Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3β

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 13, 2008, Pages 5063-5068

  Mohanty, Subhasis ^a   Town, Terrence ^a,c   Yagi, Tomohito ^a,d   Scheidig, Christina ^a   Kwan, Kelvin Y ^b   Allore, Heather G ^a   Flavell, Richard A ^a   Shaw, Albert C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Cell cycle checkpoint; DNA repair; Radiation sensitivity

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE RAD3; DNA TOPOISOMERASE; DNA TOPOISOMERASE 3BETA; HISTONE H2AX; PROTEIN P53; SERINE; DNA TOPOISOMERASE III; H2AX PROTEIN, MOUSE; HISTONE; MUTAGENIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA REPLICATION FORK; DNA STRAND BREAKAGE; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; ULTRAVIOLET RADIATION; ANIMAL; CELL LINE; CELL PROLIFERATION; DRUG EFFECT; GENETICS; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION;

ATAXIA TELANGIECTASIA; MAMMALIA; MURINAE;

ANIMALS; CELL LINE; CELL PROLIFERATION; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; HISTONES; MICE; MICE, KNOCKOUT; MUTAGENS; PHOSPHORYLATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 42449099885     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801235105     Document Type: Article

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