Rose R, Cianci C, et al. Emergence of atazanavir resistance and maintenance of susceptibility to other PIs is associated with an I50L substitution in HIV protease [abstract 597]. In: Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 10-14, 2003.
  • 65
    • 42449084301 scopus 로고    scopus 로고
    • Menzo S, Monachetti A, Balotta C, et al. Fitness and drug-dependence in HIV-1 variants resistant to protease inhibitors [abstract 618]. In: Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 10-14, 2003.
    • Menzo S, Monachetti A, Balotta C, et al. Fitness and drug-dependence in HIV-1 variants resistant to protease inhibitors [abstract 618]. In: Program and Abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Boston, MA: February 10-14, 2003.
  • 66
    • 33745785644 scopus 로고    scopus 로고
    • Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patients
    • Kozal MJ, Huppler Hullsiek K, Leduc R, et al. Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patients. Antivir Ther 2006;11:457-463.
    • (2006) Antivir Ther , vol.11 , pp. 457-463
    • Kozal, M.J.1    Huppler Hullsiek, K.2    Leduc, R.3
  • 67
    • 9644281075 scopus 로고    scopus 로고
    • Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance
    • Johnston E, Winters MA, Rhee SY, et al. Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance. Antimicrob Agents Chemother 2004;48:4864-4868.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 4864-4868
    • Johnston, E.1    Winters, M.A.2    Rhee, S.Y.3
  • 68
    • 2642533777 scopus 로고    scopus 로고
    • Preventing and managing antiretroviral drug resistance
    • Kuritzkes DR. Preventing and managing antiretroviral drug resistance. AIDS Patient Care STDS 2004;18:259-273.
    • (2004) AIDS Patient Care STDS , vol.18 , pp. 259-273
    • Kuritzkes, D.R.1
  • 69
    • 33749036548 scopus 로고    scopus 로고
    • Disadvantages of structured treatment interruption persist in patients with multidrug-resistant HIV-1: Final results of the CPCRA 064 study
    • Lawrence J, Hullsiek KH, Thackeray LM, et al. Disadvantages of structured treatment interruption persist in patients with multidrug-resistant HIV-1: Final results of the CPCRA 064 study. J Acquir Immune Defic Syndr 2006;43:169-178.
    • (2006) J Acquir Immune Defic Syndr , vol.43 , pp. 169-178
    • Lawrence, J.1    Hullsiek, K.H.2    Thackeray, L.M.3
  • 70
    • 23044431640 scopus 로고    scopus 로고
    • Impact of drug resistance genotypes on CD4+ counts and plasma viremia in heavily antiretroviral- experienced HIV-infected patients
    • Rodes B, Garcia F, Gutierrez C, et al. Impact of drug resistance genotypes on CD4+ counts and plasma viremia in heavily antiretroviral- experienced HIV-infected patients. J Med Virol 2005;77:23-28.
    • (2005) J Med Virol , vol.77 , pp. 23-28
    • Rodes, B.1    Garcia, F.2    Gutierrez, C.3
  • 71
    • 33845943963 scopus 로고    scopus 로고
    • HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance
    • Shafer RW, Rhee SY, Pillay D, et al. HIV-1 protease and reverse transcriptase mutations for drug resistance surveillance. AIDS 2007;21:215-223.
    • (2007) AIDS , vol.21 , pp. 215-223
    • Shafer, R.W.1    Rhee, S.Y.2    Pillay, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.