Clara cell protein as a biomarker for ozone-induced lung injury in humans

European Respiratory Journal

Volumn 22, Issue 6, 2003, Pages 883-888

  Blomberg, Anders ^a   Mudway, I ^d   Svensson, M ^b   Hagenbjork Gustafsson A ^c   Thomasson, L ^c   Helleday, R ^a   Dumont, X ^e   Forsberg, B ^b   Nordberg, G ^b   Bernard, A ^e  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Air pollution; Biomarkers; Clara cell protein; Lung permeability; Ozone

Indexed keywords

BIOLOGICAL MARKER; CLARA CELL PROTEIN; OZONE;

ADULT; ARTICLE; BLOOD SAMPLING; CELL MEMBRANE PERMEABILITY; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DIAGNOSTIC VALUE; ENVIRONMENTAL EXPOSURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION TEST; LUNG INJURY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SPIROMETRY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VITAL CAPACITY;

EID: 10744222285     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.03.00048203     Document Type: Article

References (30)

1. Hazbun ME, Hamilton R, Holian A, Eschenbacher WL. Ozone-induced increases in substance P and 8-epiprostaglandin F2 alpha in the airways of human subjects. Am J Respir Cell Mol Biol 1993; 9: 568-572.
2. Seal E Jr, McDonnell WF, House DE, et al. The pulmonary response of white and black adults to six concentrations of ozone. Am Rev Respir Dis 1993; 147: 804-810.
3. Koren HS, Devlin RB, Becker S, Perez R, McDonnell WF. Time-dependent changes of markers associated with inflammation in the lungs of humans exposed to ambient levels of ozone. Toxicol Pathol 1991; 19: 406-411.
4. Blomberg A, Mudway IS, Nordenhäll C, et al. Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur Respir J 1999; 13: 1418-1428.
5. Mudway IS, Stenfors N, Blomberg A, et al. Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: a comparison of healthy and mild asthmatic subjects. Free Radic Biol Med 2001; 31: 962-974.
6. Schelegle ES, Siefkin AD, McDonald RJ. Time course of ozone-induced neutrophilia in normal humans. Am Rev Respir Dis 1991; 143: 1353-1358.
7. Stenfors N, Pourazar J, Blomberg A, et al. Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir Med 2002; 96: 352-358.
8. Balmes JR, Chen LL, Scannell C, et al. Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 1996; 153: 904-909.
9. Holz O, Jorres RA, Timm P, et al. Ozone-induced airway inflammatory changes differ between individuals and are reproducible. Am J Respir Crit Care Med 1999; 159: 776-784.
10. Nightingale JA, Rogers DF, Barnes PJ. Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects. Thorax 1999; 54: 1061-1069.
11. McBride DE, Koenig JQ, Luchtel DL, Williams PV, Henderson WR Jr. Inflammatory effects of ozone in the upper airways of subjects with asthma. Am J Respir Crit Care Med 1994; 149: 1192-1197.
12. Frampton MW, Balmes JR, Cox C, et al. Effects of ozone on normal and potentially sensitive human subjects. Part III: Mediators of inflammation in bronchoalveolar lavage fluid from nonsmokers, smokers, and asthmatic subjects exposed to ozone: a collaborative study. Res Rep Health Eff Inst 1997; 78: 73-79.
13. Montuschi P, Nightingale JA, Kharitonov SA, Barnes PJ. Ozone-induced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radic Biol Med 2002; 33: 1403-1408.
14. Graham DE, Koren HS. Biomarkers of inflammation in ozone-exposed humans. Comparison of the nasal and bronchoalveolar lavage. Am Rev Respir Dis 1990; 142: 152-156.
15. Hiltermann JT, Lapperre TS, van Bree L, et al. Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma. Free Radic Biol Med 1999; 27: 1448-1454.
16. Hermans C, Bernard A. Lung epithelium-specific proteins: characteristics and potential applications as markers. Am J Respir Crit Care Med 1999; 159: 646-678.
17. Broeckaert F, Bernard A. Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker. Clin Exp Allergy 2000; 30: 469-475.
18. Hermans C, Petrek M, Kolek V, et al. Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis. Eur Respir J 2001; 18: 507-514.
19. Robin M, Dong P, Hermans C, Bernard A, Bersten AD, Doyle IR. Serum levels of CC16, SP-A and SP-B reflect tobacco-smoke exposure in asymptomatic subjects. Eur Respir J 2002; 20: 1152-1161.
20. Carbonnelle S, Francaux M, Doyle I, et al. Changes of serum pneumoproteins caused by short-term exposures to nitrogen trichloride in indoor chlorinated pools. Biomarkers 2002; 7: 464-478.
21. Broeckaert F, Arsalane K, Hermans C, et al. Lung epithelial damage at low concentrations of ambient ozone. Lancet 1999; 353: 900-901.
22. American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am Rev Respir Dis 1991; 144: 1202-1218.
23. Bernard A, Marchandise FX, Depelchin S, Lauwerys R, Sibille Y. Clara cell protein in serum and bronchoalveolar lavage. Eur Respir J 1992; 5: 1231-1238.
24. Hermans C, Aly O, Nyberg BI, Peterson C, Bernard A. Determinants of Clara cell protein (CC16) concentration in serum: a reassessment with two different immunoassays. Clin Chim Acta 1998; 272: 101-110.
25. Stenfors N. Differential airway inflammatory responses to ozone and diesel exhaust in healthy and asthmatic subjects. Umeå: Umeå University, Sweden, 2002. PhD Thesis.
26. Hermans C, Bernard A. Pneumoproteinaemia: a new perspective in the assessment of lung disorders. Eur Respir J 1998; 11: 801-803.
27. Broeckaert F, Arsalane K, Hermans C, et al. Serum clara cell protein: a sensitive biomarker of increased lung epithelium permeability caused by ambient ozone. Environ Health Perspect 2000; 108: 533-537.
28. Hazucha MJ, Bates DV, Bromberg PA. Mechanism of action of ozone on the human lung. J Appl Physiol 1989; 67: 1535-1541.
29. Krishna MT, Springall D, Meng QH, et al. Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans. Am J Respir Crit Care Med 1997; 156: 943-950.
30. Nanson CJ, Burgess JL, Robin M, Bernard AM. Exercise alters serum pneumoproteins concentrations. Respir Physiol 2001; 127: 259-265.