Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 8, 2008, Pages 2652-2657

  Das, Jagabandhu ^a   Moquin, Robert V ^a   Pitt, Sidney ^a   Zhang, Rosemary ^a   Shen, Ding Ren ^a   McIntyre, Kim W ^a   Gillooly, Kathleen ^a   Doweyko, Arthur M ^a   Sack, John S ^a   Zhang, Hongjian ^a   Kiefer, Susan E ^a   Kish, Kevin ^a   McKinnon, Murray ^a   Barrish, Joel C ^a   Dodd, John H ^a   Schieven, Gary L ^a   Leftheris, Katerina ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

p38 inhibitors; Pyrazolo pyrimidines

Indexed keywords

HETEROCYCLIC COMPOUND; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 41849148990     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.019     Document Type: Article

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