Critical review of Clara cell protein: Sound science?

Biomarkers

Volumn 13, Issue 3, 2008, Pages 237-243

  Bernard, Alfred ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CLARA CELL PROTEIN;

BODY MASS; CIRCADIAN RHYTHM; CONFOUNDING VARIABLE; DIAGNOSTIC VALUE; DOSE RESPONSE; EXERCISE; HUMAN; KIDNEY FUNCTION; LUNG INJURY; MEDICAL RESEARCH; NON INVASIVE MEASUREMENT; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; SEX RATIO;

ANIMALS; BIOLOGICAL MARKERS; BIOMEDICAL RESEARCH; ENVIRONMENTAL EXPOSURE; HUMANS; INFLAMMATION; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; UTEROGLOBIN;

EID: 42349111504     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.1080/13547500801950793     Document Type: Review

References (34)

1. Arsalane, K., Broeckaert, F., Knoops, B., Clippe, A., Buchet, JP and Bernard, A. (1999) Increased serum and urinary concentrations of lung Clara cell protein in rats acutely exposed to ozone. Toxicology and Applied Pharmacology, 159, pp. 169-174.
2. Bergamaschi, E., De Palma, G., Mozzoni, P., Vanni, S., Vettori, MV, Broeckaert, F., Bernard, A. and Mutti, A. (2001) Polymorphism of quinone-metabolizing enzymes and susceptibility to ozone-induced acute effects. American Journal of Respiratory & Critical Care Medicine, 163, pp. 1426-1431.
3. Bernard, A., Roels, H., Buchet, JP and Lauwerys, R. (1992) Decrease of serum Clara cell protein in smokers. Lancet, 339, p. 1620.
4. Bernard, A., Thielemans, N., Lauwerys, R., Vandeleene, B. and Lambert, AE. (1993) The renal handling of protein 1 (Clara cell protein): Effect of age, sex and renal dysfunction. Contributions to Nephrology, 101, pp. 66-70.
5. Bernard, AM, Roels, HA, Buchet, JP and Lauwerys, RR. (1994) Serum Clara cell protein: An indicator of bronchial cell dysfunction caused by tobacco smoking. Environmental Research, 66, pp. 96-104.
6. Bernard, AM, Gonzalez-Lorenzo, JM, Siles, E., Trujillano, G. and Lauwerys, R. (1994) Early decrease of serum Clara cell protein in silica-exposed workers. European Respiratory Jounal, 7, pp. 1932-1937.
7. Bernard, A., Hermans, C. and Van Houte, G. (1997) Transient increase of serum Clara cell protein (CC16) after exposure to smoke. Occupational Environmental Medicine, 54, pp. 63-65.
8. Bernard, A., Carbonnelle, S., Michel, O., Higuet, S., De Burbure, C., Buchet, JP, Hermans, C., Dumont, X. and Doyle, I. (2003) Lung hyperpermeability and asthma prevalence in schoolchildren: Unexpected associations with the attendance at indoor chlorinated swimming pools. Occupational & Environmental Medicine, 60, pp. 385-394.
9. Bernard, A., Carbonnelle, S., Nickmilder, M. and de Burbure, C. (2005) Non-invasive biomarkers of pulmonary damage and inflammation: application to children exposed to ozone and trichloramine. Toxicology & Applied Pharmacology, 206, pp. 185-190.
10. Bernard, A., Carbonnelle, S., de Burbure, C., Michel, O. and Nickmilder, M. (2006) Chlorinated pool attendance, atopy, and the risk of asthma during childhood. Environmental Health Perspectives., 114, pp. 1567-1573.
11. Bernard, A. (2007) Chlorination products: Emerging links with allergic diseases. Current Medicinal Chemistry, 14, pp. 1771-1782.
12. Bernard, A., Carbonnelle, S., Dumont, X. and Nickmilder, M. (2007) Infant swimming practice, pulmonary epithelium integrity, and the risk of allergic and respiratory diseases later in childhood. Pediatrics, 119, pp. 1095-1103.
13. Berthoin, K., Broeckaert, F., Robin, M., Haufroid, V., De Burbure, C. and Bernard, A. (2004) Serum pneumoproteins and biomarkers of exposure to urban air pollution: A cross-sectional comparison of policemen and foresters. Biomarkers, 9, pp. 341-352.
14. Blomberg, A., Mudway, I., Svensson, M., Hagenbjork-Gustafsson, A., Thomasson, L., Helleday, R., Dumont, X., Forsberg, B., Nordberg, G. and Bernard, A. (2003) Clara cell protein as a biomarker for ozone-induced lung injury in humans. European Respiratory Journal, 22, pp. 883-888.
15. Broeckaert, F., Arsalane, K., Hermans, C., Bergamaschi, E., Brustolin, A., Mutti, A. and Bernard, A. (1999) Lung epithelial damage at low concentrations of ambient ozone. Lancet, 353, pp. 900-901.
16. Broeckaert, F., Arsalane, K., Hermans, C., Bergamaschi, E., Brustolin, A., Mutti, A. and Bermard, A. (2000) Serum clara cell protein: A sensitive biomarker of increased lung epithelium permeability caused by ambient ozone. Environmental Health Perspectives, 108, pp. 533-537.
17. Broeckaert, F., Clippe, A., Wattiez, R., Falmagne, P. and Bernard, A. (2003) Lung hyperpermeability, Clara-cell secretory potein (CC16), and susceptibility to ozone of five inbred strains of mice. Inhalation Toxicology, 15, pp. 1209-1230.
18. Carbonnelle, S., Francaux, M., Doyle, I., Dumont, X., de Burbure, C., Morel, G., Michel, O. and Bernard, A. (2002) Changes in serum pneumoproteins caused by short-term exposures to nitrogen trichloride in indoor chlorinated swimming pools. Biomarkers, 7, pp. 464-478.
19. Helleday, R., Segerstedt, B., Forsberg, B., Mudway, I., Nordberg, G., Bernard, A. and Blomberg, A. (2006) Exploring the time dependence of serum clara cell protein as a biomarker of pulmonary injury in humans. Chest, 130, pp. 672-675.
20. Hermans, C. and Bernard, A. (1996) Clara cell protein (CC16): characteristics and potential applications as biomarker of lung toxicity. Biomarkers, 1, pp. 3-8.
21. Hermans, C. and Bernard, A. (1998) Pneumoproteinaemia: A new perspective in the assessment of lung disorders. European Respiratory Journal, 1, pp. 801-803.
22. Hermans, C. and Bernard, A. (1999) Lung epithelium-specific proteins: characteristics and potential applications as markers. American Journal of Respiratory & Critical Care Medicine, 159, pp. 646-678.
23. Hermans, C., Aly, O., Nyberg, BI, Peterson, C. and Bernard, A. (1998) Determinants of Clara cell protein (CC16) concentration in serum: A reassessment with two different immunoassays. Clinica Chimica Acta, 272, pp. 101-110.
24. Lagerkvist, BJ, Bernard, A., Blomberg, A., Bergstrom, E., Forsberg, B., Holmstrom, K., Karp, K., Lundstrom, NG, Segerstedt, B., Svensson, M. and Nordberg, G. (2004) Pulmonary epithelial integrity in children: relationship to ambient ozone exposure and swimming pool attendance. Environmental Health Perspectives, 112, pp. 1768-1771.
25. LaKind, JS, Holgate, ST, Ownby, DR, Mansur, AH, Helms, PJ, Pyatt, D. and Hays, SM. (2007) A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers, 12, pp. 445-467.
26. Lesur, O., Langevin, S., Berthiaume, Y., Legare, M., Skrobik, Y., Bellemare, JF, Levy, B., Fortier, Y., Lauzier, F., Bravo, G., Nickmilder, M., Rousseau, E. and Bernard, A. (2006) Critical Care Research Group of the Quebec Respiratory Health Network. Outcome value of Clara cell protein in serum of patients with acute respiratory distress syndrome. Intensive Care Medicine, 32, pp. 1167-1174.
27. Mattsson, J., Remberger, M., Andersson, O., Sundberg, B. and Nord, M. (2005) Decreased serum levels of Clara cell secretory protein (CC16) are associated with bronchiolitis obliterans and may permit early diagnosis in patients after allogenic stem-cell transplantation. Transplantation, 79, pp. 1411-1416.
28. Mutti, A., Corradi, M., Goldoni, M., Vettori, MV, Bernard, A. and Apostoli, P. (2006) Exhaled metallic elements and serum pneumoproteins in asymptomatic smokers and patients with COPD or asthma. Chest, 129, pp. 1288-1297.
29. Nanson, CJ, Burgess, JL, Robin, M. and Bernard, AM. (2001) Exercise alters serum pneumoprotein concentrations. Respiratory Physiology, 127, pp. 259-265.
30. Nomori, H., Horio, H., Takagi, M., Kobayashi, R. and Hirabayashi, Y. (1996) Clara cell protein correlation with hyperlipidemia. Chest, 110, pp. 680-684.
31. Nord, M., Schubert, K., Cassel, TN, Andersson, O. and Riise, GC. (2002) Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients. Transplantation, 73, pp. 1264-1269.
32. Robin, M., Dong, P., Hermans, C., Bernard, A., Bersten, AD and Doyle, IR. (2002) Serum levels of CC16, SP-A and SP-B reflect tobacco-smoke exposure in asymptomatic subjects. European Respiratory Journal, 20, pp. 1152-1161.
33. Steiner, D., Jeggli, S., Tschopp, A., Bernard, A., Oppliger, A., Hilfiker, S. and Hotz, P. (2005) Clara cell protein and surfactant protein B in garbage collectors and in wastewater workers exposed to bioaerosols. International Archives of Occupational & Environmental Health, 78, pp. 189-197.
34. Yang, KD, Ou, CY, Chang, JC, Chen, RF, Liu, CA, Liang, HM, Hsu, TY, Chen, LC and Huang, SK. (2007) Infant frequent wheezing correlated to Clara cell protein 10 (CC10) polymorphism and concentration, but not allergy sensitization, in a perinatal cohort study. J Allergy Clinical Immunology, 120, pp. 842-848.