Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases β and λ from Talaromyces sp.

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 8, 2008, Pages 4594-4599

  Kimura, Takuma ^a   Nishida, Masayuki ^b   Kuramochi, Kouji ^a   Sugawara, Fumio ^a   Yoshida, Hiromi ^b   Mizushina, Yoshiyuki ^b  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Azaphilone; DNA polymerase ; DNA polymerase ; Enzyme inhibitor; Family X of DNA polymerases; Kasanosin A; Kasanosin B

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA POLYMERASE LAMBDA; KASANOSIN A; KASANOSIN B; NUCLEOTIDYLTRANSFERASE; NUCLEOTIDYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG INHIBITION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; EUKARYOTIC CELL; HUMAN; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS; TALAROMYCES;

ANIMALS; BENZOPYRANS; DNA POLYMERASE BETA; HUMANS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PIGMENTS, BIOLOGICAL; TALAROMYCES;

BOVINAE; EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS 1; PROKARYOTA; RATTUS; TALAROMYCES;

EID: 42149089140     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.02.037     Document Type: Article

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