The value of exhaled nitric oxide in predicting bronchial hyperresponsiveness in children

Journal of Asthma

Volumn 45, Issue 3, 2008, Pages 191-195

  Ramser, Michel ^a   Hammer, Juerg ^a   Amacher, Arnold ^a   Trachsel, Daniel ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Bronchial hyperresponsiveness; Exhaled nitric oxide; FeNO; Lung function; Methacholine

Indexed keywords

METHACHOLINE; NITRIC OXIDE; NITROGEN;

ADOLESCENT; AGE DISTRIBUTION; ARTICLE; ATOPY; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CHILD; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EXERCISE INDUCED ASTHMA; EXHALATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; OUTPATIENT CARE; PREDICTION; PROVOCATION TEST; SINGLE BREATH NITROGEN TEST;

ADOLESCENT; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; CHILD; EXERCISE TEST; EXHALATION; FEMALE; HUMANS; HYPERSENSITIVITY; MALE; METHACHOLINE CHLORIDE; NITRIC OXIDE; PLETHYSMOGRAPHY, WHOLE BODY; PREDICTIVE VALUE OF TESTS; SPIROMETRY;

EID: 42249101035     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.1080/02770900801890273     Document Type: Article

References (36)

1. Eliasson AH, Phillips YY, Rajagopal KR, Howard RS. Sensitivity and specificity of bronchial provocation testing. An evaluation of four techniques in exercise-induced bronchospasm. Chest 1992; 102:347-355.
2. Godfrey S, Springer C, Noviski N, Maayan C, Avital A. Exercise but not methacholine differentiates asthma from chronic lung disease in children. Thorax 1991; 46:488-492.
3. Benckhuijsen J, van den Bos JW, van Velzen E, de Bruijn R, Aalbers R. Differences in the effect of allergen avoidance on bronchial hyperresponsiveness as measured by methacholine, adenosine 5′-monophosphate, and exercise in asthmatic children. Pediatr Pulmonol 1996; 22:147-153.
4. Doull IJ, Sandall D, Smith S, Schreiber J, Freezer NJ, Holgate ST. Differential inhibitory effect of regular inhaled corticosteroid on airway responsiveness to adenosine 5′ monophosphate, methacholine, and bradykinin in symptomatic children with recurrent wheeze. Pediatr Pulmonol 1997; 23:404-411.
5. Nielsen KG, Bisgaard H. The effect of inhaled budesonide on symptoms, lung function, and cold air and methacholine responsiveness in 2- to 5-year-old asthmatic children. Am J Respir Crit Care Med 2000; 162:1500-1506.
6. van den Berge M, Kerstjens HA, Meijer RJ, de Reus DM, Koeter GH, Kauffman HF, et al. Corticosteroid-induced improvement in the PC20 of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement to PC20 of methacholine. Am J Respir Crit Care Med 2001; 164:1127-1132.
7. Jones SL, Kittelson J, Cowan JO, Flannery EM, Hancox RJ, McLachlan CR, et al. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med 2001; 164:738-743.
8. Pijnenburg MW, Hofhuis W, Hop WC, de Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005; 60:215-218.
9. Pijnenburg MW, Bakker EM, Hop WC, de Jongste JC. Titrating steroids on exhaled nitric oxide in children with asthma. Am J Respir Crit Care Med 2005; 172:831-836.
10. Smith AD, Cowan JO, Brassett KP, Herbison GP, Taylor DR. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005; 352:2163-2173.
11. Zacharasiewicz A, Wilson N, Lex C, Erin EM, Li AM, Hansel T, et al. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005; 171:1077-1082.
12. Berkman N, Avital A, Breuer R, Bardach E, Springer C, Godfrey S. Exhaled nitric oxide in the diagnosis of asthma: comparison with bronchial provocation tests. Thorax 2005; 60:383-388.
13. Buchvald F, Hermansen MN, Nielsen KG, Bisgaard H. Exhaled nitric oxide predicts exercise-induced bronchoconstriction in asthmatic school children. Chest 2005; 128:1964-1967.
14. Deykin A, Massaro AF, Drazen JM, Israel E. Exhaled nitric oxide as a diagnostic test for asthma. Online versus offline techniques and effect of flow rate. Am J Respir Crit Care Med 2002; 165:1597-1601.
15. Dupont LJ, Demedts MG, Verleden GM. Prospective evaluation of the validity of exhaled nitric oxide for the diagnosis of asthma. Chest 2003; 123:751-756.
16. ElHalawani SM, Ly NT, Mahon RT, Amundson DE. Exhaled nitric oxide as a predictor of exercise-induced bronchoconstriction. Chest 2003; 124:639-643.
17. Smith AD, Cowan JO, Filsell S, McLachlan C, Monti-Sheehan G, Jackson P, et al. Diagnosing asthma. Comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med 2004; 169:473-478.
18. Colon-Semidey AJ, Marshik P, Crowley M, Katz R, Kelly HW. Correlation between reversibility of airway obstruction and exhaled nitric oxide levels in children with stable bronchial asthma. Pediatr Pulmonol 2000; 30:385-392.
19. Covar RA, Szefler SJ, Martin RJ, Sundstrom DA, Silkoff PE, Murphy J, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma. J Pediatr 2003; 142:469-475.
20. Dupont LJ, Rochette F, Demedts MG, Verleden GM. Exhaled nitric oxide correlates with airway hyperresponsiveness in steroid-naive patients with mild asthma. Am J Respir Crit Care Med 1998; 157:894-898.
21. Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax 1998; 53:91-95.
22. Leuppi JD, Downs SH, Downie SR, Marks GB, Salome CM. Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms. Thorax 2002; 57:518-523.
23. Rouhos A, Ekroos H, Karjalainen J, Sarna S, Sovijärvi ARA. Exhaled nitric oxide and exercise-induced bronchoconstriction in young male conscripts: association only in atopics. Allergy 2005; 60:1493-1498.
24. Steerenberg PA, Janssen NAH, de Meer G, Fischer PH, Nierkens S, van Loveren H, et al. Relationship between exhaled NO, respiratory symptoms, lung function, bronchial hyperresponsiveness, and blood eosinophilia in school children. Thorax 2003; 58:242-245.
25. Zietkowski Z, Bodzenta-Lukaszyk A, Tomasiak MM, Skiepko R, Szmitkowski M. Comparison of exhaled nitric oxide measurement with conventional tests in steroid-naive asthma patients. J Investig Allergol Clin Immunol 2006; 16:239-246.
26. del Giudice MM, Brunese FP, Piacentini GL, Pedullá M, Capristo C, Decimo F, et al. Fractional exhaled nitric oxide (FENO), lung function and airway hyperresponsiveness in naïve atopic asthmatic children. J Asthma 2004; 41:759-765.
27. Silvestri M, Spallarossa D, Battistini E, Brusasco V, Rossi GA. Dissociation between exhaled nitric oxide and hyperresponiveness in children with mild intermittent asthma. Thorax 2000; 55:484-488.
28. Spallarossa D, Battistini E, Silvestri M, Sabatini F, Fregonese L, Brazzola G, et al. Steroid-naive adolescents with mild intermittent allergic asthma have airway responsiveness and elevated exhaled nitric oxide levels. J Asthma 2003; 40:301-310.
29. van Den Toorn LM, Prins JB, Overbeck SE, Hoogsteden HC, de Jongste JC. Adolescents in clinical remission of atopic asthma have elevated exhaled nitric oxide levels and bronchial hyperresponsiveness. Am J Respir Crit Care Med 2000; 162:953-957.
30. Buchvald F, Eiberg H, Bisgaard H. Heterogeneity of FeNO response to inhaled steroid in asthmatic children. Clin Exp Allergy 2003; 33:1735-1740.
31. American Thoracic Society/European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005; 171:912-930.
32. ERS Task Force on Standardization of Clinical Exercise Testing. Clinical exercise testing with reference to lung disease: Indications, standardization and interpretation strategies. Eur Respir J 1997; 10:2662-2689.
33. Joseph-Bowen J, de Klerk NH, Firth MJ, Kendall GE, Holt PG, Sly PD. Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children. Am J Respir Crit Care Med 2004; 169:850-854.
34. O'Connor G, Sparrow D, Taylor D, Segal M, Weiss S. Analysis of dose-response curves to methacholine. Am Rev Respir Dis 1987; 136:1412-1417.
35. Leuppi JD, Salome CM, Jenkins CR, Koskela H, Brannan JD, Anderson SD, et al. Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. Eur Respir J 2001; 18:444-450.
36. Crimi E, Spanevello A, Neri M, Ind PW, Rossi GA, Brusasco V. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med 1998; 157:4-9.