Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts - A comparative study

Toxicology and Applied Pharmacology

Volumn 228, Issue 3, 2008, Pages 269-276

  van Meeuwen, J A ^a   Nijmeijer, S ^a   Mutarapat, T ^b   Ruchirawat, S ^b   de Jong, P C ^c   Piersma, A H ^d   van den Berg, M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b Toxicology and Management of Chemicals   (Thailand)

^c ST ANTONIUS HOSPITAL   (Netherlands)

^d NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Aromatase; Flavonoids; Human breast fibroblasts; Human placental microsomes; Synthetic lactones

Indexed keywords

3 (3,4 DIMETHOXYPHENYL) 4 (4 METHOXYPHENYL) 2(5H) FURANONE; 3 (3,4 DIMETHOXYPHENYL) 4 (4 TRIMETHOXYPHENYL) 2(5H) FURANONE; 3,4 BIS(3,4 DIMETHOXYPHENYL) 2(5H) FURANONE; 4 HYDROXY ANDROSTENEDIONE; 4',5,7 HYDROXY 8 PRENYLNARINGENIN; 8 PRENYLNARINGENIN; APIGENIN; APIGENIN 4',5,7 HYDROXYFLAVONE; AROMATASE; AROMATASE INHIBITOR; CHRYSIN; CHRYSIN 5,7 HYDROXYFLAVONE; FADROZOLE; FLAVANONE; FLAVONOID; IMIDAZOLE; LACTONE; NARINGENIN; TM 7; TM 8; TM 9; UNCLASSIFIED DRUG;

ARTICLE; BREAST; BREAST CANCER; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROSOME; PHARMACOLOGICAL BLOCKING; PLACENTA; PREDICTION; WHOLE CELL;

AROMATASE INHIBITORS; BREAST; CATALYSIS; CELLS, CULTURED; FEMALE; FIBROBLASTS; FLAVONOIDS; HUMANS; LACTONES; MICROSOMES; PLACENTA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41949100742     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.12.007     Document Type: Article

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