Recovery of humoral immunity is critical for successful antiviral therapy in disseminated mouse adenovirus type 1 infection

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 4, 2008, Pages 1462-1471

  Lenaerts, L ^a   Kelchtermans, H ^a   Geboes, L ^a   Matthys, P ^a   Verbeken, E ^b   De Clercq, E ^a   Naesens, L ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CIDOFOVIR; CYCLOPHOSPHAMIDE; IMMUNOGLOBULIN G; MOUSE ADENOVIRUS TYPE 1 ANTIBODY; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; ENTERITIS; FEMALE; HUMORAL IMMUNE DEFICIENCY; HUMORAL IMMUNITY; INFECTION RISK; INTESTINAL BLEEDING; LEUKOPENIA; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MORTALITY; MOUSE; MOUSE ADENOVIRUS TYPE 1; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SURVIVAL RATE; T LYMPHOCYTE; TREATMENT OUTCOME; VIRUS INFECTION;

3T3 CELLS; ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANIMALS; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; CELL LINE; CYCLOPHOSPHAMIDE; CYTOSINE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, SCID; PHOSPHONIC ACIDS; TREATMENT OUTCOME;

EID: 42049102794     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01311-07     Document Type: Article

References (40)

1. Alinari, L., R. Lapalombella, L. Andritsos, R. A. Baiocchi, T. S. Lin, and J. C. Byrd. 2007. Alemtuzumab (Campath-1H) in the treatment of chronic lymphocytic leukemia. Oncogene 26:3644-3653.
2. + cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice. Blood 95:212-220.
3. Avivi, I., S. Chakrabarti, D. W. Milligan, H. Waldmann, G. Hale, H. Osman, K. N. Ward, C. D. Fegan, K. Yong, A. H. Goldstone, D. C. Linch, and S. Mackinnon. 2004. Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab. Biol. Blood Marrow Transplant. 10:186-194.
4. Bordigoni, P., A. S. Carret, V. Venard, F. Witz, and A. Le Faou. 2001. Treatment of adenovirus infections in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin. Infect. Dis. 32:1290-1297.
5. Cao, L., A. Martin, N. Polakos, and J. A. Moynihan. 2004. Stress causes a further decrease in immunity to herpes simplex virus-1 in immunocompromised hosts. J. Neuroimmunol. 156:21-30.
6. Chakrabarti, S., K. E. Collingham, C. D. Fegan, D. Pillay, and D. W. Milligan. 2000. Adenovirus infections following haematopoietic cell transplantation: is there a role for adoptive immunotherapy? Bone Marrow Transplant. 26:305-307.
7. Chakrabarti, S., V. Mautner, H. Osman, K. E. Collingham, C. D. Fegan, P. E. Klapper, P. A. Moss, and D. W. Milligan. 2002. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood 100:1619-1627.
8. Charles, P. C., J. D. Guida, C. F. Brosnan, and M. S. Horwitz. 1998. Mouse adenovirus type-1 replication is restricted to vascular endothelium in the CNS of susceptible strains of mice. Virology 245:216-228.
9. Crooks, B. N., C. E. Taylor, A. J. Turner, H. K. Osman, M. Abinun, T. J. Flood, and A. J. Cant. 2000. Respiratory viral infections in primary immune deficiencies: significance and relevance to clinical outcome in a single BMT unit. Bone Marrow Transplant. 26:1097-1102.
10. Dagan, R., R. H. Schwartz, R. A. Insel, and M. A. Menegus. 1984. Severe diffuse adenovirus 7a pneumonia in a child with combined immunodeficiency: possible therapeutic effect of human immune serum globulin containing specific neutralizing antibody. Pediatr. Infect. Dis. 3:246-251.
11. Emovon, O. E., A. Lin, D. N. Howell, F. Afzal, M. Baillie, J. Rogers, P. K. Baliga, K. Chavin, V. Nickeleit, P. R. Rajagapalan, and S. Self. 2003. Refractory adenovirus infection after simultaneous kidney-pancreas transplantation: successful treatment with intravenous ribavirin and pooled human intravenous immunoglobulin. Nephrol. Dial. Transplant. 18:2436-2438.
12. Feuchtinger, T., P. Lang, and R. Handgretinger. 2007. Adenovirus infection after allogeneic stem cell transplantation. Leuk. Lymphoma 48:244-255.
13. Gavin, P. J., and B. Z. Katz. 2002. Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children. Pediatrics 110:e9.
14. Guida, J. D., G. Fejer, L. A. Pirofski, C. F. Brosnan, and M. S. Horwitz. 1995. Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice. J. Virol. 69:7674-7681.
15. Hartline, C. B., K. M. Gustin, W. B. Wan, S. L. Ciesla, J. R. Beadle, K. Y. Hostetler, and E. R. Kern. 2005. Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro. J. Infect. Dis. 191:396-399.
16. Heemskerk, B., A. C. Lankester, T. van Vreeswijk, M. F. Beersma, E. C. Claas, L. A. Veltrop-Duits, A. C. Kroes, J. M. Vossen, M. W. Schilham, and M. J. van Tol. 2005. Immune reconstitution and clearance of human adenovirus viremia in pediatric stem-cell recipients. J. Infect. Dis. 191:520-530.
17. Hoffman, J. A., A. J. Shah, L. A. Ross, and N. Kapoor. 2001. Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol. Blood Marrow Transplant. 7:388-394.
18. Howard, D. S., G. L. Phillips II, D. E. Reece, R. K. Munn, J. Henslee-Downey, M. Pittard, M. Barker, and C. Pomeroy. 1999. Adenovirus infections in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 29:1494-1501.
19. Hromas, R., K. Cornetta, E. Srour, C. Blanke, and E. R. Broun. 1994. Donor leukocyte infusion as therapy of life-threatening adenoviral infections after T-cell-depleted bone marrow transplantation. Blood 84:1689-1690.
20. Iyengar, S. R., B. G. Blackburn, and D. B. Lewis. 2007. Severe hypogamma-globulinemia and absent B cells in an adult patient: a case report. J. Allergy Clin. Immunol. 119:S256-.
21. Iyer, A., R. Mathur, B. V. Deepak, and J. Sinard. 2006. Fatal adenoviral hepatitis after rituximab therapy. Arch. Pathol. Lab. Med. 130:1557-1560.
22. Kojaoghlanian, T., P. Flomenberg, and M. S. Horwitz. 2003. The impact of adenovirus infection on the immunocompromised host. Rev. Med. Virol. 13:155-171.
23. Lankester, A C., B. Heemskerk, E. C. Claas, M. W. Schilham, M. F. Beersma, R. G. Bredius, M. J. van Tol, and A. C. Kroes. 2004. Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection. Clin. Infect. Dis. 38:1521-1525.
24. Legrand, F., D. Berrebi, N. Houhou, F. Freymuth, A. Faye, M. Duval, J. F. Mougenot, M. Peuchmaur, and E. Vilmer. 2001. Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children. Bone Marrow Transplant. 27:621-626.
25. Lenaerts, L., D. Daelemans, N. Geukens, E. De Clercq, and L. Naesens. 2006. Mouse adenovirus type 1 attachment is not mediated by the Coxsackie-adenovirus receptor. FEBS Lett. 580:3937-3942.
26. Lenaerts, L., and L. Naesens. 2006. Antiviral therapy for adenovirus infections. Antivir. Res. 71:172-180.
27. Lenaerts, L., E. Verbeken, E. De Clercq, and L. Naesens. 2005. Mouse adenovirus type 1 infection in SCID mice: an experimental model for antiviral therapy of systemic adenovirus infections. Antimicrob. Agents Chemother. 49:4689-4699.
28. Leo, O., M. Foo, D. H. Sachs, L. E. Samelson, and J. A. Bluestone. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84:1374-1378.
29. Liekens, S., J. Neyts, E. De Clercq, E. Verbeken, D. Ribatti, and M. Presta. 2001. Inhibition of fibroblast growth factor-2-induced vascular tumor formation by the acyclic nucleoside phosphonate cidofovir. Cancer Res. 61:5057-5064.
30. Lucas, K. G., Q. Sun, R. L. Burton, A. Tilden, W. P. Vaughan, M. Carabasi, D. Salzman, and A. Ship. 2000. A phase I-II trial to examine the toxicity of CMV- and EBV-specific cytotoxic T lymphocytes when used for prophylaxis against EBV and CMV disease in recipients of CD34-selected/T cell-depleted stem cell transplants. Hum. Gene Ther. 11:1453-1463.
31. Moore, M. L., C. C. Brown, and K. R. Spindler. 2003. T cells cause acute immunopathology and are required for long-term survival in mouse adenovirus type 1-induced encephalomyelitis. J. Virol. 77:10060-10070.
32. Moore, M. L., E. L. McKissic, C. C. Brown, J. E. Wilkinson, and K. R. Spindler. 2004. Fatal disseminated mouse adenovirus type 1 infection in mice lacking B cells or Bruton's tyrosine kinase. J. Virol. 78:5584-5590.
33. Myers, G. D., R. A. Krance, H. Weiss, I. Kuehnle, G. Demmler, H. E. Heslop, and C. M. Bollard. 2005. Adenovirus infection rates in pediatric recipients of alternate donor allogeneic bone marrow transplants receiving either antithymocyte globulin (ATG) or alemtuzumab (Campath). Bone Marrow Transplant. 36:1001-1008.
34. Pirofski, L., M. S. Horwitz, M. D. Scharff, and S. M. Factor. 1991. Murine adenovirus infection of SCID mice induces hepatic lesions that resemble human Reye syndrome. Proc. Natl. Acad. Sci. USA 88:4358-4362.
35. Siegal, F. P., S. H. Dikman, R. B. Arayata, and E. J. Bottone. 1981. Fatal disseminated adenovirus 11 pneumonia in an agammaglobulinemic patient. Am. J. Med. 71:1062-1067.
36. Smee, D. F., K. W. Bailey, M. H. Wong, M. K. Wandersee, and R. W. Sidwell. 2004. Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice. J. Infect. Dis. 190:1132-1139.
37. Smee, D. F., R. A. Burger, J. Coombs, J. H. Huffman, and R. W. Sidwell. 1991. Progressive murine cytomegalovirus disease after termination of ganciclovir therapy in mice immunosuppressed by cyclophosphamide treatment. J. Infect. Dis. 164:958-961.
38. Smith, K., C. C. Brown, and K. R. Spindler. 1998. The role of mouse adenovirus type 1 early region 1A in acute and persistent infections in mice. J. Virol. 72:5699-5706.
39. van Tol, M. J., A. C. Kroes, J. Schinkel, W. Dinkelaar, E. C. Claas, C. M. Jol-van der Zijde, and J. M. Vossen. 2005. Adenovirus infection in paediatric stem cell transplant recipients: increased risk in young children with a delayed immune recovery. Bone Marrow Transplant. 36:39-50.
40. Vieira, P., and K. Rajewsky. 1988. The half-lives of serum immunoglobulins in adult mice. Eur. J. Immunol. 18:313-316.