Effects of the cannabinoid antagonist AM281 on systemic hemodynamics and mortality rate in streptozotocin-induced diabetic rats with endotoxic shock: Comparison between non-diabetic and diabetic rats

Acta Anaesthesiologica Scandinavica

Volumn 52, Issue 5, 2008, Pages 664-672

  Kadoi, Y ^a   Hinohara, H ^a   Kunimoto, F ^a   Saito, S ^a  

^a GUNMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Antagonist; Cannabinoid; Diabetic; Endotoxic shock; Mortality

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; BACTERIUM LIPOPOLYSACCHARIDE; CANNABINOID RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY FLOW; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; HEMODYNAMICS; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPTIC SHOCK; SEPTICEMIA; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CAROTID ARTERY, INTERNAL; DIABETES MELLITUS, EXPERIMENTAL; HEART RATE; HEMODYNAMICS; INTERLEUKIN-1BETA; MALE; MORPHOLINES; PYRAZOLES; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; REGIONAL BLOOD FLOW; SHOCK, SEPTIC; SODIUM NITRITE; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 42249106216     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2007.01573.x     Document Type: Article

References (24)

1. Marik PE, Raghavan M. Stress-hyperglycemia, insulin and immunomodulation in sepsis. Intern Care Med 2004 30 : 748 56.
2. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003 348 : 138 50.
3. Loisa P, Rinne T, Laine S et al. Anti-inflammatory cytokine response and the development of multiple organ failure in severe sepsis. Acta Anaesthesiol Scand 2003 47 : 319 25.
4. Jacobson S, Johansson G, Winso O. Primary sepsis in a university hospital in northern Sweden: a retrospective study. Acta Anaesthesiol Scand 2004 48 : 960 7.
5. Brix-Christensen V, Gjedsted J, Andersen SK et al. Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: the contribution of essential organs. Acta Anaesthesiol Scand 2005 49 : 991 8.
6. Norhammar AM, Ryden L, Malmberg K. Admission plasma glucose. Independent risk factor for long-term prognosis after myocardial infarction even in nondiabetic patients. Diabetes Care 1999 22 : 1827 31.
7. Malmberg K. Prospective randomized study of intensive insulin treatment on long-term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI Study Group. Br Med J 1997 314 : 1512 5.
8. Capes SE, Hunt D, Malmberg K et al. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001 32 : 2426 32.
9. Van den Berghe G, Wouters PJ, Weekers F et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001 345 : 1359 67.
10. Kadoi Y, Goto F. Effects of selective inducible nitric oxide synthase inhibition on systemic hemodynamics and mortality rate on endotoxic shock in streptozotocin- induced diabetic rats. Shock 2007 28 : 602 10.
11. Kadoi Y, Hinohara H, Kunimoto F et al. Effects of AM 281, a cannabinoid antagonist, on systemic hemodynamics, internal carotid artery blood flow and mortality rate in septic shock in rats. Br J Anesth 2005 94 : 563 8.
12. Kadoi Y, Hinohara H, Kunimoto F et al. A cannabinoid antagonist, AM 281, reduces mortality rate and neurological dysfunction after cecal ligation and puncture in rats. Crit Care Med 2005 33 : 2629 36.
13. Gando S, Hattori Y, Akaishi Y et al. Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation. J Pharmacol Exp Ther 1997 282 : 475 84.
14. Kadoi Y, Goto F. Selective inducible nitric oxide inhibition can restore hemodynamics, but does not improve neurological dysfunction in experimentally-induced septic shock in rats. Anesth Analg 2004 99 : 212 20.
15. Kadoi Y, Saito S, Kunimoto F et al. Impairment of the brain beta-adrenergic system during experimental endotoxemia. J Surg Res 1996 61 : 496 502.
16. Kadoi Y, Saito S, Kawahara F et al. G-protein coupled receptor kinase 2 is altered during septic shock in rats. J Surg Res 2002 108 : 69 76.
17. Gifford An Bruneus M, Gatley SJ, Lan R et al. Large receptor reserve for cannabinoid actions in the central nervous system. J Pharmacol Exp Ther 1999 288 : 478 83.
18. Esposito K, Nappo F, Marfella R et al. Inflammatory cytokine concentrations are actually increased by hyperglycemia in humans: role of oxidative stress. Circulation 2002 106 : 2067 72.
19. Bardell AL, Macleod KM. Evidence for inducible nitric-oxide synthase expression and activity in vascular smooth muscle of streptozotocin-diabetic rats. J Pharmacol Exp Ther 2001 296 : 252 9.
20. Kirkeboen KA, Strand OA. The role of nitric oxide in sepsis- an overview. Acta Anaesthesiol Scand 1999 43 : 275 88.
21. Javeshghani D, Magder S. Regional changes in constitutive nitric oxide synthase and the hemodynamic consequences of its inhibition in lipopolysaccharide-treated pigs. Shock 2001 16 : 232 8.
22. Pollard V, Prough DS, Deyo DJ et al. Cerebral blood flow during experimental endotoxemia in volunteers. Crit Care Med 1997 25 : 1700 6.
23. Bowton DL, Bertels NH, Prough DS et al. Cerebral blood flow is reduced in patients with sepsis syndrome. Crit Care Med 1989 17 : 399 403.
24. Varga K, Wahner JA, Bridgen T et al. Platelet-and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J 1998 12 : 1035 44.