Design and synthesis of new 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1, 3,4-oxadiazoles as anticonvulsant agents

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 4, 2008, Pages 509-512

  Zarghi, Afshin ^a   Hajimahdi, Zahra ^a   Mohebbi, Shohreh ^a   Rashidi, Hootesa ^a   Mozaffari, Sasan ^a   Sarraf, Sahar ^a   Faizi, Mehrdad ^a   Tabatabaee, Seyed Abbas ^a   Shafiee, Abbas ^b  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1,3,4 oxadiazole; Anticonvulsant; Benzodiazepine receptor; Structure activity relationship (SAR)

Indexed keywords

2 AMINO 5 (2 HALO 2 BENZYLOXYPHENYL) 1,3,4 OXADIAZOLE DERIVATIVE; 2 HALO 2 BENZYLOXYBENZOIC ACID HYDRAZIDE; 5 (2 HALO 2 BENZYLOXYPHENYL) 1,3,4 OXADIAZOLE DERIVATIVE; 5 [2 (2 HALOBENZYLOXY)PHENYL] 1,3,4 OXADIAZOLE DERIVATIVE; AMINE; ANTICONVULSIVE AGENT; BENZODIAZEPINE RECEPTOR; DIAZEPAM; FUNCTIONAL GROUP; OXADIAZOLE DERIVATIVE; PENTETRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CONVULSION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MALE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CHEMISTRY, PHYSICAL; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ELECTROSHOCK; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; OXADIAZOLES; PENTYLENETETRAZOLE; RECEPTORS, GABA-A; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 42049107504     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.509     Document Type: Article

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