Mucoadhesion, hydration and rheological properties of non-aqueous delivery systems (NADS) for the oral cavity

Journal of Dentistry

Volumn 36, Issue 5, 2008, Pages 351-359

  Zaman, Mustafa A ^a   Martin, Gary P ^a   Rees, Gareth D ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Hydration; Mucoadhesion; Non aqueous delivery systems (NADS); Rheology

Indexed keywords

ACRYLIC ACID DERIVATIVE; ADHESIVE AGENT; BIOMEDICAL AND DENTAL MATERIALS; CARBOPOL 974P NF; DRUG CARRIER; DRUG VEHICLE; GLYCEROL; MACROGOL DERIVATIVE; SALIVA SUBSTITUTE; SOLVENT; UNCLASSIFIED DRUG; WATER;

ADHESION; ANIMAL; ARTICLE; CHEMISTRY; DRUG DELIVERY SYSTEM; ELASTICITY; FLOW KINETICS; HUMAN; INTESTINE MUCOSA; MATERIALS TESTING; METABOLISM; METHODOLOGY; RAT; SALIVA; TENSILE STRENGTH; VEHICLES; VISCOSITY; WISTAR RAT;

ACRYLATES; ADHESIVENESS; ADHESIVES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ELASTICITY; GLYCEROL; HUMANS; INTESTINAL MUCOSA; MATERIALS TESTING; PHARMACEUTICAL PREPARATIONS, DENTAL; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; RHEOLOGY; SALIVA; SALIVA, ARTIFICIAL; SOLVENTS; TENSILE STRENGTH; VEHICLES; VISCOSITY; WATER;

EID: 41849139586     PISSN: 03005712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdent.2008.01.014     Document Type: Article

References (27)

1. Rathbone M.J., Drummond B.K., and Tucker I.J. The oral cavity as a site for drug delivery. Advanced Drug Delivery Reviews 13 (1994) 1-22
2. Chickering D.E., Jacob J.S., Desai T.A., Harrison M., Harris W.P., Morrell C.N., et al. Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres. Journal of Controlled Release 48 (1997) 35-46
3. Martin L., Wilson C.G., Koosha F., and Uchegbu I.F. Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels. European Journal of Pharmaceutics and Biopharmaceutics 55 (2003) 35-45
4. Mallery S.R., Stoner G.D., Larsen P.E., Fields H.W., Rodrigo K.A., Schwartz S.J., et al. Formulation and in vitro and in vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: Implications for oral cancer chemoprevention. Pharmaceutical Research 24 (2007) 728-737
5. Abdel-Hamid S.M., Abdel-Hady S.E., El-Shamy A.A., and El-Dessouky H.F. Formulation of an antispasmodic drug as a topical local anaesthetic. International Journal of Pharmaceutics 326 (2006) 107-118
6. Nair M.K., and Chein Y.W. Development of anticandidal delivery systems. (II) Mucoadhesive devices for prolonged drug delivery in the oral cavity. Drug Development and Industrial Pharmacy 22 (1996) 243-253
7. Cosyn J., and Sabzevar M.M. A systematic review of subgingival chlorhexidine gel administration in the treatment of chronic periodontitis. Journal of Periodontology 76 (2005) 1805-1813
8. Schiff T. Anticalculus effect of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel: results of a randomized, double blind, controlled clinical trial. Journal of Clinical Dentistry 18 (2007) 79-81
9. Smart J.D. Recent developments in the use of bioadhesive systems for delivery of drugs to the oral cavity. Critical Reviews in Therapeutic Drug Delivery Systems 21 (2004) 319-344
10. Bromberg L., Temchenko M., Alakhov V., and Hatton T.A. Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels. International Journal of Pharmaceutics 282 (2004) 45-60
11. Mortazavi S.A., and Smart J.D. An investigation into the role of water movement and mucus gel dehydration in mucoadhesion. Journal of Controlled Release 25 (1993) 197-203
12. Mortazavi S.A., and Smart J.D. An investigation of some factors influencing the in vitro assessment of mucoadhesion. International Journal of Pharmaceutics 116 (1995) 223-230
13. Wong C.F., Yuen K.H., and Peh K.K. Formulation and evaluation of controlled release Eudragit buccal devices. International Journal of Pharmaceutics 178 (1999) 11-22
14. Smart J.D. An in vitro assessment of some mucosa-adhesive dosage forms. International Journal of Pharmaceutics 73 (1991) 69-74
15. Huang Y., Leobandung W., Foss A., and Peppas N.A. Molecular aspects of muco- and bioadhesion: tethered structures and site-specific surfaces. Journal of Controlled Release 65 (2000) 63-71
16. De Ascentis A., de Grazia J.L., Bowman C.N., Colombo P., and Peppas NA. Mucoadhesion of poly(2-hydroxyethylmethacrylate) is improved when linear poly(ethylene oxide) chains are added to the polymer network. Journal of Controlled Release 33 (1995) 197-201
17. Wilson M., Kpendema H., Noar J.H., Hunt N., and Mordan N.J. Corrosion of intra-oral magnets in the presence and absence of biofilms of Streptococcus sanguis. Biomaterials 16 (1995) 721-725
18. Driesden G.M., Warren P.R., and Ernst C.P. A laboratory comparison of efficacy of two powered toothbrushes. Journal of Dental Research 79 (2000) S1233
19. Hefferren J.J., Coffman L., and Berg M.L. Functionality of toothbrush/toothpaste systems. Journal of Dental Research 79 (2000) S582
20. Needleman I.G., Martin G.P., and Smales F.C. Characterisation of bioadhesives for periodontal and oral mucosal drug delivery. Journal of Clinical Periodontology 25 (1998) 74-82
21. Wong C.F., Yuen K.H., and Peh K.K. An in vitro method for buccal adhesion studies: importance of instrument variables. International Journal of Pharmaceutics 180 (1999) 47-57
22. Shojaei A.H., Paulson J., and Honary S. Evaluation of poly(acrylic acid-co-ethylhexyl acrylate) films for mucoadhesive transbuccal drug delivery: factors affecting the force of mucoadhesion. Journal of Controlled Release 67 (2000) 223-232
23. Kockisch S., Rees G.D., Young S.A., Tsibouklis J., and Smart J.D. In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions. International Journal of Pharmaceutics 276 (2004) 51-58
24. Gu J.-M., Robinson J.R., and Leung S.-H. Binding of acrylic polymers to mucin/epithelial surfaces: structure-property relationships. CRC Critical Reviews in Therapeutic Drug Carrier Systems 5 (1998) 21-67
25. García-González N., Kellaway I.W., Blanco Fuente H., Anguiano Igea S., Delgado Charro B., Otero Espinar F.J., et al. Influence of glycerol concentration and Carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels. International Journal of Pharmaceutics 104 (1994) 107-113
26. García-González N., Kellaway I.W., Blanco Fuente H., Anguiano Igea S., DelgadoCharro B., Otero Espinar F.J., et al. Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose. International Journal of Pharmaceutics 100 (1993) 65-70
27. Ponchel G., Touchard F., Duchene D., and Peppas N.A. Bioadhesive analysis of controlled release systems. I. Fracture and interpenetration analysis in poly (acrylic acid)-contained systems. Journal of Controlled Release 5 (1987) 129-141