In vivo long-term imaging and radioiodine therapy by sodium-iodide symporter gene expression using a lentiviral system containing ubiquitin C promoter

Cancer Biology and Therapy

Volumn 6, Issue 7, 2007, Pages 1130-1135

  Hyun, Joo Kim ^a   Yong, Hyun Jeon ^a   Joo, Hyun Kang ^b   Yong, Jin Lee ^a   Kwang, Il Kim ^a   Hye, Kyung Chung ^a   Jae, Min Jeong ^a   Dong, Soo Lee ^a   Myung, Chul Lee ^a   Chung, June Key ^a,c  

^a Seoul National University College of Medicine   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

CT26 colon carcinoma cell line; Lentiviral vector system; Scintigraphic image; Sodium iodide symporter (NIS); Ubiquitin C promoter; 99mTc pertechnetate

Indexed keywords

IODINE 131; LENTIVIRUS VECTOR; PERTECHNETIC ACID TC 99M; POTASSIUM PERCHLORATE; SODIUM IODIDE SYMPORTER; UBIQUITIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; IMAGING; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MONITORING; MOUSE; NONHUMAN; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; SCINTIGRAPHY; TUMOR CELL; TUMOR GROWTH; TUMOR VOLUME; VIRAL GENE DELIVERY SYSTEM;

EID: 42449129711     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.7.4342     Document Type: Article

References (33)

1. Vigna E, Naldini L. Lentiviral vectors: Excellent tools for experimental gene transfer and promising candidates for gene therapy. J Gene Med 2000; 2:308-16.
2. Lewis PF, Emerman M. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J Virol 1994; 68:510-6.
3. Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L, Trono D. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 1998; 72:9873-80.
4. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D. In vivo gene delivery and stable transduction of non-dividing cells by a lentiviral vector. Science 1996; 272:263-7.
5. Schorpp M, Jager R, Schellander K, Schenkel J, Wagner EF, Weiher H, Angel P. The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res 1996; 24:1787-8.
6. Baskar JF, Smith PP, Nilaver G, Jupp RA, Hoffmann S, Peffer NJ, Tenney DJ, Colberg-Poley AM, Ghazal P, Nelson JA. The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice. J Virol 1996; 70:3207-14.
7. Loser P, Jennings GS, Strauss M, Sandig V. Reactivation of the previously silenced cytomegalovirus major immediate-early promoter in the mouse liver: Involvement of NFkappaB. J Virol 1998; 72:180-90.
8. Kim YH, Lee DS, Kang JH, Lee YJ, Chung JK, Roh JK, Kim SU, Lee MC. Reversing the silencing of reporter sodium/iodide symporter transgene for stem cell tracking. J Nucl Med 2005; 46:305-11.
9. Rosenqvist N, Hard Af Segerstad C, Samuelsson C, Johansen J, Lundberg C. Activation of silenced transgene expression in neural precursor cell lines by inhibitors of histone deacetylation. J Gene Med 2002; 4:248-57.
10. Gill DR, Smyth SE, Goddard CA, Pringle IA, Higgins CF, Colledge WH, Hyde SC. Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter. Gene Ther 2001; 8:1539-46.
11. Shah K, Jacobs A, Breakefield XO, Weissleder R. Molecular imaging of gene therapy for cancer. Gene Ther 2004; 11:1175-87.
12. Follenzi A, Sabatino G, Lombardo A, Boccaccio C, Naldini L. Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum Gene Ther 2002; 13:243-60.
13. Chung JK. Sodium iodide symporter: Its role in nuclear medicine. J Nucl Med 2002; 43:1188-200.
14. Dwyer RM, Bergert ER, O'Connor MK, Gendler SJ, Morris JC. Sodium iodide symporter-mediated radioiodide imaging and therapy of ovarian tumor xenografts in mice. Gene Ther 2006; 13:60-6.
15. Cho JY, Shen DH, Yang W, Williams B, Buckwalter TL, La Perle KM, Hinkle G, Pozderac R, Kloos R, Nagaraja HN, Barth RF, Jhiang SM. In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas. Gene Ther 2002; 9:1139-45.
16. Allport JR, Weissleder R. In vivo imaging of gene and cell therapies. Exp Hematol 2001; 29:1237-46.
17. Dingli D, Russell SJ, Morris IIIrd JC. In vivo imaging and tumor therapy with the sodium iodide symporter. J Cell Biochem 2003; 90:1079-86.
18. Schipper ML, Weber A, Behe M, Goke R, Joba W, Schmidt H, Bert T, Simon B, Arnold R, Heufelder AE, Behr TM. Radioiodide treatment after sodium iodide symporter gene transfer is a highly effective therapy in neuroendocrine tumor cells. Cancer Res 2003; 63:1333-8.
19. Cho JA, Yeo DJ, Son HY, Kim HW, Jung DS, Ko JK, Koh JS, Kim YN, Kim CW. Exosomes: A new delivery system for tumor antigens in cancer immunotherapy. Int J Cancer 2005; 114:613-22.
20. Weiss SJ, Philp NJ, Grollman EF. Iodide transport in a continuous line of cultured cells from rat thyroid. Endocrinology 1984; 114:1090-8.
21. Iyer M, Salazar FB, Wu L, Carey M, Gambhir SS. Bioluminescence imaging of systemic tumor targeting using a prostate-specific lentiviral vector. Hum Gene Ther 2006; 17:125-32.
22. De A, Lewis XZ, Gambhir SS. Non-invasive imaging of lentiviral-mediated reporter gene expression in living mice. Mol Ther 2003; 7:681-91.
23. Lee WW, Moon DH, Park SY, Jin J, Kim SJ, Lee H. Imaging of adenovirus-mediated expression of human sodium iodide symporter gene by 99mTcO4 scintigraphy in mice. Nucl Med Biol 2004; 31:31-40.
24. Kang JH, Chung JK, Lee YJ, Shin JH, Jeong JM, Lee DS, Lee MC. Establishment of a human hepatocellular carcinoma cell line highly expressing sodium iodide symporter for radionuclide gene therapy. J Nucl Med 2004; 45:1571-6.
25. Lee YJ, Chung JK, Shin JH, Kang JH, Jeong JM, Lee DS, Lee MC. In vitro and in vivo properties of a human anaplastic thyroid carcinoma cell line transfected with the sodium iodide symporter gene. Thyroid 2004; 14:889-95.
26. Gerolami R, Uch R, Jordier F, Chapel S, Bagnis C, Brechot C, Mannoni P. Gene transfer to hepatocellular carcinoma: Transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors. Cancer Gene Ther 2000; 7:1286-92.
27. Grassi G, Maccaroni P, Meyer R, Kaiser H, D'Ambrosio E, Pascale E, Grassi M, Kuhn A, Di Nardo P, Kandolf R, Kupper JH. Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87. Carcinogenesis 2003; 24:1625-35.
28. Spitzweg C, O'Connor MK, Bergert ER, Tindall DJ, Young CY, Morris JC. Treatment of prostate cancer by radioiodine therapy after tissue-specific expression of the sodium iodide symporter. Cancer Res 2000; 60:6526-30.
29. Boland A, Ricard M, Opolon P, Bidart JM, Yeh P, Filetti S, Schlumberger M, Perricaudet M. Adenovirus-mediated transfer of the thyroid sodium/iodide symporter gene into tumors for a targeted radiotherapy. Cancer Res 2000; 60:3484-92.
30. Shimura H, Haraguchi K, Miyazaki A, Endo T, Onaya T. Iodide uptake and experimental 131I therapy in transplanted undifferentiated thyroid cancer cells expressing the Na+/ I- symporter gene. Endocrinology 1997; 138:4493-6.
31. Schipper ML, Riese CG, Seitz S, Weber A, Behe M, Schurrat T, Schramm N, Keil B, Alfke H, Behr TM. Efficacy of (99m)Tc pertechnetate and (131)I radioisotope therapy in sodium/iodide symporter (NIS)-expressing neuroendocrine tumors in vivo. Eur J Nucl Med Mol Imaging 2006.
32. Dadachova E, Bouzahzah B, Zuckier LS, Pestell RG. Rhenium-188 as an alternative to Iodine-131 for treatment of breast tumors expressing the sodium/iodide symporter (NIS). Nucl Med Biol 2002; 29:13-8.
33. Haberkorn U, Beuter P, Kubler W, Eskerski H, Eisenhut M, Kinscherf R, Zitzmann S, Strauss LG, Dimitrakopoulou-Strauss A, Altmann A. Iodide kinetics and dosimetry in vivo after transfer of the human sodium iodide symporter gene in rat thyroid carcinoma cells. J Nucl Med 2004; 45:827-33.