Human CAR gene expression in nonpermissive hamster cells boosts entry of type 12 adenovirions and nuclear import of viral DNA

Journal of Virology

Volumn 82, Issue 8, 2008, Pages 4159-4163

  Hochstein, Norbert ^a,d,e   Webb, Dennis ^b,e   Hösel, Marianna ^b   Seidel, Werner ^c   Auerochs, Sabrina ^a   Doerfler, Walter ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF GREIFSWALD   (Germany)

^d UPPSALA UNIVERSITY   (Sweden)

^e NewLab BioQuality AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; VIRUS DNA; CXADR PROTEIN, HUMAN; UNCLASSIFIED DRUG; VIRUS RECEPTOR;

ADENOVIRUS 12; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOPLASM; DNA REPLICATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRION; VIRUS ASSEMBLY; VIRUS DNA CELL DNA INTERACTION; VIRUS ENTRY; VIRUS INFECTION; ACTIVE TRANSPORT; ADENOVIRUS; ANIMAL; BIOSYNTHESIS; CELL LINE; COMPARATIVE STUDY; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY; VIROLOGY; VIRUS REPLICATION;

ADENOVIRIDAE; CRICETINAE; HUMAN ADENOVIRUS TYPE 12;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOVIRIDAE; ANIMALS; CELL LINE; CELL NUCLEUS; CRICETINAE; DNA, VIRAL; RECEPTORS, VIRUS; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 41949098320     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02657-07     Document Type: Article

References (27)

1. Bergelson, J. M., J. A. Cunningham, G. Droguett, E. A. Kurt-Jones, A. Krithivas, J. S. Hong, M. S. Horwitz, R. L. Crowell, and R. W. Finberg. 1997. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320-1323.
2. Burger, H., and W. Doerfler. 1974. Intracellular forms of adenovirus DNA. 3. Integration of the DNA of adenovirus type 2 into host DNA in productively infected cells. J. Virol. 13:975-992.
3. Deuring, R., and W. Doerfler. 1983. Proof of recombination between viral and cellular genomes in human KB cells productively infected by adenovirus type 12: structure of the junction site in a symmetric recombinant (SYREC). Gene 26:283-289.
4. Deuring, R., G. Klotz, and W. Doerfler. 1981. An unusual symmetric recombinant between adenovirus type 12 DNA and human cell DNA. Proc. Natl. Acad. Sci. USA 78:3142-3146.
5. Doerfler, W. 1968. 1968. The fate of the DNA of adenovirus type 12 in baby hamster kidney cells. Proc. Natl. Acad. Sci. USA 60:636-643.
6. Doerfler, W. 1969. Nonproductive infection of baby hamster kidney cells (BHK21) with adenovirus type 12. Virology 38:587-606.
7. Doerfler, W. 2007. Human adenovirus type 12: crossing species barriers to immortalize the viral genome. Methods Mol. Med. 131:197-211.
8. Hochstein, N., I. Muiznieks, L. Mangel, H. Brondke, and W. Doerfler. 2007. The epigenetic status of an adenovirus transgenome upon long-term cultivation in hamster cells. J. Virol. 81:5349-5361.
9. Hohlweg, U., A. Dorn, M. Hosel, D. Webb, R. Buettner, and W. Doerfler. 2004. Tumorigenesis by adenovirus type 12 in newborn Syrian hamsters. Curr. Top. Microbiol. Immunol. 273:215-244.
10. Hösel, M., D. Webb, J. Schroer, and W. Doerfler. 2003. The abortive infection of Syrian hamster cells with human adenovirus type 12. Curr. Top. Microbiol. Immunol. 272:415-440.
11. Hösel, M., D. Webb, J. Schröer, B. Schmitz, and W. Doerfler. 2001. Overexpression of the adenovirus type 12 (Ad12) pTP or E1A gene facilitates Ad12 DNA replication in nonpermissive BHK21 hamster cells. J. Virol. 75:10041-10053.
12. Knoblauch, M., J. Schröer, B. Schmitz, and W. Doerfler. 1996. The structure of adenovirus type 12 DNA integration sites in the hamster cell genome. J. Virol. 70:3788-3796.
13. Law, L. K., and B. L. Davidson. 2005. What does it take to bind CAR? Mol. Ther. 12:599-609.
14. Li, J., S. Lad, G. Yang, Y. Luo, M. Iacobelli-Martinez, F. J. Primus, R. A. Reisfeld, and E. Li. 2006. Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery. J. Virol. 80:12324-12331.
15. Lonberg-Holm, K., and L. Philipson. 1969. Early events of virus-cell interaction in an adenovirus system. J. Virol. 4:323-338.
16. Lundholm, U., and W. Doerfler. 1971. Temperature-sensitive mutants of human adenovirus type 12. Virology 45:827-829.
17. Nemerow, G. R., and P. L. Stewart. 1999. Role of alpha(v) integrins in adenovirus cell entry and gene delivery. Microbiol. Mol. Biol. Rev. 63:725-734.
18. Philipson, L., and R. F. Pettersson. 2004. The coxsackie-adenovirus receptor - a new receptor in the immunoglobulin family involved in cell adhesion. Curr. Top. Microbiol. Immunol. 273:87-111.
19. Pickles, R. J., D. McCarty, H. Matsui, P. J. Hart, S. H. Randell, and R. C. Boucher. 1998. Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer. J. Virol. 72:6014-6023.
20. Schiedner, G., B. Schmitz, and W. Doerfler. 1994. Late transcripts of adenovirus type 12 DNA are not translated in hamster cells expressing the E1 region of adenovirus type 5. J. Virol. 68:5476-5482.
21. Schröer, J., I. Hölker, and W. Doerfler. 1997. Adenovirus type 12 DNA firmly associates with mammalian chromosomes early after virus infection or after DNA transfer by the addition of DNA to the cell culture medium. J. Virol. 71:7923-7932.
22. Sirena, D., B. Lilienfeld, M. Eisenhut, S. Kalin, K. Boucke, R. R. Beerli, L. Vogt, C. Ruedl, M. F. Bachmann, U. F. Greber, and S. Hemmi. 2004. The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3. J. Virol. 78:4454-4462.
23. Strohl, W. A. 1969. The response of BHK21 cells to infection with type 12 adenovirus. II. Relationship of virus-stimulated DNA synthesis to other viral functions. Virology 39:653-665.
24. Trentin, J. J., Y. Yabe, and G. Taylor. 1962. The quest for human cancer viruses. Science 137:835-841.
25. Visser, L., M. W. van Maarschalkerweerd, T. H. Rozijn, A. D. Wassenaar, A. M. Reemst, and J. S. Sussenbach. 1980. Viral DNA sequences in adenovirus-transformed cells. Cold Spring Harbor Symp. Quant. Biol. 44:541-550.
26. Walters, R. W., W. van't Hof, S. M. Yi, M. K. Schroth, J. Zabner, R. G. Crystal, and M. J. Welsh. 2001. Apical localization of the coxsackie-adenovirus receptor by glycosyl-phosphatidylinositol modification is sufficient for adenovirus-mediated gene transfer through the apical surface of human airway epithelia. J. Virol. 75:7703-7711.
27. Xia, D., L. J. Henry, R. D. Gerard, and J. Deisenhofer. 1994. Crystal structure of the receptor-binding domain of adenovirus type 5 fiber protein at 1.7 A resolution. Structure 2:1259-1270.