Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death

Biochemical and Biophysical Research Communications

Volumn 370, Issue 2, 2008, Pages 353-358

  Kim, Min Jung ^a   Park, Moon Taek ^a   Yoon, Chang Hwan ^a   Byun, Joo Yun ^a   Lee, Su Jae ^a  

^a Hanyang University   (South Korea)

Author keywords

Bak dependent cell death by sphingosine; Lck mediated conformational activation of Bak; Sphingolipid metabolites; Sphingosine induced mitochondrial cell death

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CYTOCHROME C; PROTEIN BAK; PROTEIN KINASE LCK; SMALL INTERFERING RNA; SPHINGOLIPID; SPHINGOSINE;

ARTICLE; CELL DEATH; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CONFORMATION; RNA INTERFERENCE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CYTOCHROMES C; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RNA, SMALL INTERFERING; SPHINGOSINE;

EID: 42249087767     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.03.084     Document Type: Article

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