The presence of capsule in Cryptococcus neoformans influences the gene expression profile in dendritic cells during interaction with the fungus

Infection and Immunity

Volumn 76, Issue 4, 2008, Pages 1581-1589

  Lupo, P ^a,b   Chang, Y C ^a   Kelsall, B L ^a   Farber, J M ^a   Pietrella, D ^b   Vecchiarelli, A ^b   Leon, F ^a,c   Kwon Chung, K J ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF PERUGIA   (Italy)

^c MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; CHEMOKINE; CHEMOKINE RECEPTOR CCR7; CYTOKINE; DNA BINDING PROTEIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MEMBRANE PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 3; PROTEIN CCL22; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CYCLE; CELL INTERACTION; CELL MATURATION; CHEMOTAXIS; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CYTOKINE RELEASE; DENDRITIC CELL; ENCAPSULATION; FUNGAL STRAIN; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; UPREGULATION; ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CHEMOKINES; CRYPTOCOCCUS NEOFORMANS; DENDRITIC CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICE; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 42149120908     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01184-07     Document Type: Article

References (49)

1. Alexander, W. S. 2002. Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2:410-416.
2. Bacci, A., C. Montagnoli, K. Perruccio, S. Bozza, R. Gaziano, L. Pitzurra, A. Velardi, C. F. d'Ostiani, J. E. Cutler, and L. Romani. 2002. Dendritic cells pulsed with fungal RNA induce protective immunity to Candida albicans in hematopoietic transplantation. J. Immunol. 168:2904-2913.
3. Bulmer, G. S., and M. D. Sans. 1968. Cryptococcus neoformans. 3. Inhibition of phagocytosis. J. Bacteriol. 95:5-8.
4. Burkhardt, C., M. Muller, A. Badde, C. C. Garner, E. D. Gundelfinger, and A. W. Puschel. 2005. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett. 579:3821-3828.
5. Carrasco, D., R. P. Ryseck, and R. Bravo. 1993. Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells. Development 118:1221-1231.
6. Chang, Y. C., and K. J. Kwon-Chung. 1994. Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol. Cell. Biol. 14:4912-4919.
7. Cousens, L. P., J. S. Orange, H. C. Su, and C. A. Biron. 1997. Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94:634-639.
8. d'Ostiani, C. F., G. Del Sero, A. Bacci, C. Montagnoli, A. Spreca, A. Mencacci, P. Ricciardi-Castagnoli, and L. Romani. 2000. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans. Implications for initiation of T helper cell immunity in vitro and in vivo. J. Exp. Med. 191:1661-1674.
9. Engelhardt, B., and H. Wolburg. 2004. Transendothelial migration of leukocytes: through the front door or around the side of the house? Eur. J. Immunol. 34:2955-2963.
10. Fainaru, O., T. Shay, S. Hantisteanu, D. Goldenberg, E. Domany, and Y. Groner. 2007. TGFbeta-dependent gene expression profile during maturation of dendritic cells. Genes Immun. 8:239-244.
11. Feldmesser, M., and A. Casadevall. 1998. Mechanism of action of antibody to capsular polysaccharide in Cryptococcus neoformans infection. Front. Biosci. 3:d136-d151.
12. Feldmesser, M., A. Mednick, and A. Casadevall. 2002. Antibody-mediated protection in murine Cryptococcus neoformans infection is associated with pleotrophic effects on cytokine and leukocyte responses. Infect. Immun. 70:1571-1580.
13. Förster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23-33.
14. Geetha, T., and M. W. Wooten. 2002. Structure and functional properties of the ubiquitin binding protein p62. FEBS Lett. 512:19-24.
15. Gunn, M. D., S. Kyuwa, C. Tam, T. Kakiuchi, A. Matsuzawa, L. T. Williams, and H. Nakano. 1999. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189:451-160.
16. Havard, L., S. Rahmouni, J. Boniver, and P. Delvenne. 2005. High levels of p105 (NFKB1) and p100 (NFKB2) proteins in HPV16-transformed keratinocytes: role of E6 and E7 oncoproteins. Virology 331:357-366.
17. Herring, A. C., J. Lee, R. A. McDonald, G. B. Toews, and G. B. Huffnagle. 2002. Induction of interleukin-12 and gamma interferon requires tumor necrosis factor alpha for protective T1-cell-mediated immunity to pulmonary Cryptococcus neoformans infection. Infect. Immun. 70:2959-2964.
18. Jiang, W., W. J. Swiggard, C. Heufler, M. Peng, A. Mirza, R. M. Steinman, and M. C. Nussenzweig. 1995. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375:151-155.
19. Kawakami, K., X. Qifeng, M. Tohyama, M. H. Qureshi, and A. Saito. 1996. Contribution of tumour necrosis factor-alpha (TNF-alpha) in host defence mechanism against Cryptococcus neoformans. Clin. Exp. Immunol. 106:468- 474.
20. Kelly, R. M., J. Chen, L. E. Yauch, and S. M. Levitz. 2005. Opsonic requirements for dendritic cell-mediated responses to Cryptococcus neoformans. Infect. Immun. 73:592-598.
21. Kwon-Chung, K. J., and J. C. Rhodes. 1986. Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect. Immun. 51:218-223.
22. Lappin, M. B., J. M. Weiss, V. Delattre, B. Mai, H. Dittmar, C. Maier, K. Manke, S. Grabbe, S. Martin, and J. C. Simon. 1999. Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection. Immunology 98:181-188.
23. Larsen, C. P., S. C. Ritchie, T. C. Pearson, P. S. Linsley, and R. P. Lowry. 1992. Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations. J. Exp. Med. 176:1215-1220.
24. Levitz, S. M., A. Tabuni, T. R. Kozel, R. S. MacGill, R. R. Ingalls, and D. T. Golenbock. 1997. Binding of Cryptococcus neoformans to heterologously expressed human complement receptors. Infect. Immun. 65:931-935.
25. Li, C., A. J. Lusis, R. Sparkes, A. Nirula, and R. Gaynor. 1992. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF. Genomics 13:665-671.
26. Lyck, R., Y. Reiss, N. Gerwin, J. Greenwood, P. Adamson, and B. Engelhardt 2003. T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: the cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Blood 102:3675-3683.
27. Lyons, R. M., and H. L. Moses. 1990. Transforming growth factors and the regulation of cell proliferation. Eur. J. Biochem. 187:467-473.
28. Martin, E., B. O'Sullivan, P. Low, and R. Thomas. 2003. Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity 18:155-167.
29. McLaughlin, F., B. P. Hayes, C. M. Horgan, J. E. Beesley, C. J. Campbell, and A. M. Randi. 1998. Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta down-regulate intercellular adhesion molecule (ICAM)-2 expression on the endothelium. Cell Adhes. Commun. 6:381-400.
30. Mestas, J., and C. C. Hughes. 2004. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172:2731- 2738.
31. Mogensen, T. H., S. R. Paludan, M. Kilian, and L. Ostergaard. 2006. Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningiti dis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns. J. Leukoc. Biol. 80:267-277.
32. Nguyen, K. B., L. P. Cousens, L. A. Doughty, G. C. Pien, J. E. Durbin, and C. A. Biron. 2000. Interferon alpha/beta-mediated inhibition and promotion of interferon gamma: STAT1 resolves a paradox. Nat. Immunol. 1:70-76.
33. Perfect, J. R., B. Wong, Y. C. Chang, K. J. Kwon-Chung, and P. R. Williamson. 1998. Cryptococcus neoformans: virulence and host defences. Med. Mycol. 36(Suppl. 1):79-86.
34. Pons, J., J. Sauleda, V. Regueiro, C. Santos, M. Lopez, J. Ferrer, A. G. Agusti, and J. A. Bengoechea. 2006. Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease. Respir. Res. 7:64.
35. Rao, G. S., M. V. Ramachandran, and J. S. Bajaj. 2006. In silico structure-based design of a potent and selective small peptide inhibitor of protein tyrosine phosphatase 1B, a novel therapeutic target for obesity and type 2 diabetes mellitus: a computer modeling approach. J. Biomol. Struct. Dyn. 23:377-384.
36. Rovere, P., A. A. Manfredi, C. Vallinoto, V. S. Zimmermann, U. Fascio, G. Balestrieri, P. Ricciardi-Castagnoli, C. Rugarli, A. Tincani, and M. G. Sabbadini. 1998. Dendritic cells preferentially internalize apoptotic cells opsonized by anti-beta2-glycoprotein I antibodies. J. Autoimmun. 11:403-411.
37. Schulz, O., A. D. Edwards, M. Schito, J. Aliberti, S. Manickasingham, A. Sher, and C. Reis e Sousa. 2000. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453-462.
38. Shoham, S., C. Huang, J. M. Chen, D. T. Golenbock, and S. M. Levitz. 2001. Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule. J. Immunol. 166:4620-4626.
39. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301-314.
40. Syme, R. M., J. C. Spurrell, E. K. Amankwah, F. H. Green, and C. H. Mody. 2002. Primary dendritic cells phagocytose Cryptococcus neoformans via mannose receptors and Fcγ receptor II for presentation to T lymphocytes. Infect. Immun. 70:5972-5981.
41. Tian, B., and A. R. Brasier. 2003. Identification of a nuclear factor kappa B-dependent gene network. Recent Prog. Horm. Res. 58:95-130.
42. Vecchiarelli, A. 2007. Fungal capsular polysaccharide and T-cell suppression: the hidden nature of poor immunogenicity. Crit. Rev. Immunol. 27:547-557.
43. Vecchiarelli, A. 2005. The cellular responses induced by the capsular polysaccharide of Cryptococcus neoformans differ depending on the presence or absence of specific protective antibodies. Curr. Mol. Med. 5:413-420.
44. Vecchiarelli, A., D. Pietrella, P. Lupo, F. Bistoni, D. C. McFadden, and A. Casadevall. 2003. The polysaccharide capsule of Cryptococcus neoformans interferes with human dendritic cell maturation and activation. J. Leukoc. Biol. 74:370-378.
45. Vecchiarelli, A., C. Retini, D. Pietrella, C. Monari, C. Tascini, T. Beccari, and T. R. Kozel. 1995. Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes. Infect. Immun. 63:2919-2923.
46. Weih, F., G. Warr, H. Yang, and R. Bravo. 1997. Multifocal defects in immune responses in RelB-deficient mice. J. Immunol. 158:5211-5218.
47. Wilson, J. W., M. J. Schurr, C. L. LeBlanc, R. Ramamurthy, K. L. Buchanan, and C. A. Nickerson. 2002. Mechanisms of bacterial pathogenicity. Postgrad. Med. J. 78:216-224.
48. Winzler, C., P. Rovere, M. Rescigno, F. Granucci, G. Penna, L. Adorini, V. S. Zimmermann, J. Davoust, and P. Ricciardi-Castagnoli. 1997. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 185:317-328.
49. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, and T. Masaki. 1988. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415.