A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection

Infection and Immunity

Volumn 76, Issue 4, 2008, Pages 1535-1546

  Hu, Yanmin ^a   Henderson, Brian ^b   Lund, Peter A ^c   Tormay, Peter ^a   Ahmed, M Tabish ^c   Gurcha, Sudagar S ^c   Besra, Gurdyal S ^c   Coates, Anthony R M ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; MEMBRANE LIPID; PROTEIN CPN 10; PROTEIN CPN 60.1; PROTEIN CPN 60.2; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG; CHAPERONIN; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL SURVIVAL; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FEMALE; GENE DELETION; GENE INACTIVATION; GRANULOMATOUS INFLAMMATION; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRESS; TEMPERATURE SENSITIVITY; ANIMAL; BAGG ALBINO MOUSE; CELL WALL; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; LUNG; LUNG TUBERCULOSIS; MACROPHAGE; METABOLISM; MICROBIOLOGY; MUTATION; PHYSIOLOGY;

ANIMALS; CELL WALL; CHAPERONIN 10; CHAPERONIN 60; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GROEL PROTEIN; GROES PROTEIN; INFLAMMATION; LUNG; MACROPHAGES; MEMBRANE LIPIDS; MICE; MICE, INBRED BALB C; MUTATION; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS, PULMONARY;

EID: 42149117075     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01078-07     Document Type: Article

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