Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: The contribution of essential organs

Acta Anaesthesiologica Scandinavica

Volumn 49, Issue 7, 2005, Pages 991-998

  Brix Christensen, Vibeke ^a   Gjedsted, J ^a,b   Andersen, S K ^a   Vestergaard, C ^a   Nielsen, J ^a   Rix, T ^a   Nyboe, R ^a   Andersen, N T ^b   Larsson, A ^c   Schmitz, O ^b   Tonnesen E ^a,b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c AALBORG UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cytokines; Hyperglycemia; Insulin; LPS; mRNA; Pigs; Protein

Indexed keywords

CYTOKINE; FATTY ACID; GLUCOSE; HYDROCORTISONE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTOXEMIA; HEART; HYPERGLYCEMIA; HYPERINSULINEMIA; IMMUNE RESPONSE; INFLAMMATION; KIDNEY; LIVER; LUNG; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; SWINE;

ANIMALS; BLOOD GLUCOSE; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; FATTY ACIDS, NONESTERIFIED; HYDROCORTISONE; HYPERGLYCEMIA; HYPERINSULINISM; INFLAMMATION; INSULIN; RNA, MESSENGER; SWINE;

EID: 23044507179     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2005.00749.x     Document Type: Article

References (27)

1. Umpierrez GE, Isaacs SD, Bazargan N, You X, Thaler LM, Kitabchi AE. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 2002; 87: 978-82.
2. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003; 78: 1471-8.
3. Hattori Y, Hattori S, Sato N, Kasai K. High-glucose-induced nuclear factor kappaB activation in vascular smooth muscle cells. Cardiovasc Res 2000; 46: 188-97.
4. Van den Berghe G, Wouters R, Weekers F et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345: 1359-67.
5. Van den Berghe G, Wouters PJ, Bouillon R et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003; 31: 359-66.
6. Dandona P, Aljada A, Mohanty P. The anti-inflammatory and potential antiatherogenic effect of insulin: a new paradigm. Diabetologia 2002; 45: 924-30.
7. Esposito K, Nappo F, Marfella R et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans. Role of oxidative stress. Circulation 2002; 106: 2067-72.
8. Stentz FB, Umpierrez GE, Cuervo R, Kitabchi AE. Proinflammatory cytokines, markers of cardiovasxular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 2004; 53: 2079-86.
9. Brix-Christensen V, Andersen SK, Andersen R et al. Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model. Anesthesiology 2004; 100: 861-70.
10. Hansen IL, Cryer PE, Rizza RA. Comparison of insulin-mediated and glucose-mediated glucose disposal in patients with insulin-dependent diabetes mellitus in nondiabetic subjects. Diabetes 1985; 34: 751-5.
11. McCormack G, Moriarty D, O'Donoghue DP, McCormick PA, Sheahan K, Baird AW. Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflamm Res 2001; 50: 491-5.
12. Smith PK, Krohn RI, Hermanson GT et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985; 150: 76-85.
13. Brix-Christensen V, Vestergaard C, Chew M et al. Plasma cytokines do not reflect expression of pro- and anti-inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs. Acta Anaesthesiol Scand 2003; 47: 525-31.
14. Krogh-Madsen R, Moller K, Dela F, Kronborg G, Jauffred S, Pedersen BK. Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-alpha, and FFAs to low-dose endotoxemia in humans. Am J Physiol Endocrinol Metab 2004; 286: 766-72.
15. Soop M, Duxbury H, Agwunobi AO et al. Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab 2002; 282: 1276-85.
16. Marfella R, Esposito K, Giunta R et al. Circulating adhesion molecules in humans. Role of hyperglycemia and hyperinsulinemia. Circulation 2000; 101: 2247-51.
17. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548-56.
18. Wan L, Di Bellomo RG, Ronco C. The pathogenesis of septic acute renal failure. Current Opinion Crit Care 2003; 9: 496-502.
19. Baker RC, Armstrong MA, Allen SJ, McBride WT. Role of the kidney in perioperative inflammatory responses. Br J Anaesth 2002; 88: 330-4.
20. Pastor CM, Billiar TR, Losser MR, Payen DM. Liver injury during sepsis. J Crit Care 1995; 10: 183-97.
21. Busam KJ, Bauer TM, Bauer J, Gerok W, Decker KJ. Interleukin-6 release by rat liver macrophages. Hepatol 1990; 11: 367-73.
22. Luster AD. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338: 436-45.
23. Cavaillon JM, Munoz C, Fitting C, Misset B, Carlet J. Circulating cytokines: the tip of the iceberg? Circ Shock 1992; 38: 145-52.
24. Kukielka GL, Smith W, Manning AM, Youker KA, Michael LH, Entman ML. Induction of interleukin-6 synthesis in the myocardium. Potential role in postreperfusion inflammatory injury. Circulation 1995; 92: 1866-75.
25. Hirsch IB. Effect of insulin therapy on nonglycemic variables during acute illness. Endocr Pract 2004; 10: 63-70.
26. Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 2004; 89: 219-26.
27. Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. JAMA 2003; 290: 2041-7.