-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
-
2
-
-
33644670748
-
Local treatment of malignant brain tumors using implantable chemotherapeutic polymers
-
Gallia GL, Brem S, Brem H. Local treatment of malignant brain tumors using implantable chemotherapeutic polymers. J. Natl Compr. Canc. Netw. 3, 721-728 (2005).
-
(2005)
J. Natl Compr. Canc. Netw
, vol.3
, pp. 721-728
-
-
Gallia, G.L.1
Brem, S.2
Brem, H.3
-
3
-
-
0036053691
-
Local treatment of brain tumors with targeted chimera cytotoxic proteins
-
Debinski W. Local treatment of brain tumors with targeted chimera cytotoxic proteins. Cancer Invest. 20, 801-809 (2002).
-
(2002)
Cancer Invest
, vol.20
, pp. 801-809
-
-
Debinski, W.1
-
4
-
-
0028859363
-
Human glioma cells over-express receptor for IL13 and are extremely sensitive to a novel chimeric protein composed of IL13 and Pseudomonas exotoxin
-
Debinski W, Obiri NI, Powers SK, Pastan I, Puri RK. Human glioma cells over-express receptor for IL13 and are extremely sensitive to a novel chimeric protein composed of IL13 and Pseudomonas exotoxin. Clin. Cancer Res. 1, 1253-1258 (1995).
-
(1995)
Clin. Cancer Res
, vol.1
, pp. 1253-1258
-
-
Debinski, W.1
Obiri, N.I.2
Powers, S.K.3
Pastan, I.4
Puri, R.K.5
-
5
-
-
33947547455
-
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: A report by the Cintredekin Besudotox Intraparenchymal Study Group
-
Kunwar S, Prados MD, Chang SM et al. Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group. J. Clin. Oncol. 25, 837-844 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 837-844
-
-
Kunwar, S.1
Prados, M.D.2
Chang, S.M.3
-
6
-
-
42249084323
-
Results from PRECISE: A randomized Phase 3 study in patients with first recurrent GBM comparing Cintredekin Besudotox administered via convection-enhanced delivery with Gliadel wafers
-
As in [5, this study establishes clinical efficacy of a recombinant cytotoxin in patients with glioblastoma multiforme GBM, ••
-
Kunwar S, Westphal M, Medhorn M et al. Results from PRECISE: a randomized Phase 3 study in patients with first recurrent GBM comparing Cintredekin Besudotox administered via convection-enhanced delivery with Gliadel wafers. Neuro-oncology 9, 531 (2007). •• As in [5], this study establishes clinical efficacy of a recombinant cytotoxin in patients with glioblastoma multiforme (GBM).
-
(2007)
Neuro-oncology
, vol.9
, pp. 531
-
-
Kunwar, S.1
Westphal, M.2
Medhorn, M.3
-
7
-
-
33845698912
-
Expression of nine tumour antigens in a series of human glioblastoma multiforme: Interest of EGFRvIII, IL-13Rα2, gp100 and TRP-2 for immunotherapy
-
Saikali S, Avril T, Collet B et al. Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Rα2, gp100 and TRP-2 for immunotherapy. J. Neurooncol. 81, 139-148 (2007).
-
(2007)
J. Neurooncol
, vol.81
, pp. 139-148
-
-
Saikali, S.1
Avril, T.2
Collet, B.3
-
8
-
-
33846886376
-
Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics
-
Demonstrates an interesting profile of antigens found in GBM suitable for targeting using multivalent vaccines, •
-
Zhang JG, Eguchi J, Kruse C et al. Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeutics. Clin. Cancer Res. 13, 566-575 (2007). • Demonstrates an interesting profile of antigens found in GBM suitable for targeting using multivalent vaccines.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 566-575
-
-
Zhang, J.G.1
Eguchi, J.2
Kruse, C.3
-
9
-
-
0344810314
-
Growth factor expression varies among high grade gliomas and normal brain: Epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy
-
Liu TF, Tatter SB, Willingham MC, Yang MY, Hu J, Frankel A. Growth factor expression varies among high grade gliomas and normal brain: epidermal growth factor receptor has excellent properties for interstitial fusion protein therapy. Mol. Cancer Ther. 2(8), 783-787 (2003).
-
(2003)
Mol. Cancer Ther
, vol.2
, Issue.8
, pp. 783-787
-
-
Liu, T.F.1
Tatter, S.B.2
Willingham, M.C.3
Yang, M.Y.4
Hu, J.5
Frankel, A.6
-
10
-
-
40749096452
-
IL-13 Receptor α-2, EphA2, and Fra-1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy
-
Establishes first ever documented trimolecular signature of GBM, ••
-
Wykosky J, Gibo DM, Stanton C, Debinski W. IL-13 Receptor α-2, EphA2, and Fra-1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy. Clin. Cancer Res. 14, 199-208 (2008). •• Establishes first ever documented trimolecular signature of GBM.
-
(2008)
Clin. Cancer Res
, vol.14
, pp. 199-208
-
-
Wykosky, J.1
Gibo, D.M.2
Stanton, C.3
Debinski, W.4
-
11
-
-
0037381008
-
Gene expression-based classification of malignant gliomas correlated better with survival than histological classification
-
Nutt CL, Mani DR, Betensky RA et al. Gene expression-based classification of malignant gliomas correlated better with survival than histological classification. Cancer Res. 63, 1602-1607 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 1602-1607
-
-
Nutt, C.L.1
Mani, D.R.2
Betensky, R.A.3
-
12
-
-
27644466229
-
EphA2 as a novel molecular marker and target in glioblastoma multiforme
-
Wykosky J, Gibo DM, Stanton C, Debinski W. EphA2 as a novel molecular marker and target in glioblastoma multiforme. Mol. Cancer Res. 3, 541-551 (2005).
-
(2005)
Mol. Cancer Res
, vol.3
, pp. 541-551
-
-
Wykosky, J.1
Gibo, D.M.2
Stanton, C.3
Debinski, W.4
-
13
-
-
33845332412
-
A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma
-
Liu F, Park PJ, Lai W et al. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res. 66, 10815-10823 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 10815-10823
-
-
Liu, F.1
Park, P.J.2
Lai, W.3
-
14
-
-
37549047649
-
A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor-expressing tumor cells
-
Wykosky J, Gibo DM, Debinski W. A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor-expressing tumor cells. Mol. Cancer Ther. 6, 3208-3218 (2007)
-
(2007)
Mol. Cancer Ther
, vol.6
, pp. 3208-3218
-
-
Wykosky, J.1
Gibo, D.M.2
Debinski, W.3
-
15
-
-
0344364573
-
Combination fusion protein therapy of refractory brain tumors: Demonstration of efficacy in cell culture
-
Liu TF, Willingham MC, Tatter SB et al. Combination fusion protein therapy of refractory brain tumors: demonstration of efficacy in cell culture. J. Neurooncol. 65(1), 77-85 (2003).
-
(2003)
J. Neurooncol
, vol.65
, Issue.1
, pp. 77-85
-
-
Liu, T.F.1
Willingham, M.C.2
Tatter, S.B.3
-
16
-
-
38649092392
-
Anti-glioblastoma effect of a recombinant bi-specific cytotoxin co-targeting human IL-13 and EGF receptors in a mouse xenograft model
-
Demonstrates better efficacy of double-targeting of GBM with recombinant cytotoxins, •
-
Stish BJ, Chen H, Shu Y, Panoskaltsis-Mortari A, Vallera DA. Anti-glioblastoma effect of a recombinant bi-specific cytotoxin co-targeting human IL-13 and EGF receptors in a mouse xenograft model. J. Neurooncol. 87(1), 51-61 (2008). • Demonstrates better efficacy of double-targeting of GBM with recombinant cytotoxins.
-
(2008)
J. Neurooncol
, vol.87
, Issue.1
, pp. 51-61
-
-
Stish, B.J.1
Chen, H.2
Shu, Y.3
Panoskaltsis-Mortari, A.4
Vallera, D.A.5
-
17
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11(1), 83-95 (2007).
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
di Tomaso, E.3
-
18
-
-
0035718735
-
VEGF-D is an X-linked/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme
-
Debinski W, Slagle-Webb B, Achen MG et al. VEGF-D is an X-linked/AP-1 regulated putative onco-angiogen in human glioblastoma multiforme. Mol. Med. 7, 598-608 (2001).
-
(2001)
Mol. Med
, vol.7
, pp. 598-608
-
-
Debinski, W.1
Slagle-Webb, B.2
Achen, M.G.3
-
19
-
-
33646260685
-
Using molecular information to guide brain tumor therapy
-
Mischel PS, Cloughesy T. Using molecular information to guide brain tumor therapy. Nat. Clin. Pract. Neurol. 2(5), 232-233 (2006).
-
(2006)
Nat. Clin. Pract. Neurol
, vol.2
, Issue.5
, pp. 232-233
-
-
Mischel, P.S.1
Cloughesy, T.2
-
20
-
-
23844528834
-
Personalized, multivalent, and more affordable: The globalization of vaccines
-
Debinski W. Personalized, multivalent, and more affordable: the globalization of vaccines. Clin. Cancer Res. 11, 5663-5664 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 5663-5664
-
-
Debinski, W.1
|