메뉴 건너뛰기




Volumn 3, Issue 2, 2008, Pages 81-85

Rationale for targeted therapies in hepatocellular carcinoma

Author keywords

Angiogenesis; EGFR; IGF 1R; MTOR; Rapamycin; Tyrosine kinase inhibitors

Indexed keywords


EID: 42449088069     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-008-0079-4     Document Type: Article
Times cited : (1)

References (26)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterol 132:2557-2576
    • (2007) Gastroenterol , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 34548720158 scopus 로고    scopus 로고
    • Randomized phase III trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma
    • 18S
    • Llovet J, Ricci S, Mazzaferro V et al (2007) Randomized phase III trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma. J Clin Oncol (2007 ASCO Annual Meeting Proceedings) 25(18S):LBA1
    • (2007) J Clin Oncol (2007 ASCO Annual Meeting Proceedings) , vol.25 , pp. 1
    • Llovet, J.1    Ricci, S.2    Mazzaferro, V.3
  • 3
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-alfa JK, Schwartz L, Ricci S et al (2007) Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 24:4293-4300
    • (2007) J Clin Oncol , vol.24 , pp. 4293-4300
    • Abou-Alfa, J.K.1    Schwartz, L.2    Ricci, S.3
  • 4
    • 34548322506 scopus 로고    scopus 로고
    • Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC)
    • Abstract 3546
    • Faivre SJ et al (2007) Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). Proc Am Soc Clin Oncol Abstract 3546
    • (2007) Proc Am Soc Clin Oncol
    • Faivre, S.J.1    Al, E.2
  • 5
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S et al (2007) Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 6:734-745
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1
  • 6
    • 7244250405 scopus 로고    scopus 로고
    • Angiogenesis and hepatocellular carcinoma
    • Semela D et al (2004) Angiogenesis and hepatocellular carcinoma. J Hepatol 41:864-880
    • (2004) J Hepatol , vol.41 , pp. 864-880
    • Semela, D.1
  • 7
    • 1442290121 scopus 로고    scopus 로고
    • Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1a
    • Moon EJ et al (2004) Hepatitis B virus X protein induces angiogenesis by stabilizing hypoxia-inducible factor-1a. FASEB J 18:382-384
    • (2004) FASEB J , vol.18 , pp. 382-384
    • Moon, E.J.1
  • 8
    • 0032714311 scopus 로고    scopus 로고
    • KDR/Flk-1 is a major regulator of vascular endothelial growth factor-induced tumor development and angiogenesis in murine hepatocellular carcinoma cells
    • Yoshiji H et al (1999) KDR/Flk-1 is a major regulator of vascular endothelial growth factor-induced tumor development and angiogenesis in murine hepatocellular carcinoma cells. Hepatology 30:1179-1186
    • (1999) Hepatology , vol.30 , pp. 1179-1186
    • Yoshiji, H.1
  • 9
    • 0031805801 scopus 로고    scopus 로고
    • Angiogenesis in hepatocellular carcinoma: An experimental study in the chick embryo chorioallantoic membrane
    • Marzullo A et al (1998) Angiogenesis in hepatocellular carcinoma: an experimental study in the chick embryo chorioallantoic membrane. Int J Oncol 13:17-21
    • (1998) Int J Oncol , vol.13 , pp. 17-21
    • Marzullo, A.1
  • 10
    • 0031737369 scopus 로고    scopus 로고
    • Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cells
    • Yoshiji H et al (1998) Vascular endothelial growth factor tightly regulates in vivo development of murine hepatocellular carcinoma cells. Hepatology 28:1489-1496
    • (1998) Hepatology , vol.28 , pp. 1489-1496
    • Yoshiji, H.1
  • 11
    • 0034219429 scopus 로고    scopus 로고
    • Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues
    • Yamaguchi R et al (2000) Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues. Oncol Rep 7:725-729
    • (2000) Oncol Rep , vol.7 , pp. 725-729
    • Yamaguchi, R.1
  • 12
    • 0033918376 scopus 로고    scopus 로고
    • Detection of vascular endothelial growth factor and its receptor expression in human hepatocellular carcinoma biopsy specimens
    • Shimamura T et al (2000) Detection of vascular endothelial growth factor and its receptor expression in human hepatocellular carcinoma biopsy specimens. J Gastroenterol Hepatol 15:640-646
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 640-646
    • Shimamura, T.1
  • 13
    • 0038374813 scopus 로고    scopus 로고
    • Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
    • Mitsuhashi N et al (2003) Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology 37:1105-1113
    • (2003) Hepatology , vol.37 , pp. 1105-1113
    • Mitsuhashi, N.1
  • 14
    • 18144401256 scopus 로고    scopus 로고
    • Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584
    • Liu Y et al (2005) Both antiangiogenesis- and angiogenesis-independent effects are responsible for hepatocellular carcinoma growth arrest by tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res 65:3691-3699
    • (2005) Cancer Res , vol.65 , pp. 3691-3699
    • Liu, Y.1
  • 15
    • 30444451162 scopus 로고    scopus 로고
    • ZD6474 inhibits proliferation and invasion of human hepatocellular carcinoma cells
    • Giannelli G et al (2006) ZD6474 inhibits proliferation and invasion of human hepatocellular carcinoma cells. Biochem Pharmacol 71:479-485
    • (2006) Biochem Pharmacol , vol.71 , pp. 479-485
    • Giannelli, G.1
  • 16
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, induces tumor cell apoptosis in hepatocellular carcinoma moded PLC/PRF/5
    • Liu L et al (2006) Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, induces tumor cell apoptosis in hepatocellular carcinoma moded PLC/PRF/5. Cancer Res 66:11851-11858
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1
  • 17
    • 19944432263 scopus 로고    scopus 로고
    • Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis
    • Schiffer E et al (2005) Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis. Hepatology 41:307-314
    • (2005) Hepatology , vol.41 , pp. 307-314
    • Schiffer, E.1
  • 18
    • 34547102484 scopus 로고    scopus 로고
    • Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
    • Zhu AX et al (2007) Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer 110:581-589
    • (2007) Cancer , vol.110 , pp. 581-589
    • Zhu, A.X.1
  • 19
    • 34548150925 scopus 로고    scopus 로고
    • Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
    • Thomas MB et al (2007) Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 110:1059-1067
    • (2007) Cancer , vol.110 , pp. 1059-1067
    • Thomas, M.B.1
  • 20
    • 0028318189 scopus 로고
    • Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice
    • Rogler CE et al (1994) Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice. J Biol Chem 269:13779-13784
    • (1994) J Biol Chem , vol.269 , pp. 13779-13784
    • Rogler, C.E.1
  • 21
    • 0346725866 scopus 로고    scopus 로고
    • The role of the IGF axis in hepatocarcinogenesis
    • Scharf JG et al (2003) The role of the IGF axis in hepatocarcinogenesis. Horm Metab Res 35:685-693
    • (2003) Horm Metab Res , vol.35 , pp. 685-693
    • Scharf, J.G.1
  • 22
    • 33750605628 scopus 로고    scopus 로고
    • Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib
    • Desbois-Mouthon C et al (2006) Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib. Int J Cancer 119:2557-2566
    • (2006) Int J Cancer , vol.119 , pp. 2557-2566
    • Desbois-Mouthon, C.1
  • 23
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S et al (2006) Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 5:671-688
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1
  • 24
    • 11144236505 scopus 로고    scopus 로고
    • MTOR and P70 S6 kinase expression in primary liver neoplasms
    • Sahin F et al (2004) mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res 10:8421-8425
    • (2004) Clin Cancer Res , vol.10 , pp. 8421-8425
    • Sahin, F.1
  • 25
    • 34047118033 scopus 로고    scopus 로고
    • Vascular remodelling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
    • Semela D et al (2007) Vascular remodelling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 46:840-848
    • (2007) J Hepatol , vol.46 , pp. 840-848
    • Semela, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.