New insights into the importance of aminopeptidase A in hypertension

Heart Failure Reviews

Volumn 13, Issue 3, 2008, Pages 273-284

  Mizutani, Shigehiko ^a   Ishii, Masakazu ^b   Hattori, Akira ^b   Nomura, Seiji ^a   Numaguchi, Yasushi ^a   Tsujimoto, Masafumi ^b   Kobayshi, Hiroshi ^c   Murohara, Toyoaki ^a   Wright, John W ^d  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Aminopeptidase A; Angiotensin II; Hormone replacement therapy; Hypertensive rats; Preeclampsia

Indexed keywords

1 (4 AMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDROIMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 2 ETHYL 5,7 DIMETHYL 3 [4 [2 (2H TETRAZOL 5 YL)PHENYL]BENZYL]IMIDAZO[4,5 B]PYRIDINE; 3 AMINO 4 THIOBUTYLSULFONATE; 4 PENTAFLUOROETHYL 2 PROPYL 1 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1 (4 METHOXY 3 METHYLBENZYL) 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; 5 METHYL 7 PROPYL 8 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDIN 2(3H) ONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; BACULOVIRUS VECTOR; CANDESARTAN; CGP 46027; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EC 33; EPROSARTAN; GLUTAMYL AMINOPEPTIDASE; LOSARTAN; LOSARTAN POTASSIUM; MICROSOMAL AMINOPEPTIDASE; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; PD 124125; PD124125; PEPTIDE; SARALASIN; SC 51316; UNCLASSIFIED DRUG; ZOLASARTAN;

ARTICLE; BLOOD PRESSURE REGULATION; DAHL SALT SENSITIVE RAT; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; HEART FAILURE; HORMONE SUBSTITUTION; HUMAN; HYPERTENSION; LOW DRUG DOSE; NONHUMAN; PREECLAMPSIA; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENOVASCULAR HYPERTENSION; SPONTANEOUSLY HYPERTENSIVE RAT; VIRAL GENE DELIVERY SYSTEM;

ANGIOTENSIN II; ANIMALS; ANTIHYPERTENSIVE AGENTS; FEMALE; GLUTAMYL AMINOPEPTIDASE; HUMANS; HYPERTENSION; PRE-ECLAMPSIA; PREGNANCY; RENIN-ANGIOTENSIN SYSTEM;

EID: 42049090662     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-007-9065-7     Document Type: Article

References (74)

1. Mangos GJ (2006) Cardiovascular disease following pre-eclampsia: understanding the mechanisms. J Hyperten 24:639-641
2. Basile JN, Chrysant S (2006) The importance of early antihypertensive efficacy: The role of angiotensin therapy. J Hum Hyperten 20:169-175
3. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000) International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 52:415-472
4. Gard PR (2002) The role of angiotensin II in cognition and behaviour. Eur J Pharmacol 438:1-14
5. McKinley MJ, Albiston AL, Allen AM, Mathai ML, May CN, McAllen RM, Oldfield BJ, Mendelsohn FAO, Chai SY (2003) The brain renin-angiotensin system: Location and physiological roles. Int J Biochem Cell Biol 35:901-918
6. Thomas WG, Mendelsohn FAO (2003) Molecules in focus: Angiotensin receptors: Form and function and distribution. Int J Biochem Cell Biol 35:774-779
7. Wright JW, Harding JW (2004) The brain angiotensin system and extracellular matrix molecules in neural plasticity, learning, and memory. Prog Neurobiol 72:263-293
8. de Gasparo M, Siragy HM (1999) The AT 2 receptor: Fact, fancy and fantasy. Regul Pept 81:11-24
9. Speth RC, Thompson SM, Johns SJ (1995) Angiotensin II receptors: structural and functional considerations. In: Mukhopadhyay AK, Raizada MK (eds) Current concepts: Tissue renin angiotensin systems as local regulators in reproductive and endocrine organs. Plenum Press, New York, pp 169-192
10. Johnston CI (1990) Biochemistry and pharmacology of the renin-angiotensin system. Drugs 39:21-31
11. Chauvel EN, Llorens-Cortes C, Coric P, Wilk S, Roques BP, Fournie-Zaluski MC (1994) Differential inhibition of aminopeptidase A and aminopeptidase N by new-amino thiols. J Med Chem 37:2950-2957
12. Mizutani S, Akiyama H, Kurauchi O, Taira H, Narita O, Tomoda Y (1985) In vitro degradation of angiotensin II (A-II) by human placental subcellular fractions, pregnancy sera and purified placental aminopeptidases. Acta Endocrinol 110:35-139
13. Rich DH, Moon BJ, Harbeson S (1984) Inhibition of aminopeptidases by amastatin and bestatin derivatives, effect of inhibitor structure on slow-binding processes. J Med Chem 27:417-422
14. Wilk S, Healy DP (1993) Glutamyl aminopeptidase (aminopeptidase A), the BP-1/6C3 antigen. Adv Neuroimmunol 3:195-207
15. Wright JW, Harding JW (1997) Important roles for angiotensin III and IV in the brain renin-angiotensin system. Brain Res Rev 25:96-124
16. Sayeski PP, Ali MS, Semeniuk DJ, Doan TN, Bernstein KE (1998) Angiotensin II signal transduction pathways. Regul Pept 78:19-29
17. Guo DF, Inagami T (1994) The genomic organization of the rat angiotensin II receptor AT 1B. Biochim Biophys Acta 1218:91-94
18. Saavedra JM (1999) Emerging features of brain angiotensin receptors. Regul Pept 85:31-45
19. Phillips MI, Sumners C (1998) Angiotensin II in central nervous system physiology. Regul Pept 78:1-11
20. Wright JW, Harding JW (1992) Regulatory role of brain angiotensins in the control of physiological and behavioral responses. Brain Res Rev 17:227-262
21. 1 -receptor blockers. J Hum Hyper 16: S64-S70
22. Muratami H (1996) Brain angiotensin and circulatory control. Clin Exp Pharmacol Physiol 23:458-464
23. Phillips MI (1987) Functions of angiotensin in the central nervous system. Annu Rev Physiol 49:413-435
24. 1-receptors in the central nervous system. J Renin Angiotensin Aldosterone Syst 2(Suppl 1):S95-S101
25. Dampney RAL, Hirooka Y, Potts PD, Head GA (1996) Functions of angiotensin peptides in the rostral ventrolateral medulla. Clin Exp Pharmacol Physiol 3(Suppl):S105-S111
26. 1 receptors in the central control of sympathetic vasomotor function. Clin Exp Pharmacol Physiol 3(Suppl):S93-S98
27. Unger T, Becker H, Petty M, Demmert G, Schneider B, Ganten D, Lang RE (1985) Differential effects of central angiotensin II and substance P on sympathetic nerve activity in conscious rats. Implications for cardiovascular adaptation to behavioral responses. Circ Res 56:563-575
28. Zini S, Fournie-Zaluski MC, Chauvel E, Roques BP, Corvol P, Llorens-Cortes C (1996) Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: Predominant role of angiotensin III in the control of vasopressin release. Proc Natl Acad Sci USA 93:11968-11973
29. Song L, Wilk S, Healy DP (1997) Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses. Brain Res 744:1-6
30. Wright JW, Tamura-Myers E, Wilson WL, Roques BP, Llorens-Cortes C, Speth RC, Harding JW (2002) Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats. Am J Physiol Regul Integr Comp Physiol 284:R725-R733
31. Inguimbert N, Coric P, Dhotel H, Bonnard E, LLorens-Cortes C, Mota N, Fournie-Zaluski MC, Roques BP (2005) Synthesis and in vitro activities of new non-peptidic APA inhibitors. J Pept Res 65:175-188
32. Harding JW, Yoshida MS, Dilts RP, Woods TM, Wright JW (1986) Cerebroventricular and intravascular metabolism of 125 I-angiotensins in rat. J Neurochem 46:1292-1297
33. Bakris GL, Williams M, Dworkin L, Elliott WJ, Epstein M, Toto R (2000) Preserving renal function in adults with hypertension and diabetes: A consensus approach. Am J Kidney Dis 36:646-661
34. Long DA, Price KL, Herrera-Acosta J, Johnson RJ (2004) How does angiotensin II cause renal injury? Hypertension 43:722-723
35. Cooper ME (2001) Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 44:1957-1972
36. Karalliedde J, Viberti G (2006) Evidence for renoprotection by blockage of the rennin-angiotensin-aldosterone system in hypertension and diabetes. J Hum Hyperten 20:239-253
37. Yamada R, Mizutani S, Kurauchi O, Okano K, Imaizumi H, Narita O, Tomoda Y (1988) Purification and characterization of human placental aminopeptidase A. Enzyme 40:223-230
38. Healy DP, Song L (1999) Kidney aminopeptidase A and hypertension, part I spontaneously hypertensive rats. Hypertension 33:740-745
39. Raasch W, Johren O, Schwartz S, Gieselberg A, Dominiak P (2004) Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens 22:611-618
40. Mizutani S, Okano K, Hasegawa E, Sakura H, Oya M, Yamada M (1982) Human placental leucine aminopeptidase (P-LAP) as a hypotensive agent. Experientia 38:821-822
41. Mizutani S, Furuhashi M, Imaizumi H, Ito Y, Kurauchi O, Tomoda Y (1987) Effects of human placental aminopeptidases in spontaneously hypertensive rats. Med Sci Res 15:1203-1204
42. Wolf G, Menzel S, Assmann KJM (1997) Aminopeptidase A: A key enzyme in the intrarenal degradation of angiotensin II. Exp Nephrol 5:364-369
43. Nakashima Y, Ohno Y, Itakura A, Takeuchi M, Mutata Y, Kuno N, Mizutani S (2002) Possible involvement of aminopeptidase A in hypertension in spontaneously hypertensive rats (SHRs) and change of refractoriness in response to angiotensin II in pregnant SHRs. J Hypertens 20:2233-2238
44. Goto Y, Hattori A, Ishii Y, Mizutani S, Tsujimoto M (2006) Enzymatic properties of aminopeptidase A: Regulation of its enzymatic activity by calcium and angiotensin IV. J Biol Chem 281:23503-23513
45. Bivol LM, Vagnes OB, Iversen BM (2005) The renal vascular response to ANG II injection is reduced in the nonclipped kidney of two-kidney, one-clip hypertension. Am J Physiol Renal Physiol 289:F393-F400
46. Prieto I, Martinez JM, Hermoso F, Ramirez MJ, de Gasparo M, Vargas F, Alba F, Ramirez M (2001) Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats. Horm Metab Res 33:559-563
47. Prieto I, Hermoso F, Gaspara M, Vargas F, Alba F, Segarra AB, Banegas I, Ramirez M (2003) Angiotensinase activities in the kidney of renovascular hypertensive rats. Peptides 24:755-760
48. Wolf G, Wenzel U, Assmann KJM, Stahl RAK (2000) Renal expression of aminopeptidase A in rats with two-kidney, one-clip hypertension. Nephrol Dial Transplant 15:1935-1942
49. Wolf G, Thaiss F, Scherberich JE, Schoeppe W, Stahl RA (1990) Glomerular angiotensinase A in the rat: Increase of enzyme activity following renal ablation. Kidney Int 38:862-868
50. Hariyama Y, Itakura A, Okamura M, Ito M, Murata Y, Nagasaka T, Mizutani S (2002) Placental aminopeptidase A as a possible barrier of angiotensin II between mother and fetus. Placenta 21:621-627
51. Ino K, Uehara C, Kikkawa F, Kajiyama H, Shibata K, Suzuki T, Khin EE, Ito M, Takeuchi M, Itakura A, Mizutani S (2003) Enhancement of aminopeptidase A expression during angiotensin II-induced choriocharcinoma cell proliferation through AT1 receptor involving protein kinase C-and mitogen-activated protein kinase-dependent signaling pathway. J Clin Endocrinol Metab 88:3973-3982
52. Lin Q, Taniuchi I, Kitamura D, Wang J, Kearney JF, Watanabe T, Cooper MD (1998) T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J Immunol 160:4681-4687
53. Mitsui T, Nomura S, Okada M, Ohno Y, Kobayashi H, Nakashima Y, Murata Y, Takeuchi M, Kuno N, Nagasaka T, O-Wang J, Cooper MD, Mizutani S (2003) Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice. Mol Med 9:57-62
54. Lavoie JL, Bianco RA, Sakai K, Keen HL, Ryan MJ, Sigmund CD (2004) Transgenic mice for studies of the renin-angiotensin system in hypertension. Acta Physiol Scand 181:571-577
55. Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fogo A, Niimura F, Ichikawa I, Hogan BLM, Inagami T (1995) Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 377:748-750
56. Ouali R, Bethelon MC, Begeot M, Saez JM (1997) Angiotensin II receptor subtypes AT1 and AT2 are down-regulated by angiotensin II through AT1 receptor by different mechanisms. Endocrinology 138:725-733
57. Kagami S, Border WA, Miller DE, Noble NA (1994) Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 93:2431-2437
58. Kobori H, Nishiyama A, Abe Y, Navar G (2003) Enhancement of intrarenal angiotensinogen in Dahl salt-sensitive rats on high salt diet. Hypertension 41:592-597
59. Nomura M, Nomura S, Mitsui T, Suzuki M, Kobayashi H, Ito T, Itakura A, Kikkawa F, Mizutani S (2005) Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats. Am J Hypertens 18:538-543
60. Otsuka F, Yamauchi T, Kataoka H, Mimura Y, Ogura T, Makino H (1998) Effects of chronic inhibition of ACE and AT1 receptors on glomerular injury in Dahl salt-sensitive rats. Am J Physiol 274:R1797-R1806
61. Mizutani S, Tomoda Y (1996) Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia. Am J Hypertens 9:591-597
62. Broughton-Pipkin F, Symonds EM (1977) Factors affecting angiotensin II concentrations in the human infant at birth. Clin Sci Molec Med 52:449-456
63. Safwat MA, Mizutani S, Hosam ST, Sayed MA, Itakura A, Neveen HA, Kuno N, Kurauchi O, Tomoda Y (1995) Changes of placental proteases, which degrade vasoactive peptidases, in maternal sera at the onset of preeclampsia. Med Sci Res 23:123-126
64. Gant NF, Daley GL, Chand S, Whalley PJ, MacDonald PC (1973) A study of angiotensin II pressor responses throughout primigravid pregnancy. J Clin Invest 52:2682-2689
65. Saito T, Ishida J, Takimoto-Ohnishi E, Takamine S, Shimizu T, Sugaya T, Kato H, Matsuoka T, Nangaku M, Kon Y, Sugiyama F, Yagami K-I, Fukamizu A (2004) An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation. The FASEB J 18:388-390
66. Binder ND, Anderson DF (1992) Plasma renin activity responses to graded decreases in renal perfusion pressure in fetal and newborn lambs. Am J Physiol 262:R524-R529
67. Martinez JM, Prieto I, Ramirez MJ, de Gasparo M, Hermoso F, Arias JM, Alba F, Ramirez M (1998) Sex differences and age-related changes in human serum aminopeptidase A activity. Clin Chim Acta 274:53-61
68. Baylis C, Engels K, Hymel A, Navar LG (1997) Plasma renin activity and metabolic rate of angiotensin II in the unstressed aging rat. Mech Aging Dev 97:163-172
69. Ijima M, Nomura S, Okada M, Ikoma Y, Ito T, Mitsui T, Maeda O, Mizutani S (2002) Effects of age, hypertension and HRT on serum aminopeptidase A activity. Matutitas 43:215-221
70. Ferris JB, Sullivan PA, Gonggrijp H, Cole M, O'sullivan DJ (1982) Plasma angiotensin II and aldosterone in unselected diabetic patients. Cli Endocrinol 17:261-269
71. Duggan J, Kifeather S, O'Brien E, O'Mallery K, Nussberger J (1992) Effects of aging and hypertension on plasma angiotensin II and platelet angiotensin II receptor density. Am J Hypertens 5:687-693
72. Hinojosa-Laborde C, Craig T, Zheng W, Ji H, Haywood JR, Sandberg K (2004) Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension 44:405-409
73. Inoko M, Kihara Y, Moii I, Fujiwara H, Sasayama S (1994) Transition from compensatory hypertrophy to dilated, failing left ventricles in Dahl salt-sensitive rats. Am J Physiol 267:H2471-H2482
74. Vaughan CJ, Delanty N (2000) Hypertensive emergencies. Lancet 356:411-417