Cellular immune response from chagasic patients to CRA or FRA recombinant antigens of Trypanosoma cruzi

Journal of Clinical Laboratory Analysis

Volumn 22, Issue 2, 2008, Pages 91-98

  Lorena, Virginia M B ^a   Verçosa, Alinne F A ^a   Machado, Raquel C A ^a   Moitinho Silva, Lucas ^a   Cavalcanti, Maria G A ^b   Silva, Edimilson D ^c   Ferreira, Antonio G P ^c   Correa Oliveira, Rodrigo ^a   Pereira, Valeria R A ^a   Gomes, Yara M ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Instituto de Technologia em Imunobiologicos   (Brazil)

Author keywords

Chagas' disease; Cytokines; Recombinant antigens

Indexed keywords

CYTOPLASMIC REPETITIVE ANTIGEN; FLAGELLAR REPETITIVE ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; PARASITE ANTIGEN; PHYTOHEMAGGLUTININ; RECOMBINANT ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELLULAR IMMUNITY; CHAGAS DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE COURSE; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROGNOSIS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 42149090611     PISSN: 08878013     EISSN: 10982825     Source Type: Journal    
DOI: 10.1002/jcla.20209     Document Type: Article

References (52)

1. World Health Organization. Control of Chagas disease. WHO Technical Report Series 2002;905:109.
2. Dias JC, Silveira AC, Schofield CJ. The impact of Chagas' disease control in Latin America: a review. Mem Inst Oswaldo Cruz 2002;97:603-612.
3. Brener Z, Gazzinelli RT. Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int Arch Allergy Immunol 1997;114:103-110.
4. Kierszenbaum F. Views on the autoimmunity hypothesis for Chagas disease pathogenesis. FEMS Immunol Med Microbiol 2003;37:1-11.
5. Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D. Organ-specific disease provoked by systemic autoimmunity. Cell 1996;87:811-822.
6. Higuchi ML. Human chronic chagasic cardiopathy: participation of parasite antigens, subsets of lymphocytes, cytokines, and microvascular abnormalities. Mem Inst Oswaldo Cruz 1999;94:263-267.
7. Dutra WO, Martins-Filho OA, Cancado JR, et al. Activated T and B lymphocytes in peripheral blood of patients with Chagas' disease. Int Immunol 1994;6:499-506.
8. Corrêa-Oliveira R, Gomes JAS, Lemos EM, et al. The role of the immune response on the development of severe clinical forms of human Chagas disease. Mem Inst Oswaldo Cruz 1999;94:253-255.
9. Gomes JAS, Bahia-Oliveira LMG, Rocha MOC, Martins-Filho OA, Gazzinelli G, Corrêa-Oliveira R. Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune response. Infect Immun 2003;71:31185-31193.
10. Barros-Mazon S, Guariento ME, Silva C, Coffman RL, Abrahamsohn IA. Differential regulation of lymphoproliferative responses to Trypanosoma cruzi antigen in patients with the cardiac or indeterminate form of Chagas disease. Clin Immunol 2004;111:137-145.
11. Gomes JAS, Bahia-Oliveira LMG, Rocha MOC, et al. Type 1 chemokine receptor expression in Chagas' disease correlates with morbidity in cardiac patients. Infect Immun 2005;73:7960-7966.
12. Cardoso GM, Morato MJ, Gomes JA, et al. Comparative analysis of cell phenotypes in different severe clinical forms of Chagas' disease. Front Biosci 2006;11:1158-1163.
13. Cetron MS, Basilio FP, Moraes AP, et al. Humoral and cellular immune response of adults from Northeastern Brazil with chronic Trypanosoma cruzi infection: depressed cellular immune response to T. cruzi antigen among Chagas' disease patients with symptomatic versus indeterminate infection. Am J Trop Med Hyg 1993;49:370-382.
14. Mosca W, Plaja J, Hubsch R, Celillos R. Longitudinal study of immune response in human Chagas' disease. J Clin Microbiol 1985;22:438-441.
15. De Titto EH, Braun M, Lazzari JO, Segura EL. Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients. Immunol Lett 1985;9:249-254.
16. Morato MJ, Brener Z, Cançado JR, Nunes RM, Chiari E, Gazzinelli G. Cellular immune responses of chagasic patients to antigens derived from different Trypanosoma cruzi strains and clones. Am J Trop Med Hyg 1986;35:505-511.
17. Gazzinelli RT, Lerne VMC, Cançado R, Gazzinelli G, Scharfstein J. Identification and partial characterization of Trypanosoma cruzi antigens recognized by T cells and immune sera from patients with Chagas' disease. Infect Immun 1990;58:1437-1444.
18. Michailowsky V, Luhrs K, Rocha MOC, Fouts D, Gazzinelli RT, Manning JE. Humoral and cellular immune responses to Trypanosoma cruzi-derived paraflagellar rod proteins in patients with Chagas' disease. Infect Immun 2003;71:3165-3171.
19. Bahia-Oliveira LMG, Gomes JAS, Rocha MOC, et al. IFN-γ in human Chagas' disease: protection or pathology? Braz J Med Biol Res 1998;31:127-131.
20. Ribeirão M, Pereira-Chioccola VL, Nia L, Augusto Fragata FA, Schenkman S, Rodrigues MM. Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase. Parasite Immunol 2000;22:49-55.
21. Abel LCJ, Rizzo LV, Ianni B, et al. Chronic Chagas' disease cardiomyopathy patients display an increased IFN-γ response to Trypanosoma cruzi infection. J Autoimmun 2001;17:99-108.
22. Cuna WR, Encina JLR, Cuna CR. Interferon-γ or IL-10 production is induced by related Trypanosoma cruzi antigens. J Parasitol 2000;86:295-299.
23. Arnholdt AC, Piuvezam MR, Russo DM, et al. Analysis and partial epitope mapping of human T cell responses to Trypanosoma cruzi cysteinyl proteinase. J Immunol 1993;151:3171-3179.
24. Lorca M, Gonzalez A, Veloso C, Reyes V, Vergara U. Immunodetection of antibodies in sera from symptomatic and asymptomatic Chilean Chagas' disease patients with Trypanosoma cruzi recombinant antigens. Am J Trop Med Hyg 1992;46:44-49.
25. Motran CC, Serra HM, Gea SE, Vullo C, Vottero-Cima E. Antibody isotypes profiles against Trypanosoma cruzi antigens in two Ameridian populations from Chagas' disease endemic area. Acta Trop 1994;58:105-114.
26. Pereira VRA, Lorena VMB, Nakazawa M, et al. Evaluation of the immune response to CRA and FRA recombinant antigens of Trypanosoma cruzi in C57B1/6 mice. Rev Soc Bras Med Trop 2003a;36:435-440.
27. Pereira VRA, Lorena VMB, Verçosa AFA, et al. Antibody isotype responses in BALB/c mice immunized with the cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi. Mem Inst Oswaldo Cruz 2003b;98:823-825.
28. Pereira VRA, Lorena VMB, Galvão da Silva AP, et al. Immunization with cytoplasmic repetitive antigen and flagellar repetitive antigen of Trypanosoma cruzi stimulates a cellular immune response in mice. Parasitology 2004;129:563-570.
29. Pereira VRA, Lorena VMB, Nakazawa M, et al. Humoral and cellular immune responses in BALB/c and C57BL/6 mice immunized with cytoplasmic (CRA) and flagellar (FRA) recombinant repetitive antigens, in acute experimental Trypanosoma cruzi infection. Parasitol Res 2005;96:154-161.
30. Goldenberg S, Krieger MA, Lafaille JJ, Almeida E, Oelemann W. Use of Trypanosoma cruzi antigens in the immunological diagnosis of Chagas' disease. Mem Inst Butantan 1991;53:71-76.
31. Krigger MA, Almeida E, Oelemann W, et al. Use of recombinant antigens for the accurate immunodiagnosis of Chagas' disease. Am J Trop Med Hyg 1992;46:427-134.
32. Gomes YM, Pereira VRA, Nakazawa M, et al. Serodiagnosis of chronic Chagas' disease by using EIE-Recombinante-Chagas-Biomanguinhos kit. Mem Inst Oswaldo Cruz 2001;96:497-501.
33. Gadelha AAM, Verçosa AFA, Lorena VMB, et al. Chagas's disease diagnostics: comparative analysis of recombinant ELISA with conventional ELISA and hemagglutination test. Vox Sang 2003;85:165-170.
34. Silva ED, Pereira VRA, Gomes JAS, et al. Use of EIE-Recombinant-Chagas- Biomanguinhos kit to monitor cure of human Chagas' disease. J Clin Lab Anal 2002;16:132-136.
35. Verçosa AFA. Caracterização do perfil isotípico das imunoglobulinas G de individuos chagásicos anti os antígenos recombinantes CRA e FRA de Trypanosoma cruzi. Rev Pat Trop 2006;35:178.
36. Pereira VRA, Nakazawa M, Furtado C, Abath FGC, Gomes YM. Immunodiagnosis of chronic Chagasic disease using Tc 46 and Tc 58 antigens. Rev Soc Bras Med Trop 2000;33:367-370.
37. Dutra WO, Rocha MOC, Teixeira MM. The clinical immunology of human Chagas disease. Trends Parasitol 2005;21:12581-12587.
38. Schleifer KW, Mansfield JM. Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J Immunol 1993;151:5492-5503.
39. De Wall Malefyt R, Yssel H, Vries JE. Direct effects of IL-10 on subsets of human CD4+ T cells clones and resting T cells. Specific inhibition of IL-2 production and proliferation. J Immunol 1993;150:4754-4765.
40. Pinge-Filho P, Tadokoro CE, Abrahamsohn IA. Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection. Cell Immunol 1999;193:90-98.
41. Cunha-Neto E, Rizzo LV, Albuquerque F, et al. Cytokine production profile of heart-infiltrating T cells in Chagas' disease cardiomyopathy. Braz J Med Biol Res 1998;31:133-137.
42. Reis DD, Jones EM, Tostes S, et al. Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of TNF-α+ cells and dominance of granzyme A+, CD8+ lymphocytes. Am J Trop Med Hyg 1993;48:637-642.
43. Reis MM, Higuchi ML, Banvenuti LA, et al. An in situ quantitative immunohistochemical study of cytokines and IL-2R + in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clin Immunol Immunopathol 1997;83:165-172.
44. Dutra WO, Gollob KJ, Pinto-Dias JC, et al. Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi infection. Scand J Immunol 1997;45:74-80.
45. Bachmaier K, Neu N, Pummerer C, et al. INOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1. Circulation 1997;96:585-591.
46. Silva JS, Morrissey PJ, Grabstein KH, Mohler KM, Anderson D, Reed SG. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. J Exp Med 1992;175:169-174.
47. Maloy KJ, Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2001;2:816-822.
48. Trzonskowski P, Szmit E, Mysliwska J, Dobyszuk A, Mysliwska A. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction. Clin Immunol 2004;112:258-267.
49. Samudio M, Montenegro-James S, Cabral M, et al. Differential expression of systemic cytokine profiles in Chagas' disease is associated with endemicity of Trypanosoma cruzi infections. Acta Trop 1998;69:89-97.
50. Laucella SA, Postan M, Martin D, et al. Frequency of interferon-γ- producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease. J Infect Dis 2004;189:909-918.
51. Baroja ML, Ceuppens JL. More exact quantification of interleuk-2 production by addition of anti-Tac monoclonal antibody to cultures of stimulated lymphocytes. J Immunol Methods 1987;98:267-270.
52. Prussin C, Metcalfe DD. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Methods 1995;188:117-128.