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Nelson, M.1
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34249089383
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Kakuda, T.N.2
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Stone, J.3
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Lack of pharmacokinetic interaction between ritonavir-boosted GS-9137 (elvitegravir) and darunavir/r [abstract]
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Shen, G.2
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34347379935
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Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211
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Gulick RM, Su Z, Flexner C, et al. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-Infected, treatment-experienced patients: AIDS clinical trials group 5211. J Infect Dis 2007; 196:304-312. Greater viral load declines were observed in treatment-experienced patients receiving vicriviroc versus placebo plus optimized background therapy. Six patients receiving vicriviroc versus two receiving placebo developed malignancies during the study period.
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Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults
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This study demonstrated vicriviroc efficacy in 48 treatment-experienced patients after just 14 days of vicriviroc monotherapy
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Schurmann D, Fatkenheuer G, Reynes J, et al. Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults. AIDS 2007; 21:1293-1299. This study demonstrated vicriviroc efficacy in 48 treatment-experienced patients after just 14 days of vicriviroc monotherapy.
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Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial
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This study demonstrated the efficacy of etravirine in patients on failing antiretroviral therapy with evidence of resistance to currently available NNRTI and at least three primary protease inhibitor mutations
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Lazzarin A, Campbell T, Clotet B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007; 370:39-48. This study demonstrated the efficacy of etravirine in patients on failing antiretroviral therapy with evidence of resistance to currently available NNRTI and at least three primary protease inhibitor mutations.
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34347327010
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Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial
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This study demonstrated the efficacy of etravirine in patients on failing antiretroviral therapy with evidence of resistance to currently available NNRTI and at least three primary protease inhibitor mutations
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Madruga JV, Cahn P, Grinsztejn B, et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet 2007; 370:29-38. This study demonstrated the efficacy of etravirine in patients on failing antiretroviral therapy with evidence of resistance to currently available NNRTI and at least three primary protease inhibitor mutations.
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Scholler-Gyure M, Woodfall B, Bollen S, et al. Pharmacokinetics of amprenavir and TMC125 in HIV-infected volunteers receiving TMC125 with fosamprenavir/ritonavir [abstract]. In: 46th Interscience Conference on Antimicrobial Agents and Chemotherapy; 27-30 September 2006. San Francisco. Washington, DC: American Society of Microbiology; 2006. Abstract A0370.
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Drug interactions with TMC125, a potent next generation NNRTI [abstract]
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Baede P, Piscitelli S, Graham N, Van't Klooster G. Drug interactions with TMC125, a potent next generation NNRTI [abstract]. In: 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy; 27-30 September 2002; San Diego. Washington, DC: American Society of Microbiology; Abstract A1827.
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Graham, N.3
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34547780413
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Pharmacokinetics of darunavir/ritonavir and TMC125 alone and coadministered in HIV-negative volunteers
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Pharmacokinetics and antiretroviral response to darunavir/ritonavir and etravirine combination in patients with high-level viral resistance
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This small study was the first to evaluate the efficacy and pharmacokinetics of the combination of etravirine and darunavir/ritonavir in treatment-experienced patients
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Boffito M, Winston A, Jackson A, et al. Pharmacokinetics and antiretroviral response to darunavir/ritonavir and etravirine combination in patients with high-level viral resistance. AIDS 2007; 21:1449-1455. This small study was the first to evaluate the efficacy and pharmacokinetics of the combination of etravirine and darunavir/ritonavir in treatment-experienced patients.
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Pharmacokinetic evaluation of nonnucleoside reverse transcriptase inhibitor (NNRTI) TMC125 and integrase inhibitor (InSTI) raltegravir (RAL) in healthy subjects [abstract]
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22-25 July, Sydney. Geneva: IAS;, Abstract TuPdB02
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Anderson MS, Kakuda TN, Miller JL, et al. Pharmacokinetic evaluation of nonnucleoside reverse transcriptase inhibitor (NNRTI) TMC125 and integrase inhibitor (InSTI) raltegravir (RAL) in healthy subjects [abstract]. In: Fourth International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention; 22-25 July 2007; Sydney. Geneva: IAS; 2007. Abstract TuPdB02.
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TMC125 bioavailability is not affected by ranitidine and omeprazole [abstract]
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13-18 August, Toronto. Geneva: IAS;, Abstract TuPe0082
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Scholler-Gyure M, de Smedt G, Vanaken H, et al. TMC125 bioavailability is not affected by ranitidine and omeprazole [abstract]. In: XVI International AIDS Conference; 13-18 August 2006; Toronto. Geneva: IAS; 2006. Abstract TuPe0082.
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de Bethune MP, Andries K, Azijn H, et al. TMC278, a new potent NNRTI, with an increased barrier to resistance and favourable pharmacokinetic profile [abstract]. In: 12th Conference on Retroviruses and Opportunistic Infections; Boston. Alexandria: CROI; 2005; 22-25 February 2005. Abstract 556.
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