Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery

Journal of Virology

Volumn 80, Issue 24, 2006, Pages 12324-12331

  Li, Jiali ^a   Lad, Sonya ^a   Yang, Guang ^a   Luo, Yunping ^a   Iacobelli Martinez, Milena ^a   Primus, F James ^b   Reisfeld, Ralph A ^a   Li, Erguang ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTIBODY; CELL SURFACE RECEPTOR; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; GROWTH FACTOR; HYBRID PROTEIN; LIGAND;

ADENOVIRUS 2; ADENOVIRUS 5; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONTROLLED STUDY; GENE EXPRESSION; GENE INSERTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRION; VIRUS ADSORPTION;

ADENOVIRIDAE; ANIMALS; ANTIBODIES, MONOCLONAL; CAPSID PROTEINS; CELL LINE; DNA PRIMERS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIGANDS; MICE; POLYMERASE CHAIN REACTION; POLYMERS; RECEPTORS, VIRUS;

ADENOVIRIDAE;

EID: 33845465074     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01331-06     Document Type: Article

References (53)

1. Alba, R., A. Bosch, and M. Chillon. 2005. Gutless adenovirus: last-generation adenovirus for gene therapy. Gene Ther. 12(Suppl. 1):S18-S27.
2. Alemany, R., C. Balague, and D. T. Curiel. 2000. Replicative adenoviruses for cancer therapy. Nat. Biotechnol. 18:723-727.
3. Barouch, D. H., and G. J. Nabel. 2005. Adenovirus vector-based vaccines for human immunodeficiency virus type 1. Hum. Gene Ther. 16:149-156.
4. Baserga, R. 1999. The IGF-I receptor in cancer research. Exp. Cell Res. 253:1-6.
5. Bergelson, J. M., J. A. Cunningham, G. Droguett, E. A. Kurt-Jones, A. Krithivas, J. S. Hong, M. S. Horwitz, R. L. Crowell, and R. W. Finberg. 1997. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320-1323.
6. Bischoff, J. R., D. H. Kirn, A. Williams, C. Heise, S. Horn, M. Muna, L. Ng, J. A. Nye, A. Sampson-Johannes, A. Fallaey, and F. McCormick. 1996. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274:373-376.
7. Carson, S. D., N. N. Chapman, and S. M. Tracy. 1997. Purification of the putative coxsackievirus B receptor from Hela cells. Biochem. Biophys. Res. Commun. 233:325-328.
8. Chappell, J. D., A. E. Prota, T. S. Dermody, and T. Stehle. 2002. Crystal structure of reovirus attachment protein σ1 reveals evolutionary relationship to adenovirus fiber. EMBO J. 21:1-11.
9. Check, E. 2002. Regulators split on gene therapy as patient shows signs of cancer. Nature 419:545-546.
10. Chroboczek, J., R. W. Ruigrok, and S. Cusack. 1995. Adenovirus fiber. Curr. Top. Microbiol. Immunol. 199:163-200.
11. Curiel, D. T. 1999. Strategies to adapt adenoviral vectors for targeted delivery. Ann. N. Y. Acad. Sci. 886:158-171.
12. Ferber, D. 2001. Gene therapy. Safer and virus-free? Science 294:1638-1642.
13. Fraser, R. D., D. B. Furlong, B. L. Trus, M. L. Nibert, B. N. Fields, and A. C. Steven. 1990. Molecular structure of the cell-attachment protein of reovirus: correlation of computer-processed electron micrographs with sequence-based predictions. J. Virol. 64:2990-3000.
14. Gaden, F., L. Franqueville, M. K. Magnusson, S. S. Hong, M. D. Merten, L. Lindholm, and P. Boulanger. 2004. Gene transduction and cell entry pathway of fiber-modified adenovirus type 5 vectors carrying novel endocytic peptide ligands selected on human tracheal glandular cells. J. Virol. 78:7227-7247.
15. Goldman, M. J., and J. M. Wilson. 1995. Expression of αvβ5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. J. Virol. 69:5951-5958.
16. Gu, J., S. Kagawa, M. Takakura, S. Kyo, M. Inoue, J. A. Roth, and B. Fang. 2000. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res. 60:5359-5364.
17. Hardy, S., M. Kitamura, T. Harris-Stansil, Y. Dai, and M. L. Phipps. 1997. Construction of adenovirus vectors through Cre-lox recombination. J. Virol. 71:1842-1849.
18. He, T. C., S. Zhou, L. T. da Costa, J. Yu, K. W. Kinzler, and B. Vogelstein. 1998. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95:2509-2514.
19. Hedley, S. J., M. A. uf der, S. Hohn, D. Escher, A. Barberis, J. N. Glasgow, J. T. Douglas, N. Korokhov, and D. T. Curiel. 2006. An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery. Gene Ther. 13:88-94.
20. Heise, C., A. Sampson-Johannes, A. Williams, F. McCormick, D. D. Von Hoff, and D. H. Kirn. 1997. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med. 3:639-645.
21. Henning, P., K. M. Andersson, K. Frykholm, A. Ali, M. K. Magnusson, P. A. Nygren, O. Granio, S. S. Hong, P. Boulanger, and L. Lindholm. 2005. Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains. Gene Ther. 12:211-224.
22. Henning, P., M. K. Magnusson, E. Gunneriusson, S. S. Hong, P. Boulanger, P. A. Nygren, and L. Lindbolm. 2002. Genetic modification of adenovirus 5 tropism by a novel class of ligands based on a three-helix bundle scaffold derived from staphylococcal protein A. Hum. Gene Ther. 13:1427-1439.
23. Hong, J. S., and J. A. Engler. 1996. Domains required for assembly of adenovirus type 2 fiber trimers. J. Virol. 70:7071-7078.
24. Hoppe, H. J., P. N. Barlow, and K. B. Reid. 1994. A parallel three stranded α-helical bundle at the nucleation site of collagen triple-helix formation. FEBS Lett. 344:191-195.
25. Khare, P. D., S.-X. Liao, M. Kuroki, Y. Hirose, F. Arakawa, K. Nakamura, Y. Tomita, and M. Kuroki. 2001. Specifically targeted killing of carcinoembryonic antigen (CEA)-expressing cells by a retroviral vector displaying single-chain variable fragmented antibody to CEA and carrying the gene for inducible nitric oxide synthase. Cancer Res 61:370-375.
26. Krasnykh, V., N. Belousova, N. Korokhov, G. Mikheeva, and D. T. Curiel. 2001. Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J. Virol. 75:4176-4183.
27. Krasnykh, V., I. Dmitriev, G. Mikheeva, C. R. Miller, N. Belousova, and D. T. Curiel. 1998. Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J. Virol. 72:1844-1852.
28. Krasnykh, V., I. Dmitriev, J. G. Navarro, N. Belousova, E. Kashentseva, J. Xiang, J. T. Douglas, and D. T. Curiel. 2000. Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity. Cancer Res. 60:6784-6787.
29. Kuroki, M., F. Arakawa, M. Haruno, M. Murakami, M. Wakisaka, H. Higuchi, S. Oikawa, H. Nakazato, and Y. Matsuoka. 1992. Biochemical characterization of 25 distinct carcinoembryonic antigen (CEA) epitopes recognized by 57 monoclonal antibodies and categorized into seven groups in terms of domain structure of the CEA molecule. Hybridoma 11:391-407.
30. Lemiale, F., W. P. Kong, L. M. Akyurek, X. Ling, Y. Huang, B. K. Chakrabarti, M. Eckhaus, and G. J. Nabel. 2003. Enhanced mucosal immunoglobulin A response of intranasal adenoviral vector human immunodeficiency virus vaccine and localization in the central nervous system. J. Virol. 77:10078-10087.
31. Letvin, N. L., Y. Huang, B. K. Chakrabarti, L. Xu, M. S. Seaman, K. Beaudry, B. Korioth-Schmitz, F. Yu, D. Rohne, K. L. Martin, A. Miura, W. P. Kong, Z. Y. Yang, R. S. Gelman, O. G. Golubeva, D. C. Montefiori, J. R. Mascola, and G. J. Nabel. 2004. Heterologous envelope immunogens contribute to AIDS vaccine protection in rhesus monkeys. J. Virol. 78:7490-7497.
32. Li, E., S. L. Brown, D. G. Stupack, X. S. Puente, D. A. Cheresh, and G. R. Nemerow. 2001. Integrin αvβ1 is an adenovirus coreceptor. J. Virol. 75:5405-5409.
33. Magnusson, M. K., S. S. Hong, P. Boulanger, and L. Lindholm. 2001. Genetic retargeting of adenovirus: novel strategy employing " deknobbing" of the fiber. J. Virol. 75:7280-7289.
34. Marshall, E. 2000. Gene therapy on trial. Science 288:951-957.
35. Michael, S. I., J. S. Hong, D. T. Curiel, and J. A. Engler. 1995. Addition of a short peptide ligand to the adenovirus fiber protein. Gene Ther. 2:660-668.
36. Mitraki, A., A. Barge, J. Chroboczek, J. P. Andrieu, J. Gagnon, and R. W. Ruigrok. 1999. Unfolding studies of human adenovirus type 2 fibre trimers. Evidence for a stable domain. Eur. J. Biochem. 264:599-606.
37. Morrison, K. B., C. E. Tognon, M. J. Garnett, C. Deal, and P. H. Sorensen. 2002. ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation. Oncogene 21:5684-5695.
38. Nibert, M. L., T. S. Dermody, and B. N. Fields. 1990. Structure of the reovirus cell-attachment protein: a model for the domain organization of σ1. J. Virol. 64:2976-2989.
39. Novelli, A., and P. A. Boulanger. 1991. Deletion analysis of functional domains in baculovirus-expressed adenovirus type 2 fiber. Virology 185:365-376.
40. Papanikolopoulou, K., V. Forge, P. Goeltz, and A. Mitraki. 2004. Formation of highly stable chimeric trimers by fusion of an adenovirus fiber shaft fragment with the foldon domain of bacteriophage T4 fibritin. J. Biol. Chem. 279:8991-8998.
41. Santis, G., V. Legrand, S. S. Hong, E. Davison, I. Kirby, J. L. Imler, R. W. Finberg, J. M. Bergelson, M. Mehtali, and P. Boulanger. 1999. Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR. J. Gen. Virol. 80:1519-1527.
42. Saukkonen, K., and A. Hemminki. 2004. Tissue-specific promoters for cancer gene therapy. Expert Opin. Biol. Ther. 4:683-696.
43. Shiver, J. W., and E. A. Emini. 2004. Recent advances in the development of HIV-1 vaccines using replication-incompetent adenovirus vectors. Annu. Rev. Med. 55:355-372.
44. Shiver, J. W., T. M. Fu, L. Chen, D. R. Casimiro, M. E. Davies, R. K. Evans, Z. Q. Zhang, A. J. Simon, W. L. Trigona, S. A. Dubey, L. Huang, V. A. Harris, R. S. Long, X. Liang, L. Handt, W. A. Schleif, L. Zhu, D. C. Freed, N. V. Persaud, L. Guan, K. S. Punt, A. Tang, M. Chen, K. A. Wilson, K. B. Collins, G. J. Heidecker, V. R. Fernandez, H. C. Perry, J. G. Joyce, K. M. Grimm, J. C. Cook, P. M. Keller, D. S. Kresock, H. Mach, R. D. Troutman, L. A. Isopi, D. M. Williams, Z. Xu, K. E. Bohannon, D. B. Volkin, D. C. Montefiori, A. Miura, G. R. Krivulka, M. A. Lifton, M. J. Kuroda, J. E. Schmitz, N. L. Letvin, M. J. Caulfield, A. J. Bett, R. Youil, D. C. Kaslow, and E. A. Emini. 2002. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature 415:331-335.
45. Tomko, R. P., R. Xu, and L. Philipson. 1997. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc. Natl. Acad. Sci. USA 94:3352-3356.
46. Valère, T. 1999. Gene transfer and therapy clinical trials - update. Part 2: gene delivery systems used and genes transferred. J. Gene Med. 1:151-153.
47. van Beusechem, V., A. L. van Rijswijk, H. H. van Es, H. J. Haisma, H. M. Pinedo, and W. R. Gerritsen. 2000. Recombinant adenovirus vectors with knobless fibers for targeted gene transfer. Gene Ther. 7:1940-1946.
48. van Raaij, M. J., A. Mitraki, G. La vigne, and S. Cusack. 1999. A triple β-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein. Nature 401:935-938.
49. Volpers, C., and S. Kochanek. 2004. Adenoviral vectors for gene transfer and therapy. J. Gene Med. 6(Suppl. 1):S164-S171.
50. Von Seggern, D. J., C. Y. Chiu, S. K. Fleck, P. L. Stewart, and G. R. Nemerow. 1999. A helper-independent adenovirus vector with E1, E3, and fiber deleted: structure and infectivity of fiberless particles. J. Virol. 73:1601-1608.
51. Von Seggern, D. J., S. Huang, S. K. Fleck, S. C. Stevenson, and G. R. Nemerow. 2000. Adenovirus vector pseudotyping in fiber-expressing cell lines: improved transduction of Epstein-Barr virus-transformed B cells. J. Virol. 74:354-362.
52. Wickham, T. J., P. Mathias, D. A. Cheresh, and G. R. Nemerow. 1993. Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment. Cell 73:309-319.
53. Wu, E., L. Pache, D. J. Von Seggern, T. M. Mullen, Y. Mikyas, P. L. Stewart, and G. R. Nemerow. 2003. Flexibility of the adenovirus fiber is required for efficient receptor interaction. J. Virol. 77:7225-7235.