Inhibition of the spinal phosphoinositide 3-kinase exacerbates morphine withdrawal response

Neuroscience Letters

Volumn 404, Issue 1-2, 2006, Pages 237-241

  Yang, Li ^a   Zhu, Chang Jiang ^a   Cao, Jun Li ^a,b   Zeng, Yin Ming ^a,b  

^a Jiangsu Institute of Anesthesiology   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Morphine dependence; Phosphoinositide 3 kinase; Sensitization; Spinal cord; Substance withdrawal syndrome

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; MORPHINE; NALOXONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN FOS; PROTEIN P110; WORTMANNIN;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DOWN REGULATION; DRUG WITHDRAWAL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CHROMONES; DIMETHYL SULFOXIDE; MALE; MICE; MICE, INBRED STRAINS; MORPHINE DEPENDENCE; MORPHOLINES; SPINAL CORD; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 33745880124     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.05.056     Document Type: Article

References (26)

1. Bell J.A., and Beglan C.L. Co-treatment with MK-801 potentiates naloxone-precipitated morphine withdrawal in the isolated spinal cord of the neonatal rat. Eur. J. Pharmacol. 294 (1995) 297-301
2. Buccafusco J.J., Terry A.V., and Shuster L. Spinal NMDA receptor-nitric oxide mediation of the expression of morphine withdrawal symptoms in the rat. Brain Res. 679 (1995) 189-199
3. Busca R., Bertolotto C., Ortonne J.P., and Ballotti R. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation. J. Biol. Chem. 271 (1996) 31824-31830
4. Cao J.L., He J.H., Ding H.L., and Zeng Y.M. Activation of the spinal ERK signaling pathway contributes naloxone-precipitated withdrawal in morphine-dependent rats. Pain 118 (2005) 336-349
5. Delander G.E., and Takemori A.E. Spinal antagonism of tolerance and dependence induced by systemically administered morphine. Eur. J. Pharmacol. 94 (1983) 35-42
6. Hylden J.L.K., and Wilcox G.L. Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. 67 (1980) 313-316
7. Izzo E., Martin-Fardon R., Koob G.F., Weiss F., and Sanna P.P. Neural plasticity and addition: PI3-kinase and cocaine behavioral sensitization. Nat. Neurosci. 5 (2002) 1263-1264
8. Kauer J.A. Learning mechanisms in addiction: synaptic plasticity in the ventral tegmental area as a result of exposure to drugs of abuse. Annu. Rev. Physiol. 66 (2004) 447-475
9. Kerfant B.G., Gidrewicz D., Sun H., Oudit G.Y., Penninger J.M., and Backx P.H. Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ. Res. 96 (2005) 1079-1086
10. Kim S., Jee K., Kim D., Koh H., and Chung J. Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J. Biol. Chem. 276 (2001) 12864-12870
11. Le Guen S., Gestreau C., and Besson J.M. Sensitivity to naloxone of the behavioral signs of morphine withdrawal and c-Fos expression in the rat CNS: a quantitative dose-response analysis. J. Comp. Neurol. 433 (2001) 272-296
12. Lin C.H., Yeh S.H., Lin C.H., Lu K.T., Leu T.H., Chang W.C., and Gean P.W. A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron 31 (2001) 841-851
13. Luconi M., Carloni V., Marra F., Ferruzzi P., Forti G., and Baldi E. Increased phosphorylation of AKAP by inhibition of phosphatidylinositol 3-kinase enhances human sperm motility through tail recruitment of protein kinase A. J. Cell Sci. 117 (2004) 1235-1246
14. Miyamoto Y., and Takemori A.E. Sites of action of naloxone in precipitating withdrawal jumping in morphine-dependent mice: investigations by the ED50 value and CNS content of naloxone. Drug Alcohol Depend. 32 (1993) 163-167
15. Nestler E.J. Historical review: molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol. Sci. 25 (2004) 210-218
16. Ozek M., Uresin Y., and Gungor M. Comparison of the effects of specific and nonspecific inhibition of nitric oxide synthase on morphine analgesia, tolerance and dependence in mice. Life Sci. 72 (2003) 1943-1951
17. Pahan K., Liu X., Wood C., and Raymond J.R. Expression of a constitutively active form of phosphatidylinositol 3-kinase inhibits the induction of nitric oxide synthase in human astrocytes. FEBS Lett. 472 (2000) 203-207
18. Park Y.C., Lee C.H., Kang H.S., Chung H.T., and Kim H.D. Wortmannin a specific inhibitor of phosphatidylinositol-3-kinase, enhances LPS-induced NO production from murine peritoneal macrophages. Biochem. Biophys. Res. Commun. 240 (1997) 692-696
19. Poser S., Impey S., Xia Z., and Storm D.R. Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMP. J. Neurosci. 23 (2003) 4420-4427
20. Pyo H., Yang M.S., Jou I., and Joe E.H. Wortmannin enhances lipopolysaccharide-induced inducible nitric oxide synthase expression in microglia in the presence of astrocytes in rats. Neurosci. Lett. 346 (2003) 141-144
21. Rohde D.S., McKay W.R., Abbadie C., and Basbaum A.I. Contribution of sacral spinal cord neurons to the autonomic and somatic consequences of withdrawal from morphine in the rat. Brain Res. 745 (1997) 83-95
22. Sanna P.P., Cammalleri M., Berton F., Simpson C., Lutjens R., and Bloom F.E. Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region. J. Neurosci. 22 (2002) 3359-3365
23. Spehr M., Wetzel C.H., Hatt H., and Ache B.W. 3-Phosphoinositides modulate cyclic nucleotide signaling in olfactory receptor neurons. Neuron 33 (2002) 731-739
24. Sweitzer S.M., Wong S.M., Tjolsen A., Allen C.P., Mochly-Rosen D., and Kendig J.J. Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma. Pain 110 (2004) 281-289
25. Wolf D.H., Numan S., Nestler E.J., and Russell D.S. Regulation of phospholipase C gamma in the mesolimbic dopamine system by chronic morphine administration. J. Neurochem. 73 (1999) 1520-1528
26. Zhu H.B., and Barr G.A. Opiate withdrawal during development: are NMDA receptors indispensable?. Trends Neurosci. 22 (2001) 404-408