Human F(ab′)2-containing immune complexes together with anti-hinge natural antibodies stimulate complement amplification in vitro and in vivo

Molecular Immunology

Volumn 45, Issue 10, 2008, Pages 2951-2961

  Fumia, Sandra ^a   Goede, Jeroen S ^b   Fischler, Manuel ^c   Luginbühl, Alexander ^a   Frick, Sonia ^d   Fodor, Patricia ^e   Lutz, Hans U ^a  

^a ETH ZURICH   (Switzerland)

^b TRIEMLI HOSPITAL   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^d Stadtspital Triemli ^*  (Switzerland)

^e Stadtspital Triemli   (Switzerland)

Author keywords

Complement amplification; Elastase; F(ab )2; Immune complex; Naturally occurring antibody; SIRS

Indexed keywords

ANTIBODY; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; ELASTASE; HINGE ANTIBODY; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; NEUTROPHIL; PRIORITY JOURNAL; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; ANTIGEN-ANTIBODY COMPLEX; COMPLEMENT ACTIVATION; COMPLEMENT C3B; FEMALE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MALE; MIDDLE AGED; MODELS, IMMUNOLOGICAL; MOLECULAR WEIGHT; PANCREATIC ELASTASE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 41949128508     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.01.029     Document Type: Article

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