Extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) pathways involved in spinal cord stimulation (SCS)-induced vasodilation

Brain Research

Volumn 1207, Issue , 2008, Pages 73-83

  Wu, Mingyuan ^a   Komori, Naoka ^a   Qin, Chao ^a   Farber, Jay P ^a   Linderoth, Bengt ^b   Foreman, Robert D ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Extracellular signal regulated kinase; Protein kinase B; Spinal cord stimulation; Vasodilation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTRODE; FOOT PAD; LASER DOPPLER FLOWMETRY; LUMBAR SPINE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SKIN BLOOD FLOW; SPINAL CORD STIMULATION; VASCULAR RESISTANCE; VASODILATATION;

ANIMALS; BLOOD PRESSURE; BUTADIENES; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LASER-DOPPLER FLOWMETRY; MALE; MORPHOLINES; NITRILES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION; SPINAL CORD; VASCULAR RESISTANCE; VASODILATION;

RATTUS;

EID: 41949125531     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.12.072     Document Type: Article

References (53)

1. Agell N., Bachs O., Rocamora N., and Villalonga P. Modulation of the Ras/Raf/MEK/ERK pathway by Ca (2+), and calmodulin. Cell Signal. 14 (2002) 649-654
2. Armstead W.M. PTK, ERK and p38 MAPK contribute to impaired NMDA-induced vasodilation after brain injury. Eur. J. Pharmacol. 474 (2003) 249-254
3. Barron K.W., Croom J.E., Ray C.A., Chandler M.J., and Foreman R.D. Spinal integration of antidromic mediated cutaneous vasodilation during dorsal spinal cord stimulation in the rat. Neurosci. Lett. 260 (1999) 173-176
4. Brooke R.E., Atkinson L., Batten T.F., Deuchars S.A., and Deuchars J. Association of potassium channel Kv3.4 subunits with pre- and post-synaptic structures in brainstem and spinal cord. Neuroscience. 126 (2004) 1001-1010
5. Cameron T. Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review. J. Neurosurg. 100 (2004) 254-267
6. Croom J.E., Foreman R.D., Chandler M.J., and Barron K.W. Reevaluation of the role of sympathetic nervous system in cutaneous vasodilation during dorsal spinal cord stimulation: are multiple mechanisms active?. Neuromodulation 1 (1998) 91-101
7. Croom J.E., Foreman R.D., Chandler M.J., and Barron K.W. Cutaneous vasodilation during dorsal column stimulation is mediated by dorsal roots and CGRP. Am. J. Physiol. 272 (1997) 950-957
8. Croom J.E., Foreman R.D., Chandler M.J., Koss M.C., and Barron K.W. Role of nitric oxide in cutaneous blood flow increases in the rat hindpaw during dorsal column stimulation. Neurosurgery 40 (1997) 565-570 discussion 571
9. Croom, J.E., Barron, K.W., Chandler, M.J., Foreman, R.D., 1996. Cutaneous blood flow increases in the rat hindpaw during dorsal column stimulation. 728, 281-286.
10. Cui J.C., Linderoth B., and Meyerson B.A. Incidence of mononeuropathy in rats is influenced by pre-emptive alteration of spinal excitability. Eur. J. Pain 1 (1997) 53-59
11. Cui J.G., Meyerson B.A., Sollevi A., and Linderoth B. Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABA(B) and adenosine receptor activation. Neurosci. Lett. 247 (1998) 183-186
12. Cui J.G., O'Connor W.T., Ungerstedt U., Linderoth B., and Meyerson B.A. Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism. Pain 73 (1998) 87-95
13. Daulhac L., Mallet C., Courteix C., Etienne M., Duroux E., Privat A.M., Eschalier A., and Fialip J. Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-d-aspartate-dependent mechanisms. Mol. Pharmacol. 70 (2006) 1246-1254
14. Deer T.R., and Raso L.J. Spinal cord stimulation for refractory angina pectoris and peripheral vascular disease. Pain Physician 9 (2006) 347-352
15. Dolcet X., Egea J., Soler R.M., Martin-Zanca D., and Comella J.X. Activation of phosphatidylinositol 3-kinase, but not extracellular-regulated kinases, is necessary to mediate brain-derived neurotrophic factor-induced motoneuron survival. J. Neurochem. 73 (1999) 521-531
16. El-Kholy W., Macdonald P.E., Lin J.H., Wang J., Fox J.M., Light P.E., Wang Q., Tsushima R.G., and Wheeler M.B. The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism. FASEB J. 17 (2003) 720-722
17. Foreman R.D., Beall J.E., Coulter J.D., and Willis W.D. Effects of dorsal column stimulation on primate spinothalamic tract neurons. J. Neurophysiol. 39 (1976) 534-546
18. Izzo E., Martin-Fardon R., Koob G.F., Weiss F., and Sanna P.P. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nat. Neurosci. 5 (2002) 1263-1264
19. Ji R.R., Baba H., Brenner G.J., and Woolf C.J. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat. Neurosci. 2 (1999) 1114-1119
20. Kawasaki Y., Kohno T., Zhuang Z.Y., Brenner G.J., Wang H., Van-Der-Meer C., Befort K., Woolf C.J., and Ji R.R. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J. Neurosci. 24 (2004) 8310-8321
21. Komatsu T., Sakurada C., Sasaki M., Sanai K., Tsuzuki M., Bagetta G., and Sakurada T. Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior. Neuropharmacology 52 (2007) 1237-1243
22. Krens S.F., Spaink H.P., and Snaar-Jagalska B.E. Functions of the MAPK family in vertebrate-development. FEBS Lett. 580 (2006) 4984-4990
23. Lever I.J., Pezet S., McMahon S.B., and Malcangio M. The signaling components of sensory fiber transmission involved in the activation of ERK MAP kinase in the mouse dorsal horn. Mol. Cell. Neurosci. 24 (2003) 259-270
24. Lin Q., Zou X., Ren Y., Wang J., Fang L., and Willis W.D. Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin. Neuroscience 123 (2004) 337-347
25. Lin Q., Wu J., and Willis W.D. Dorsal root reflexes and cutaneous neurogenic inflammation after intradermal injection of capsaicin in rats. J. Neurophysiol. 82 (1999) 2602-2611
26. Linderoth B., and Foreman R.D. Mechanisms of spinal cord stimulation in painful syndromes: role of animal models. Pain Med. 7 (2006) S14-S26
27. Linderoth B., and Foreman R.D. Physiology of spinal cord stimulation: review and update. Neuromodulation 2 (1999) 150-164
28. Linderoth B., Herregodts P., and Meyerson B.A. Sympathetic mediation of peripheral mediation of peripheral vasodilation induced by spinal cord stimulation: animal studies of the role of cholinergic and adrenergic receptor subtypes. Neurosurgery 35 (1994) 711-719
29. Linderoth B., Fedorcsak I., and Meyerson B.A. Peripheral vasodilatation after spinal cord stimulation: animal studies of putative effector mechanisms. Neurosurgery 28 (1991) 187-195
30. Linderoth B., Gunasekera L., and Meyerson B.A. Effects of sympathectomy on skin and musclemicroculation during dorsal column stimulation: animal studies. Neurosurgery 29 (1991) 874-879
31. Lu K., Cho C.L., Liang C.L., Chen S.D., Liliang P.C., Wang S.Y., and Chen H.J. Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats. J. Thorac. Cardiovasc. Surg. 133 (2007) 934-941
32. Markus A., Zhong J., and Snider W.D. Raf and akt mediate distinct aspects of sensory axon growth. Neuron 35 (2002) 65-76
33. Rosen L.B., Ginty D.D., Weber M.J., and Greenberg M.E. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron 12 (1994) 1207-1221
34. Stiller C.O., Cui J.G., O'Connor W.T., Brodin E., Meyerson B.A., and Linderoth B. Release of γ-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery 39 (1996) 367-374 discussion 374-375
35. Sun R.Q., Tu Y.J., Yan J.Y., and Willis W.D. Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin. Pain 120 (2006) 86-96
36. Sung C.S., Wen Z.H., Chang W.K., Chan K.H., Ho S.T., Tsai S.K., Chang Y.C., and Wong C.S. Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1β-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord. J. Neurochem. 94 (2005) 742-752
37. Tanaka S., Komori N., Barron K.W., Chandler M.J., Linderoth B., and Foreman R.D. Mechanisms of sustained cutaneous vasodilation induced by spinal cord stimulation. Auton. Neurosci. 114 (2004) 55-60
38. Tanaka S., Barron K.W., Chandler M.J., Linderoth B., and Foreman R.D. Role of primary afferents in spinal cord stimulation-induced vasodilation: characterization of fiber types. Brain Res. 959 (2003) 191-198
39. Tanaka S., Barron K.W., Chandler M.J., Linderoth B., and Foreman R.D. Local cooling alters neural mechanisms producing changes in peripheral blood flow by spinal cord stimulation. Auton. Neurosci. 28 (2003) 117-127
40. Tanaka S., Barron K.W., Chandler M.J., Linderoth B., and Foreman R.D. Low intensity spinal cord stimulation may induce cutaneous vasodilation via CGRP release. Brain Res. 896 (2001) 183-187
41. Toborek M., Son K.W., Pudelko A., King-Pospisil K., Wylegala E., and Malecki A. ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons. J. Cell. Biochem. 100 (2007) 279-292
42. Walker S.M., Meredith-Middleton J., Lickiss T., Moss A., and Fitzgerald M. Primary and secondary hyperalgesia can be differentiated by postnatal age and ERK activation in the spinal dorsal horn of the rat pup. Pain 128 (2007) 157-168
43. Wang H., Dai Y., Fukuoka T., Yamanaka H., Obata K., Tokunaga A., and Noguchi K. Enhancement of stimulation-induced ERK activation in the spinal dorsal horn and gracile nucleus neurons in rats with peripheral nerve injury. Eur. J. Neurosci. 19 (2004) 884-890
44. Willis Jr. W.D. Dorsal root potentials and dorsal root reflexes: a double-edged sword. Exp. Brain Res. 124 (1999) 395-421
45. Wu M., Komori N., Qin C., Farber J.P., Linderoth B., and Foreman R.D. Roles of peripheral terminals of transient receptor potential vanilloid-1 containing sensory fibers in spinal cord stimulation-induced peripheral vasodilation. Brain Res. 1156 (2007) 80-92
46. Wu M., Thorkilsen M., Qin C., Farber J.P., Linderoth B., and Foreman R.D. Effects of spinal cord stimulation on peripheral circulation in stretozotocin-induced diabetic rats. Neuromodulation 10 (2007) 217-223
47. Wu M., Linderoth B., and Foreman R.D. Putative mechanisms behind effects of spinal cord stimulation on vascular diseases: a review of experimental studies. Auton. Neurosci. 138 (2008) 9-23
48. Wu J., Su G., Ma L., Zhang X., Lei Y., Li J., Lin Q., and Fang L. Protein kinases mediate increment of the phosphorylation of cyclic AMP-responsive element binding protein in spinal cord of rats following capsaicin injection. Mol. Pain 1 (2005) 1-26
49. Wu M., Komori N., Qin C., Farber J.P., Linderoth B., and Foreman R.D. Sensory fibers containing vanilloid receptor-1(VR-1) mediate spinal cord stimulation-induced vasodilation. Brain Res. 1107 (2006) 177-184
50. Wu M., Komori N., Qin C., Farber J.P., Linderoth B., and Foreman R.D. Extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) pathways involved in spinal cord stimulation (SCS)-induced vasodilation. FASEB J. 20 (2006) A1402
51. Xin W.J., Gong Q.J., Xu J.T., Yang H.W., Zang Y., Zhang T., Li Y.Y., and Liu X.G. Role of phosphorylation of ERK in induction and maintenance of LTP of the C-fiber evoked field potentials in spinal dorsal horn. J. Neurosci. Res. 84 (2006) 934-943
52. Yang L., Zhu C.J., Cao J.L., and Zeng Y.M. Inhibition of the spinal phosphoinositide 3-kinase exacerbates morphine withdrawal response. Neurosci. Lett. 404 (2006) 237-241
53. Zhuang Z.Y., Xu H., Clapham D.E., and Ji R.R. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J. Neurosci. 24 (2004) 8300-8309