Novel marine-derived halogen-containing gramine analogues induce vasorelaxation in isolated rat aorta

European Journal of Pharmacology

Volumn 432, Issue 1, 2001, Pages 63-70

  Iwata, Shingo ^a   Saito, Shin Ya ^a   Kon ya, Kazumi ^b   Shizuri, Yoshikazu ^b   Ohizumi, Yasushi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b MARINE BIOTECHNOLOGY INSTITUTE   (Japan)

Author keywords

Aorta; Ca2+ channel blocker; cAMP; Gramine analogue; Marine natural product; Rat

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2,5,6 TRIBROMO 1 METHYLGRAMINE; 5,6 DIBROMO 1,2 DIMETHYLGRAMINE; CAFFEINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CYCLIC AMP; GRAMINE; INDOLE DERIVATIVE; MANGANESE; PHENYLEPHRINE; POTASSIUM ION; UNCLASSIFIED DRUG;

ANIMAL TISSUE; AORTA CONSTRICTION; AORTA MEDIA; ARTICLE; BRYOZOA; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; MALE; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; THORACIC AORTA; VASODILATATION;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ALKALOIDS; ANIMALS; AORTA, THORACIC; CAFFEINE; CALCIUM; CALCIUM CHANNEL AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; ISOQUINOLINES; MALE; PHENYLEPHRINE; POTASSIUM; RATS; RATS, WISTAR; SULFONAMIDES; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION;

EID: 0035976838     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01476-5     Document Type: Article

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