Nucleus accumbens activation mediates the influence of reward cues on financial risk taking

NeuroReport

Volumn 19, Issue 5, 2008, Pages 509-513

  Knutson, Brian ^a   Wimmer, G Elliott ^a   Kuhnen, Camelia M ^c   Winkielman, Piotr ^b  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Accumbens; Cue; Decision; Financial; Functional magnetic resonance imaging; Human; Reward; Risk; Striatum

Indexed keywords

ADULT; ARTICLE; ASSOCIATION; BRAIN DEPTH STIMULATION; CORPUS STRIATUM; EMOTION; EVENT RELATED POTENTIAL; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HETEROSEXUAL MALE; HIGH RISK BEHAVIOR; HUMAN; HUMAN EXPERIMENT; MALE; MEDICAL RESEARCH; NEUROPSYCHOLOGY; NORMAL HUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; REWARD;

ADOLESCENT; ADULT; BRAIN MAPPING; CUES; ECONOMICS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NUCLEUS ACCUMBENS; OXYGEN; REGRESSION ANALYSIS; REWARD; RISK-TAKING;

EID: 41849092173     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e3282f85c01     Document Type: Article

References (22)

1. Loewenstein GF, Weber EU, Hsee CK, Welch N. Risk as feelings. Psychol Bull 2001; 2:267-286.
2. Knutson B, Adams CM, Fong GW, Hommer D. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci 2001; 21:RC159.
3. Bechara A, Tranel D, Damasio H, Damasio AR. Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex. Cereb Cortex 1996; 6:215-225.
4. Preuschoff K, Bossaerts P, Quartz SR. Neural differentiation of expected reward and risk in human subcortical structures. Neuron 2006; 51:381-390.
5. Hamann S, Herman RA, Nolan CL, Wallen K. Men and women differ in amygdala response to visual sexual stimuli. Nat Neurosci 2004; 7:411-416.
6. Sabatinelli D, Bradley MM, Lang PJ, Costa VD, Versace R. Pleasure rather than salience activates human nucleus accumbens. J Neurophysiol 2007; 98:1374-1379.
7. Kuhnen CM, Knutson B. The neural basis of financial risk-taking. Neuron 2005; 47:763-770.
8. Nitschke JB, Sarinopoulos I, Mackiewicz KL, Schaefer HS, Davidson RJ. Functional anatomy of aversion and its anticipation. NeuroImage 2006; 29:106-116.
9. Wager TD, Phan KL, Liberzon I, Taylor SF. Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging. NeuroImage 2003; 19:513-531.
10. Markowitz H. Portfolio selection. J Finance 1952; 7:77-91.
11. Knutson B, Taylor J, Kaufman M, Peterson R, Glover G. Distributed neural representation of expected value. J Neurosci 2005; 25:4806-4812.
12. Glover GH, Law CS. Spiral-in/out BOLD fMRI for increased SNR and reduced susceptibility artifacts. Magn Reson Med 2001; 46:515-522.
13. Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance images. Comput Biomed Res 1996; 29:162-173.
14. Zarahn E. Testing for neural responses during temporal components of trials with BOLD fMRI. NeuroImage 2000; 11:783-796.
15. Knutson B, Fong GW, Bennett SM, Adams CM, Hommer D. A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related FMRI. NeuroImage 2003; 18:263-272.
16. Knutson B, Rick S, Wimmer GE, Prelec D, Loewenstein G. Neural predictors of purchases. Neuron 2007; 53:147-156.
17. Preacher KJ, Hayes AF. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav Res Methods Instrum Comput 2004; 36:717-731.
18. Hampton AN, O'Doherty JP. Decoding the neural substrates of reward-related decision making with functional MRI. Proc Natl Acad Sci 2007; 104:1377-1382.
19. Cohen MX, Ranganath C. Behavioral and neural predictors of upcoming decisions. Cogn Affect Behav Neurosci 2005; 5:117-126.
20. Matthews SC, Simmons AN, Lane SD, Paulus MP. Selective activation of the nucleus accumbens during risk-taking decision making. NeuroReport 2004; 15:2123-2127.
21. Robbins TW, Everitt BJ. Neurobehavioral mechanisms of reward and motivation. Curr Opin Neurobiol 1996; 6:228-236.
22. Knutson B, Bossaerts P. Neural antecedents of financial decisions. J Neurosci 2007; 27:8174-8177.