Characterization of the basal promoter element of human organic cation transporter 2 gene

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 2, 2007, Pages 684-689

  Asaka, Jun Ichi ^a   Terada, Tomohiro ^a   Ogasawara, Ken ^a   Katsura, Toshiya ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT BINDING FACTOR; COMPLEMENTARY DNA; DNA; DNA FRAGMENT; HELIX LOOP HELIX PROTEIN; LEUCINE ZIPPER PROTEIN; NUCLEOTIDE DERIVATIVE; ORGANIC CATION TRANSPORTER 2; TRANSCRIPTION FACTOR; UPSTREAM STIMULATORY FACTOR 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG ISOLATION; E BOX ELEMENT; GEL MOBILITY SHIFT ASSAY; GENE AMPLIFICATION; GENE DELETION; GENE ISOLATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RNA TRANSLATION; TATA BOX;

5' FLANKING REGION; BASE SEQUENCE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; ORGANIC CATION TRANSPORT PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TRANSCRIPTION INITIATION SITE; UPSTREAM STIMULATORY FACTORS;

EID: 34247200048     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.118695     Document Type: Article

References (40)

1. Alves S, Amorim A, Ferreira F, and Prata MJ (2001) Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity. Clin Pharmacol Ther 70:165-174.
2. Asaka J, Terada T, Okuda M, Katsura T, and Inui K (2006) Androgen receptor is responsible for rat organic cation transporter 2 gene regulation but not for rOCT1 and rOCT3. Pharm Res (NY) 23:697-704.
3. Biermann J, Lang D, Gorboulev V, Koepsell H, Sindic A, Schröter R, Zvirbliene A, Pavenstädt H, Schlatter E, and Ciarimboli G (2006) Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol 290:C1521-C1531.
4. Buckland PR (2006) The importance and identification of regulatory polymorphisms and their mechanisms of action. Biochim Biophys Acta 1762:17-28.
5. Çetinkaya I, Ciarimboli G, Yalçinkaya G, Mehrens T, Velic A, Hirsch JR, Gorboulev V, Koepsell H, and Schlatter E (2003) Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinase. Am J Physiol 284:F293-F302.
6. Chen L, Shen YH, Wang X, Wang J, Gan Y, Chen N, Wang J, LeMaire SA, Coselli JS, and Wang XL (2006) Human prolyl-4-hydroxylase α(I) transcription is mediated by upstream stimulatory factors. J Biol Chem 281:10849-10855.
7. Ciarimboli G, Ludwig T, Lang D, Pavenstädt H, Koepsell H, Piechota HJ, Haier J, Jaehde U, Zisowsky J, and Schlatter E (2005) Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 167:1477-1484.
8. Corre S and Galibert MD (2005) Upstream stimulating factors: highly versatile stress-responsive transcription factors. Pigment Cell Res 18:337-348.
9. Fujii G, Nakamura Y, Tsukamoto D, Ito M, Shiba T, and Takamatsu N (2006) CpG methylation at the USF-binding site is important for the liver-specific transcription of the chipmunk HP-27 gene. Biochem J 395:203-209.
10. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, and Koepsell H (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16:871-881.
11. Hock TD, Nick HS, and Agarwal A (2004) Upstream stimulatory factors, USF1 and USF2, bind to the human haem oxygenase-1 proximal promoter in vivo and regulate its transcription. Biochem J 383:209-218.
12. Inui K, Masuda S, and Saito H (2000) Cellular and molecular aspects of drug transport in the kidney. Kidney Int 58:944-958.
13. Iyer L, Das S, Janisch L, Wen M, Ramirez J, Karrison T, Fleming GF, Vokes EE, Schilsky RL, and Ratain MJ (2002) UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2:43-47.
14. Jonker JW and Schinkel AH (2004) Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). J Pharmacol Exp Ther 308:2-9.
15. Kantartzis K, Fritsche A, Machicao F, Stumvoll M, Machann J, Schick F, Häring HU, and Stefan N (2007) Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactions. J Mol Med 85:55-61.
16. Kikuchi R, Kusuhara H, Hattori N, Shiota K, Kim I, Gonzalez FJ, and Sugiyama Y (2006) Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1 α/β and DNA methylation. Mol Pharmacol 70:887-896.
17. Kimura N, Okuda M, and Inui K (2005) Metformin transport by renal basolateral organic cation transporter hOCT2. Pharm Res (NY) 22:255-259.
18. Koepsell H (1998) Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 60:243-266.
19. Mandola MV, Stoehlmacher J, Muller-Weeks S, Cesarone G, Yu MC, Lenz HJ, and Ladner RD (2003) A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 63:2898-2904.
20. Mantovani R (1999) The molecular biology of the CCAAT-binding factor NF-Y. Gene (Amst) 239:15-27.
21. +/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 17:2127-2135.
22. Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, and Inui K (2002) Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol 13:866-874.
23. Nagato H, Matsuo N, Sumiyoshi H, Sakata-Takatani K, Nasu M, and Yoshioka H (2004) The transcription factor CCAAT-binding factor CBF/NF-Y and two repressors regulate the core promoter of the human pro-α3(V) collagen gene (COL5A3). J Biol Chem 279:46373-46383.
24. Ogasawara K, Terada T, Asaka J, Katsura T, and Inui K (2006) Human organic anion transporter 3 gene is regulated constitutively and inducibly via a cAMPresponse element. J Pharmacol Exp Ther 319:317-322.
25. Otsuka M, Matsumoto T, Morimoto R, Arioka S, Omote H, and Moriyama Y (2005) A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci USA 102:17923-17928.
26. Pajukanta P, Lilja HE, Sinsheimer JS, Cantor RM, Lusis AJ, Gentile M, Duan XJ, Soro-Paavonen A, Naukkarinen J, Saarela J, et al. (2004) Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet 36:371-376.
27. Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cascon D, Greenberg G, et al. (2004) Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet 36:471-475.
28. Popowski K, Eloranta JJ, Saborowski M, Fried M, Meier PJ, and Kullak-Ublick GA (2005) The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4α and suppressed by bile acids. Mol Pharmacol 67:1629-1638.
29. Ramji DP and Foka P (2002) CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J 365:561-575.
30. Saborowski M, Kullak-Ublick GA, and Eloranta JJ (2006) The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4α. J Pharmacol Exp Ther 317:778-785.
31. 1. Am J Physiol 262:C59-C66.
32. Sawadogo M and Roeder RG (1985) Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell 43:165-175.
33. Shimakura J, Terada T, Katsura T, and Inui K (2005) Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1. Am J Physiol 289:G471-G477.
34. Sirito M, Lin Q, Maity T, and Sawadogo M (1994) Ubiquitous expression of the 43-and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res 22:427-433.
35. Terada T and Inui K (2007) Gene expression and regulation of drug transporters in the intestine and kidney. Biochem Pharmacol 73:440-449.
36. +/organic cation antiporter MATE1. Pharm Res (NY) 23:1696-1701.
37. Tsuruoka S, Ioka T, Wakaumi M, Sakamoto K, Ookami H, and Fujimura A (2006) Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2. Clin Pharmacol Ther 79:389-396.
38. Urakami Y, Akazawa M, Saito H, Okuda M, and Inui K (2002) cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol 13:1703-1710.
39. Yanai K, Saito T, Hirota K, Kobayashi H, Murakami K, and Fukamizu A (1997) Molecular variation of the human angiotensinogen core promoter element located between the TATA box and transcription initiation site affects its transcriptional activity. J Biol Chem 272:30558-30562.
40. Yonezawa A, Masuda S, Yokoo S, Katsura T, and Inui K (2006) Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther 319:879-886.