Selective vasodilatation effect of sargahydroquinoic acid, an active constituent of Sargassum micracanthum, on the basilar arteries of rabbits

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 8, 2008, Pages 2624-2627

  Park, Byong Gon ^a   Shin, Woon Seob ^a   Um, Yumi ^a   Cho, Sungsik ^a   Park, Gab Man ^a   Yeon, Dong Soo ^a   Kwon, Seong Chun ^a   Ham, Jungyeob ^b   Choi, Byoung Wook ^c   Lee, Seokjoon ^a  

^a Catholic Kwandong University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Hanbat National University   (South Korea)

Author keywords

Basilar artery; Cerebrovascular diseases; Natural product; Sargahydroquinoic acid; Vasodilatation

Indexed keywords

SARGAHYDROQUINOIC ACID; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BASILAR ARTERY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PROTECTION; BRAIN VASOSPASM; CEREBRAL ARTERY DISEASE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG SELECTIVITY; DRUG STRUCTURE; KOREA; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; RABBIT; SARGASSUM; SARGASSUM MICRACANTHUM; SUBARACHNOID HEMORRHAGE; VASODILATATION;

ALKENES; ANIMALS; BASILAR ARTERY; BENZOQUINONES; MOLECULAR STRUCTURE; RABBITS; SARGASSUM; VASODILATION;

ORYCTOLAGUS CUNICULUS; SARGASSUM MICRACANTHUM;

EID: 41849126417     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.034     Document Type: Article

References (36)

1. Balunas M.J., and Kinghorn A.D. Life Sci. 78 (2005) 431
2. Haefner B. Drug Discov. Today 8 (2003) 536
3. Mayer A.M.S., Rodri{dotless}́guez A.D., Berlinck R.G.S., and Hamann M.T. Comp. Biochem. Physiol. C: Pharmacol. Toxicol. 145 (2007) 553
4. Miller A.A., Drummond G.R., and Sobey C.G. Drug Discov. Today: Ther. Strateg. 2 (2005) 187
5. Kearney P.M., Whelton M., Reynolds K., Muntner P., Whelton P.K., and He J. Lancet 365 (2005) 217
6. Karaki H., and Weiss G.B. Life Sci. 42 (1988) 111
7. Karaki H., Ozaki J., Hori M., Mitsui-Saito M., Amano K., Harada K., Miyamoto S., Nakazawa H., Won K.J., and Sato K. Pharmacol. Rev. 49 (1997) 157
8. Shaw M.D., Vermeulen M., Murray G.D., Pickard J.D., Bell B.A., and Teasdale G.M. J. Neurosurg. 93 (2000) 992
9. Zuccarello M., Boccaletti R., Tosun M., and Rapoport R.M. Stroke 27 (1996) 1896
10. Kasuya H., Onda H., Takeshita M., Okada Y., and Hori T. Stroke 33 (2002) 1011
11. Pasqualin A., Vollmer D.G., Marron J.A., Tsukahara T., Kassell N.F., and Torner J.C. Neurosurgery 29 (1991) 183
12. The brown alga, Sargassum micracanthum, was collected at the Jangho harbor, Gangwon, South Korea, in February 2005, at a depth of 2-3 m. The voucher for specimen (sample No. MNP-O-20) is deposited at the Marine Biomedical Research Center, Kwandong University College of Medicine, Gangwon, South Korea, under supervision of professor Gab-Man Park.
13. Kusumi T., Shibata Y., Ishitsuka M., Kinoshita T., and Kakisawa H. Chem. Lett. (1979) 277
14. Kikuchi T., Mori Y., Yokoi T., Nakazawa S., Kuroda H., Masada Y., Kitamura K., and Kuriyama K. Chem. Pharm. Bull. 31 (1983) 106
15. Ishitsuka M., Kusumi T., Nomura Y., Konno T., and Kakisawa H. Chem. Lett. (1979) 1269
16. Pérez-Castorena A.L., Arciniegas A., Apan M.T.R., Villaseñor J.L., and de Vivar A.R. Planta Med. 68 (2002) 645
17. Nakayama M., Fukuoka Y., Nozaki H., Matsuo A., and Hayashi S. Chem. Lett. (1980) 1243
18. Hoshino T., Hayashi T., Hayashi K., Hamada J., Lee J.B., and Sankawa U. Biol. Pharm. Chem. 21 (1998) 730
19. Iwashima M., Mori J., Ting S., Matsunaga T., Hayashi K., Shinoda D., Saito H., Sanakawa U., and Hayashi T. Biol. Pharm. Bull. 28 (2005) 374
20. Hayashi K., Mori J., Saito H., and Hayashi T. Biol. Pharm. Bull. 29 (2006) 1743
21. Mori J., Hayashi T., Iwashima M., Matsunaga T., and Saito H. Biol. Pharm. Bull. 29 (2006) 1197
22. Komai E., Miyahara T., Mori J., Obi N., Ochiai H., Saito H., and Hayashi T. Biol. Pharm. Bull. 29 (2006) 1980
23. Iwata S., Saito S.Y., Kon-ya K., Shizuri Y., and Ohizumi Y. Eur. J. Pharmacol. 432 (2001) 63
24. 3) δ 188.1, 188.0, 173.0, 148.5, 145.9, 145.5, 139.8, 134.6, 133.2, 132.3, 130.6, 124.5, 123.5, 118.0, 39.6, 39.1, 34.6, 28.2, 27.9, 27.6, 26.4, 25.7, 17.7, 16.1, 16.0, 15.9 ppm.
25. 3) δ 173.1, 148.9, 146.6, 145.8, 138.5, 134.9, 132.5, 130.8, 127.9, 125.8, 124.5, 123.7, 121.9, 115.7, 114.2, 39.7, 39.2, 34.7, 30.1, 28.5, 28.1, 26.3, 25.9, 17.9, 16.4, 16.3, 16.2 ppm.
26. Segawa M., and Shirahama H. Chem. Lett. (1987) 1365
27. Silva D.H.S., Zhang Y., Santos L.A., Bolzani V.S., and Nair M.G. J. Agric. Food Chem. 55 (2007) 2569
28. Choi B.W., Ryu G., Park S.H., Kim E.S., Shin J., Roh S.S., Shin H.C., and Lee B.H. Phytother. Res. 21 (2007) 423
29. Ysang C.K., and Kamei Y. Eur. J. Pharmacol. 488 (2004) 11
30. Céspedes C.L., Torres P., Mari{dotless}́n J.C., Arciniegas A., de Vivar A.R., Pérez-Castorena A.L., and Aranda E. Phytochemistry 65 (2004) 1963
31. Komuro T., Miwa S., Zhang X.F., Minowa T., Enoki T., Kobayashi S., Okamoto Y., Ninomiya H., Sawamura T., Kikuta K., Iwamuro Y., Furutani H., Hasegawa H., Uemura Y., Kikuchi H., and Masaki T. J. Cardiovasc. Pharmacol. 30 (1997) 504
32. Zhang X.F., Iwamuro Y., Enoki T., Okazawa M., Lee K., Komuro T., Minowa T., Okamoto Y., Hasegawa H., Furutani H., Miwa S., and Masaki T.Br. J. Pharmacol. 127 (1999) 1388
33. + reached a steady-state on the basilar artery and with cumulative application on the carotid artery.
34. Mori J., Iwashima M., Wakasugi H., Saito H., Matsunaga T., Ogasawara M., Takahashi S., Suzuki H., and Hayashi T. Chem. Pharm. Bull. 53 (2005) 1159
35. Iwashima M., Mori J., Ting X., Matsunaga T., Hayashi K., Shinoda D., Saito H., Sankawa U., and Hayashi T. Biol. Pharm. Bull. 28 (2005) 374
36. Malnoey D.J., and Hecht S.M. Org. Lett. 7 (2005) 4297