Designing antibodies for the inhibition of gastrin activity in tumoral cell lines

International Journal of Cancer

Volumn 122, Issue 10, 2008, Pages 2351-2359

  Barderas, Rodrigo ^a   Shochat, Susana ^b   Timmerman, Peter ^c,d   Hollestelle, Martine J ^e   Martínez Torrecuadrada, Jorge L ^a   Höppener, Jo W M ^e   Altschuh, Danièle ^b   Meloen, Rob ^c,f   Casal, José Ignacio ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c Pepscan Systems   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antibody libraries; Antibody repertoire; Gastrin; Immunotherapy; Pancreatic cancer

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; DIPHTHERIA TOXOID; GASTRIN; MONOCLONAL ANTIBODY; BLOCKING ANTIBODY; GASTRIN 17; PEPTIDE LIBRARY;

ARTICLE; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CELL PROLIFERATION; COLORECTAL CANCER; GENE OVEREXPRESSION; GERM LINE; HUMAN; HUMAN CELL; PANCREAS CANCER; PRIORITY JOURNAL; STOMACH CANCER; ANIMAL; CELL CULTURE; COLON TUMOR; DRUG ANTAGONISM; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOUSE; PATHOLOGY; SPLEEN; SURFACE PLASMON RESONANCE;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; CELL PROLIFERATION; COLONIC NEOPLASMS; DIPHTHERIA TOXOID; ENZYME-LINKED IMMUNOSORBENT ASSAY; GASTRINS; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN VARIABLE REGION; MICE; PEPTIDE LIBRARY; RECEPTOR, CHOLECYSTOKININ B; SPLEEN; SURFACE PLASMON RESONANCE; TUMOR CELLS, CULTURED;

EID: 42149191152     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23395     Document Type: Article

References (24)

1. Varro A, Nemeth J, Bridson J, Lee C, Moore S, Dockray GJ. Processing of the gastrin precursor. Modulation of phosphorylated, sulfated, and amidated products. J Biol Chem 1990;265:21476-81.
2. Watson SA, Durrant LG, Morris DL. Growth-promoting action of gastrin on human colonic and gastric tumour cells cultured in vitro. Br J Surg 1988;75:342-5.
3. Seva C, Dickinson CJ, Yamada T. Growth-promoting effects of glycine-extended progastrin. Science 1994;265:410-12.
4. Smith JP, Fantaskey AP, Liu G, Zagon IS. Identification of gastrin as a growth peptide in human pancreatic cancer. Am J Physiol 1995;268:R135-R141.
5. Singh P, Walker JP, Townsend CM, Jr, Thompson JC. Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice. Cancer Res 1986;46:1612-16.
6. Smith JP, Solomon TE. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology 1988;95:1541-8.
7. Smith JP, Stock EA, Wotring MG, McLaughlin PJ, Zagon IS. Characterization of the CCK-B/gastrin-like receptor in human colon cancer. Am J Physiol 1996;271:R797-R805.
8. Konturek PC, Nikiforuk A, Kania J, Raithel M, Hahn EG, Muhldorfer S. Activation of NFκB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2. PPAR-γ and growth factors. Dig Dis Sci 2004;49:1075-83.
9. Harris JC, Gilliam AD, McKenzie AJ, Evans SA, Grabowska AM, Clarke PA, McWilliams DF, Watson SA. The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas. Cancer Res 2004;64:5624-31.
10. Ogasa M, Miyazaki Y, Hiraoka S, Kitamura S, Nagasawa Y, Kishida O, Miyazaki T, Kiyohara T, Shinomura Y, Matsuzawa Y. Gastrin activates nuclear factor κB (NFκB) through a protein kinase C dependent pathway involving NFκB inducing kinase, inhibitor κB (IκB) kinase, and tumour necrosis factor receptor associated factor 6 (TRAF6) in MKN-28 cells transfected with gastrin receptor. Gut 2003;52:813-19.
11. Watson SA, Michaeli D, Grimes S, Morris TM, Robinson G, Varro A, Justin TA, Hardcastle JD. Gastrimmune raises antibodies that neutralize amidated and glycine-extended gastrin-17 and inhibit the growth of colon cancer. Cancer Res 1996;56:880-5.
12. Brett BT, Smith SC, Bouvier CV, Michaeli D, Hochhauser D, Davidson BR, Kurzawinski TR, Watkinson AF, Van Someren N, Pounder RE, Caplin ME. Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer. J Clin Oncol 2002;20:4225-31.
13. Smith AM, Justin T, Michaeli D, Watson SA. Phase I/II study of G17-DT, an anti-gastrin immunogen, in advanced colorectal cancer. Clin Cancer Res 2000;6:4719-24.
14. Gilliam AD, Watson SA, Henwood M, McKenzie AJ, Humphreys JE, Elder J, Iftikhar SY, Welch N, Fielding J, Broome P, Michaeli D. A phase II study of G17DT in gastric carcinoma. Eur J Surg Oncol 2004;30:536-43.
15. Yu HG, Schrader H, Otte JM, Schmidt WE, Schmitz F. Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells. Biochem Pharmacol 2004;67:135-46.
16. Dubel S, Breitling F, Fuchs P, Zewe M, Gotter S, Welschof M, Moldenhauer G, Little M. Isolation of IgG antibody Fv-DNA from various mouse and rat hybridoma cell lines using the polymerase chain reaction with a simple set of primers. J Immunol Methods 1994;175:89-95.
17. Krebber A, Bornhauser S, Burmester J, Honegger A, Willuda J, Bosshard HR, Pluckthun A. Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system. J Immunol Methods 1997;201:35-55.
18. Barderas R, Shochat S, Martinez-Torrecuadrada J, Altschuh D, Meloen R, Casal JI. A fast mutagenesis procedure to recover soluble and functional scFvs containing amber stop codons from synthetic and semisynthetic antibody libraries. J Immunol Methods 2006;312:182-9.
19. Sui J, Li W, Murakami A, Tamin A, Matthews LJ, Wong SK, Moore MJ, Tallarico AS, Olurinde M, Choe H, Anderson LJ, Bellini WJ, et al. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human Mab to S1 protein that blocks receptor association. Proc Natl Acad Sci USA 2004;101:2536-41.
20. Goletz S, Christensen PA, Kristensen P, Blohm D, Tomlinson I, Winter G, Karsten U. Selection of large diversities of antiidiotypic antibody fragments by phage display. J Mol Biol 2002;315:1087-97.
21. Martinez-Torrecuadrada J, Cifuentes G, Lopez-Serra P, Saenz P, Martinez A, Casal JI. Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation. Clin Cancer Res 2005;11:6280-90.
22. Watson SA, Crosbee DM, Morris DL, Robertson JF, Makovec F, Rovati LC, Hardcastle JD. Therapeutic effect of the gastrin receptor antagonist. CR2093 on gastrointestinal tumour cell growth. Br J Cancer 1992;65:879-83.
23. Tracy HJ, Gregory RA. Physiological properties of a series of synthetic peptides structurally related to gastrin I. Nature 1964;204:935-8.
24. Szabo I, Rumi G, Bodis B, Nemeth P, Mozsik G. Gastrin and pentagastrin enhance the tumour proliferation of human stable cultured gastric adenocarcinoma cells. J Physiol (Paris) 2000;94:71-4.