Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells

Biochemical and Biophysical Research Communications

Volumn 370, Issue 1, 2008, Pages 123-128

  Hara, Shingo ^a,b   Nakashiro, Koh ichi ^a   Goda, Hiroyuki ^a   Hamakawa, Hiroyuki ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NONE   (Japan)

Author keywords

Akt; HGF; Invasive growth; RNAi; Salivary gland cancer

Indexed keywords

AKT 3 PROTEIN; GREEN FLUORESCENT PROTEIN; ISOPROTEIN; PROTEIN KINASE B; PROTEIN KINASE B BETA; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ADENOID CYSTIC CARCINOMA; ARTICLE; CANCER GROWTH; CANCER INVASION; CELL TYPE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SALIVARY GLAND CANCER; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BASE SEQUENCE; CARCINOMA, ADENOID CYSTIC; HEPATOCYTE GROWTH FACTOR; HUMANS; ISOENZYMES; NEOPLASM INVASIVENESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MET; RNA, SMALL INTERFERING; SALIVARY GLAND NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 41849136466     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.03.042     Document Type: Article

References (20)

1. Hotte S.J., Winquist E.W., Lamont E., MacKenzie M., Vokes E., Chen E.X., Brown S., Pond G.R., Murgo A., and Siu L.L. Imatinib mesylate in patients with adenoid cystic carcinoma of the salivary gland expressing c-kit: a Princess Margaret Hospital Phase α consortium study. J. Clin. Oncol. 23 3 (2005) 585-590
2. Meldrum M.L., Tse D.T., and Benedetto P. Neoadjuvant intracarotid chemotherapy for treatment of advanced adenocystic carcinoma of the lacrimal gland. Arch. Ophthalmol. 116 (1998) 315-321
3. Nakamura T., Teramoto H., and Ichihara A. Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures. Proc. Natl. Acad. Sci. USA 83 (1986) 6489-6493
4. Suzuki K., Cheng J., and Watanabe Y. Hepatocyte growth factor and c-Met (HGF/c-Met) in adenoid cystic carcinoma of the human salivary gland. J. Oral. Pathol. Med. 32 32 (2003) 84-89
5. Nakashiro K., Okamoto M., Hayashi Y., and Oyasu R. Hepatocyte growth factor secreted by prostate-derived stromal cells stimulates growth of androgen-independent human prostatic carcinoma cells. Am. J. Pathol. 157 3 (2000) 795-803
6. Vivanco I., and Sawyers C.L. The phosphatitidylinositol 3 kinase Akt pathway in human cancer. Nat. Rev. Cancer 2 (2002) 489-501
7. Bridge A.J., Pebernard S., Ducraux A., Nicoulaz A.L., and Iggo R. Induction of an interferon response by RNAi vectors in mammalian cells. Nat. Genet. 34 3 (2003) 263-264
8. Sonnenberg E., Meyer D., Weidner K.M., and Birchmeier C. Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J. Cell Biol. 123 (1993) 223-225
9. Kawaida K., Matsumoto K., Shimazu H., and Nakamura T. Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice. Proc. Natl. Acad. Sci. USA 91 (1994) 4357-4361
10. Fruman D.A., Snapper S.B., Yballe C.M., Davidson L., Yu J.Y., Alt F.W., and Cantley L.C. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 283 (1999) 393-397
11. Inukai K., Funaki M., Ogihara T., Katagiri H., Kanda A., Anai M., Fukushima Y., Hosaka T., Suzuki M., Shin B.C., Takata K., Yazaki Y., et al. p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI3-kinase), p50α, p55α, and p85α, with different PI3-kinase activity elevating responses to insulin. J. Biol. Chem. 272 (1997) 7873-7882
12. Bellacosa A., de Feo D., Godwin A.K., Bell D.W., Cheng J.Q., Altomare D.A., Wan M., Dubeau L., Scambia G., Masciullo V., Ferrandina G., Benedetti Panici P., et al. Molecular alterations of the Akt2 oncogene in ovarian and breast carcinomas. Int. J. Cancer 64 4 (1995) 280-285
13. Konishi H., Shinomura T., Kuroda S., Ono Y., and Kikkawa U. Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta. Biochem. Biophys. Res. Commun. 205 1 (1994) 817-825
14. Nakatani K., Sakaue H., Thompson D.A., Weigel R.J., and Roth R.A. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. Biochem. Biophys. Res. Commun. 257 3 (1999) 906-910
15. Edwards J., Krishna N.S., Witton C.J., and Bartlett J.M. Gene amplification is associated with the development of hormone resistant prostatic cancer. Clin. Cancer Res. 9 (2003) 5271-5281
16. Chen W.S., Xu P.Z., Gottlob K., Chen M.L., Sokol K., Shiyanova T., Roninson I., Weng W., Suzuki R., Tobe K., Kadowaki T., and Hay N. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15 (2001) 2203-2208
17. Garofalo R.S., Orena S.J., Rafidi K., Torchia A.J., Stock J.L., Hildebrandt A.L., Coskran T., Black S.C., Brees D.J., Wicks J.R., McNeish J.D., and Coleman K.G. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J. Clin. Invest. 112 (2003) 197-208
18. Tschopp O., Yang Z.Z., Brodbeck D., Dummler B.A., Hemmings-Mieszczak M., Watanabe T., Michaelis T., Frahm J., and Hemmings B.A. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132 (2005) 2943-2954
19. Peng X.D., Xu P.Z., Chen M.L., Hahn-Windgassen A., Skeen J., Jacobs J., Sundararajan D., Chen W.S., Crawford S.E., Coleman K.G., and Hay N. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev. 17 (2003) 1352-1365
20. Yang Z.Z., Tschopp O., Di-Poï N., Bruder E., Baudry A., Dümmler B., Wahli W., and Hemmings B.A. Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice. Mol. Cell Biol. 25 (2005) 10407-10418