Aminopeptidase A: A key enzyme in the intrarenal degradation of angiotensin ii

Experimental Nephrology

Volumn 5, Issue 5, 1997, Pages 364-369

  Wolf, Gunter ^a,c   Mentzel, Stef ^b   Assmann, Karel J M ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Aminopeptidase A; Angiotensins; Glomerulonephritis; Organ distribution; Renin angiotensin system

Indexed keywords

ANGIOTENSIN; GLUTAMYL AMINOPEPTIDASE;

ENZYME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY BLOOD FLOW; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RECEPTOR BINDING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHORT SURVEY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANGIOTENSIN II; ANIMALS; GLUTAMYL AMINOPEPTIDASE; HUMANS; KIDNEY; KIDNEY DISEASES; MOLECULAR SEQUENCE DATA;

EID: 0030692035     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (39)

1. Harris RC, Martinez-Maldonado M: Angiotensin II-mediated renal injury. Miner Electrolyte Metab 1995;21:328-335.
2. Wolf G, Neilson EG: Angiotensin II as a renal growth factor. J Am Soc Nephrol 1993;3:1531-1540.
3. Erdös EG, Skidgel RA: Renal metabolism of angiotensin I and II. Kidney Int 1990;38(suppl 30):24-27.
4. Wolf G, Scherberich JE, Stuckhardt C, Schoeppe W: Characterization of angiotensin receptors from human kidney. Protein Biol Fluids 1987;35:289-292.
5. Taylor A: Aminopeptidases: Structure and function. FASEB J 1993;7:290-298.
6. Ahmad S, Ward PE: Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensins. J Pharmacol Exp Ther 1990;252:643-650.
7. Wu Q, Lahti JM, Air GM, Burrows PD, Cooper MD: Molecular cloning of the murine BP-1/6C3 antigen: A member of the zinc-dependent metallopeptidase family. Proc Natl Acad Sci USA 1990;87:993-997.
8. Assmann KJM, von Son JPHF, Dijkman HBPM, Koene RAP: A nephritogenic rat monoclonal antibody to mouse aminopeptidase A. Induction of massive albuminuria after a single intravenous injection. J Exp Med 1992; 175:623-635.
9. Kugler P: On angiotensin-degrading aminopeptidases in the rat kidney. Adv Anat Embryol Cell Biol 1982;76:1-85.
10. Wolf G, Scherberich JE, Schoeppe A: Glomeruli isolated from human kidney split angiotensin II: Further evidence that renal aminopeptidase A (APA) is an angiotensinase. Fresenius Z Anal Chem 1988;33:429-430.
11. Lojda Z, Gossrau R: Study on aminopeptidase A. Histochemistry 1980;67:267-290.
12. Kugler P: Localization of aminopeptidase A (angiotensinase A) in the rat and mouse kidney. Histochemistry 1981;72:269-278.
13. Ferrario CM, Brosnihan KB, Diz DI, Jaiswal N, Khosla MC, Milsted AT EA: Angiotensin (1-7): A new hormone of the angiotensin system. Hypertension 1991;18:(suppl II):126-133.
14. Mizutani S, Akiyama H, Kurauchi O, Taira H, Narita O, Tomoda Y: In vitro degradation of angiotensin II (A II) by human placental subcellular fractions, pregnancy sera and purified placental aminopeptidases. Acta Endocrinol 1985;110:135-139.
15. Wu Q, Li L, Cooper MD, Oierres M, Gorvel JP: Aminopeptidase A activity of the murine B-lymphocyte differentiation antigen BP-1/ 6C3. Proc Natl Acad Sci USA 1991;88:676-680.
16. Kerins DM, Hao Q, Vaughan DE: Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest 1995;96:2515-2520.
17. Nanus DM, Engelstein D, Gastl GA, Gluck L, Vidai MJ, Morrison M, Finstad CL, Bander NH, Albino AP: Molecular cloning of the human kidney differentiation antigen gp 260: Human aminopeptidase A. Proc Natl Acad Sci USA 1993;90:7069-7073.
18. Song L, Ye M, Troyanovskaya M, Will E, Will S, Healy DP: Rat kidney glutamyl aminopeptidase (aminopeptidase A): Molecular identity and cellular localization. Am J Physiol 1994; 267:F546-F557.
19. Li L, Wang J, Cooper MD: cDNA cloning and expression of human glutamyl aminopeptidase (aminopeptidase A). Genomics 1993;17:657-664.
20. Herzig CM, Schoeppe W, Scherberich JE: Angiotensinase A (aminopeptidase A): Properties of chromatographically purified isoforms from human kidney. J Chromatogr 1992;625:73-82.
21. Mentzel S, Dijkman HBPM, van Son JPHF, Koene RAP, Assmann KJM: Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice. J Histochem Cytochem 1996;44:445-461.
22. Wang J, Walker H, Lin Q, Jenkins N, Copeland NG, Watanabe T, Burrows PD, Cooper MD: The mouse BP-1 gene: Structure, chromosomal localization, and regulation of expression by type I interferons and interleukin-7. Genomics 1996;33:167-176.
23. Li L, Wu Q, Wang J, Bucy RP, Cooper MD: Widespread tissue distribution of aminopeptidase A, an evolutionary conserved ectoenzyme recognized by the BP-1 antibody. Tissue Antigens 1993;42:488-496.
24. Hooper NM: Families of zinc metalloproteases. FEBS Lett 1994;154:1-6.
25. Vazeux G, Wang J, Corvol P, Llorens-Cortès C: Identification of glutamate residues essential for catalytic activity and zinc coordination in aminopeptidase A. J Biol Chem 1996;271: 9069-9074.
26. Wang J, Cooper MD: Histidine residue in the zinc-binding motif of aminopeptidase A is critical for enzymatic activity. Proc Natl Acad Sci USA 1993;90:1222-1226.
27. Mentzel S, De Leeuw EPH, van Son JRHF, Dijkman HBPM, De Jong AS, Koene RAP, Assmann KJM: Characterization of a 43 kD protein associated to aminopeptidase A from murine kidney. Biol Chem Hoppe Seyler 1994; 375:623-627.
28. Stefanovic V, Vlahovic P, Ardaillou N, Ronco P, Ardaillou R: Cell surface aminopeptidase A and N activities in human glomerular epithelial cells. Kidney Int 1992;41:1571-1580.
29. Kugler P, Wolf G, Scherberich JE: Histochemical demonstration of peptidases in the human kidney. Histochemistry 1985:83:337-341.
30. Mentzel S, Assmann KJM, Dijkman HDPM, de Jong AS, van Son JPHF, Wetzels JFM, Koene RAP: Inhibition of aminopeptidase A activity causes an acute albuminuria in mice: An angiotensin II mediated effect? Nephrol Dial Transplant 1996;11:2163-2169.
31. Troyanovskaya M, Song L, Jayaraman G, HeaIy DP: Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells. Hypertension 1996;27:518-522.
32. Wolf G, Thaiss F, Scherberich JE, Schoeppe W, Stahl RAK: Glomerular angiotensinase A in the rat: Increase of enzyme activity following renal ablation. Kidney Int 1990;38:862-868.
33. Wolf G, Thaiss F, Mueller E, Dieser M, Pooth R, Zahner G, Stahl RAK: Glomerular mRNA expression of angiotensinase A after renal ablation. Exp Nephrol 1995;3:240-248.
34. Thaiss F, Wolf G, Assad N, Zahner G, Stahl RAK: Angiotensinase A gene expression and enzyme activity in isolated glomeruli of diabetic rats. Diabetologia 1996;39:275-280.
35. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J, Schwartz SM: Renal injury from angiotensin II-mediated hypertension. Hypertension 1992;19:464-474.
36. Mentzel S, Dijkman HBPM, van Son JPHF, Wetzels JFM, Koene RAP, Assmann KJM: Synergistic effect of injection of combined monoclonal antibodies (mAb) directed to different aminopeptidase A (APA) epitopes on the acute albuminuria in mice (abstract). J Am Soc Nephrol 1995;6:843.
37. Scherberich JE, Wolf G, Albers C, Nowack A, Stuckhardt C, Schoeppe W: Glomerular and tubular membrane antigens reflecting cellular adaptation in human renal failure. Kidney Int 1989;36(suppl 27):38-51.
38. Wolf G, Scherberich JE, Schoeppe W: Peptidase-associated antigens and markers of differentiation in human kidney and renal adenocarcinoma. Cell Mol Biol 1988;34:311-321.
39. Wolf G, Assmann K, Stahl RAK: Overexpression of angiotensinase A (APA) in murine mesangial cells (abstract). J Am Soc Nephrol 1996; 7:1643.