Epigenetic regulation of EpCAM in tumor invasion and metastasis

Journal of Cancer Molecules

Volumn 3, Issue 6, 2008, Pages 165-168

  Shiah, Shine Gwo ^a   Tai, Kang Yu ^a   Wu, Cheng Wen ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

EpCAM; Epigenetic; Invasion; Promoter methylation

Indexed keywords

ANTINEOPLASTIC AGENT; EPITHELIAL CELL ADHESION MOLECULE; EPITHELIAL CELL ADHESION MOLECULE ANTIBODY; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; UNCLASSIFIED DRUG;

ACETYLATION; CANCER CELL; CANCER DIAGNOSIS; CANCER GROWTH; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CANCER INVASION; CANCER PREVENTION; CANCER STAGING; CANCER THERAPY; CELL INTERACTION; CELL SURFACE; CHROMATIN; CPG ISLAND; DEACETYLATION; DEMETHYLATION; DISEASE ASSOCIATION; DISEASE MARKER; DNA METHYLATION; DRUG MECHANISM; EPIGENETICS; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; LUNG ADENOCARCINOMA; METASTASIS; METHYLATION; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; REGULATORY MECHANISM; REVIEW; TUMOR GROWTH;

EID: 41949109583     PISSN: 18160735     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Thiery JP. The saga of adhesion molecules. J Cell Biochem 61: 489-492, 1996.
2. Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO. Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 125, 437-446, 1994.
3. Winter MJ, Nagtegaal ID, van Krieken JR, Litvinov SV. The epithelial cell adhesion molecule (Ep-CAM) as a morpho-regulatory molecule is a tool in surgical pathology. Am J Pathol 163: 2139-2148, 2003.
4. Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K. Retroposition in a family of carcinoma-associated antigen genes. Mol Cell Biol 13: 1507-1515, 1993.
5. Momburg F, Moldenhouer G,, Hammerling GJ, Moller P. Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein In normal and malignant tissues. Cancer Res 47: 2883-2891, 1987.
6. Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O. The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene 23: 5748-5758, 2004.
7. Fidler IJ. Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38: 2651-2660, 1978.
8. Joo M, Kim H, Kim MK, Yu HJ, Kim JP. Expression of Ep-CAM in Intestinal mataplasia, gastric epithelial dysplania and gastric adenocarcinoma. J Gastroenteorol Hepatol 20: 1039-1045, 2005.
9. Kim JR, Herlyn D, Wong KK, Park DC, Schorge JO, Lu KH, Skates SJ, Cramer DW, Berkowitz RS, Mok SC. Identification of epithelial cell adhesion molecule autoantibody in patients with ovarian cancer. Clin Cancer Res 9: 4782-4791, 2003.
10. Songun I, Litvinov SV, van do Velde CJ, Pals ST, Hermans J, van Krieken JH. Loss of Ep-CAM (CO17-1A) expression predicts survival in patients with gastric cancer. Br J Cancer 92: 1767-1772, 2005.
11. Rao CG, Chlanese D, Doyle GV, Miller MC, Russell T, Sanders RA Jr, Terstappen LW. Expression of epithelial cell adhesion molecule In carcinoma cells present in blood and primary and metastatic tumors. Int J Oncol 27: 49-57, 2005.
12. Tai KY, Shlah SG, Shieh YS, Kao YR, Chi CY, Huang E, Lee HS, Chang LC, Yang PC, Wu CW. DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression. Oncogene 26: 3989-3997, 2007.
13. Takes RP, Baatenburg de Jong RJ, Wijttels K, Schuuring E, Litvinov SV, Hermans J, van Krieken JH. Expression of genetic markers in lymph node matastases compared with their primary tumours in head and neck cancer. J Pathol 194: 298-302, 2001.
14. Jojovic M, Adam E, Zangemelster-Wittke U, Schumacher U. Epithelial glycoprotein-2 expression is subject to regulatory processes in epithelial-mesenchymal transitions during metastases: an investigation of human cancers transplanted into severe combined immunodeficient mice. Histochem J 30: 723-729, 1998.
15. Gastl G, Spizzo G, Obrist P, Dunser M, Mikuz G. Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 356: 1981-1982, 2000.
16. Osta WA, Chen Y, Mikhitarian K, Mitas M, Salem M, Hannun YA, Cole DJ, Gilianders WE. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 64: 5818-5824, 2004.
17. Armstrong A, Eck SL. EpCAM: A new therapeutic target for an old cancer antigen. Cancer Biol Ther 2: 320-326, 2003.
18. Went P, Vasell M, Subendorf L, Terracclano L, Tornillo L, Riede U, Kononen J, Simon R, Sauter G, Baeuerle PA. Frequent high-level expression of the Immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers. Br J Cancer 94: 128-135, 2006.
19. Seligson DB, Pantuck AJ, Liu X, Huang Y, Horvath S, Bul MH, Han KR, Correa AJ, Eeva M, Tze S, Belldegrun AS, Figlin RA. Epithelial cell adhesion molecule (KSA) expression: pathobiology and its role as an Independent predictor of survival in renal cell carcinoma. Clin Cancer Res 10: 2659-2669, 2004.
20. Suzuki H, Gabrielson E, Chen W, Anbazhagen R, van Engeland M, Weijenberg MP, Herman JG, Baylin SB. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 31: 141-149, 2002.
21. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428, 2002.
22. Melki JR, Vincent PC, Clark SJ. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res 59: 3730-3740, 1999.
23. Gires O, Eskofier S, Lang S, Zeldler R, Munz M. Cloning and characterization of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter. Anticancer Res 23: 3255-3261, 2003.
24. McLaughlin PM, Trzpis M, Kroesen BJ, Helfrich W, Terpstra P, Dokter WH, Ruiters MH, de Lelj LF, Harmsen MC. Use of the EGP-2/Ep-CAM promoter for targeted expression of heterologous genes in carcinoma derived cell lines. Cancer Gene Ther 11: 603-612, 2004.
25. Alberti S, Nutini M, Herzenberg LA. DNA methylation prevents the amplification of TROP1, a tumor-associated cell surface antigen gene. Proc Natl Acad Sci USA 91: 5833-6837, 1994.
26. Spizzo G, Gastl G, Obrist P, Fong D, Haun M, Grunewald K, Parson W, Elchmann C, Millinger S, Flegl H, Margreiter R, Amberger A. Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue. Cancer Lett 246: 253-261, 2007.
27. Bird AP, Wolffe AP. Methylation-Induced repression-beits, braces, and chromatin Cell 99, 451-454, 1999.
28. Jenuwein T, Allis CD. Translating the histone code. Science 293: 1074-1080, 2001.
29. Margueron R, Trojer P, Reinberg D. The key to development: interpreting the histone code? Curr Opin Genet Dev 15: 163-176, 2006.
30. Fuks F. DNA methylatin and histone modifications: teaming up to silence genes. Curr Opin Genet Dev 15: 493-495, 2005.
31. Hung KF, Chang CS, Liu CJ, Lui MT, Cheng CY, Kao SY. Differential expression of E-cadherin in metastatic lesions comparing to primary oral equamous cell carcinoma. J Oral Pathol Med 35. 589-594, 2006.
32. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF, Isaacs WS, Pitha PM, Davidson NE, Baylin SB. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55: 5195-5199, 1995.
33. Basak S, Eck S, Gutzmer R, Smith AJ, Birebent B, Purev E, Stalb L, Somasundaram R, Zaloudik J, Li W, Jacob L, Mitchell E, Speicher D, Herlyn D. Colorectal cancer vaccines: antiidiotypic antibody, recombinant protein, and viral vector. Ann N Y Acad Sci 910: 237-252; discussion 252-233, 2000.
34. Takes RP, Baatenburg de Jong RJ, Schuuring E, Hermans J, Vis AA, Litvinov SV, van Krieken JH. Markers for assessment of nodal metastasis in laryngeal carcinoma. Arch Otolaryngol Head Neck Surg 123: 412-419, 1997.
35. Chaudry MA, Sales K, Ruf P, Lindhofer H, Winslet MC. EpCAM an Immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges. Br J Cancer 96: 1013-1019, 2007.
36. Szyf M, Pakneshan P, Rabbani SA. DNA demethylation and cancer: therapeutic implications. Cancer Lett 211: 133-143, 2004.