Cyclooxygenase products sensitize muscle mechanoreceptors in humans with heart failure

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 4, 2008, Pages

  Middlekauff, Holly R ^a   Chiu, Josephine ^a   Hamilton, Michele A ^a   Fonarow, Gregg C ^a   MacLellan, W Robb ^a   Hage, Antoine ^a   Moriguchi, Jaime ^a   Patel, Jignesh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Exercise; Sympathetic nerve activity

Indexed keywords

ADENOSINE; ADENOSINE RECEPTOR; AMINOPHYLLINE; INDOMETACIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE;

ADRENERGIC STIMULATION; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; HAND GRIP; HEART FAILURE; HUMAN; MALE; MECHANICAL STIMULATION; MECHANORECEPTOR; NEUROGRAPHY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SENSITIZATION; SYMPATHETIC NERVE;

ADENOSINE; ADULT; AMINOPHYLLINE; BLOOD PRESSURE; CYCLOOXYGENASE INHIBITORS; DOUBLE-BLIND METHOD; FEMALE; HAND STRENGTH; HEART FAILURE; HEART RATE; HUMANS; INDOMETHACIN; INFUSIONS, INTRAVENOUS; MALE; MECHANORECEPTORS; MECHANOTRANSDUCTION, CELLULAR; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE, SKELETAL; PERONEAL NERVE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, PURINERGIC P1; REFLEX; RESEARCH DESIGN; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS;

EID: 41749103569     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01304.2007     Document Type: Article

References (36)

1. Adreani CM, Kaufman MP. Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. J Appl Physiol 83: 1811-1817, 1998.
2. Alam M, Smirk FH. Observation in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol 89: 372-383, 1937.
3. Batman BA, Hardy JC, Leuenberger UA, Smith MA, Yang QX, Sinoway LI. Sympathetic nerve activity during prolonged rhythmic forearm exercise. J Appl Physiol 76: 1077-1081, 1994.
4. Clark AL, Poole-Wilson PA. Exercise limitation in chronic heart failure: central role of the periphery. J Am Coll Cardiol 28: 1092-1102, 1996.
5. Costa F, Biaggioni I. Role of adenosine in the sympathetic activation produced by isometric exercise in humans. J Clin Invest 93: 1654-1660, 1994.
6. Cui J, McQuillan P, Momen A, Blaha C, Moradkhan R, Mascarenhas V, Hogeman C, Krishnan A, Sinoway LI. The role of the cyclooxygenase products in evoking sympathetic activation in exercise. Am J Physiol Heart Circ Physiol 293: H1861-H1868, 2007.
7. Delius W, Hagbarth KE, Hongell A, Wallin BG. Manoeuvres affecting sympathetic outflow in human muscle nerves. Acta Physiol Scand 84: 82-94, 1972.
8. Franciosa JA, Park M, Levine TB. Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol 47: 33-39, 1981.
9. Grassi G, Mancia L. Sympathetic overactivity and exercise intolerance in heart failure: a cause-effect relationship. Eur Heart J 20: 854-855, 1999.
10. Hellsten Y, Maclean D, Radegran G, Saltin B, Bangsbo J. Adenosine concentrations in the interstitium of resting and contracting human skeletal muscle. Circulation 98: 6-8, 1998.
11. Herr MD, Imadojemu V, Kunselman AR, Sinoway LI. Characteristics of the muscle mechanoreflex during quadriceps contractions in humans. J Appl Physiol 86: 767-772, 1999.
12. Kaufman MP, Longhurst JC, Rybicki KJ, Wallach JH, Mitchell JH. Effects of static muscular contraction on impulse activity of groups III and IV afferents in cats. J Appl Physiol 55: 105-112, 1983.
13. Kaufman MP, Rybicki KJ, Waldrop TG, Ordway GA. Effect of ischemia on responses of group III and IV afferents to contraction. J Appl Physiol 57: 644-650, 1984.
14. Kaufman MP, Hayes SG. The exercise pressor reflex. Clin Auton Res 12: 429-439, 2002.
15. Mark AL, Victor RG, Nerhed C, Wallin BG. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57: 461-469, 1985.
16. McClain J, Hardy C, Enders B, Smith M, Sinoway L. Limb congestion and sympathoexcitation during exercise: implications for congestive heart failure. J Clin Invest 92: 2353-2359, 1993.
17. Middlekauff HR, Sontz EM. Morning sympathetic nerve activity is not increased in humans: implications for mechanisms underlying the circadian pattern of cardiac risk. Circulation 91: 2549-2555, 1995.
18. Middlekauff HR, Nitzsche EU, Hoh CK, Hamilton MA, Fonarow GC, Hage A, Moriguchi JD. Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure. J Appl Physiol 90: 1714-1719, 2001.
19. Middlekauff HR, Chui J, Hamilton MA, Fonarow GC, MacLellan WR, Hage A, Moriguchi JD, Patel J. Muscle mechanoreceptor sensitivity in heart failure. Am J Physiol Heart Circ Physiol 287: H1937-H1943, 2004.
20. Middlekauff HR, Chui J. Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans. Am J Physiol Heart Circ Physiol 287: H1944-H1949, 2004.
21. Notarius CF, Atchison DJ, Rongen GA, Floras JS. Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure. Am J Physiol Heart Circ Physiol 281: H1312-H1318, 2001.
22. Piepoli M, Clark AL, Volterrani M, Adamopoulos S, Sleight P, Coats AJS. Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training. Circulation 93: 940-952, 1996.
23. Piepoli M, Ponikowski P, Clark AL, Banasiak W, Capucci A, Coats AJS. A neural link to explain the "muscle hypothesis" of exercise intolerance in chronic heart failure. Am Heart J 137: 1050-1056, 1999.
24. Scott AC, Francis DP, Davies LC, Ponikowski P, Coats AJ, Piepoli MF. Contribution of skeletal muscle 'ergoreceptors' in the human respiratory control in chronic heart failure. J Physiol 529: 863-870, 2000.
25. Scott AC, Wensel R, Davos CH, Kemp M, KacZmarek A, Hooper J, Coats AJ, Piepoli MF. Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control. Circulation 106: 214-220, 2002.
26. Scott AC, Wensel R, Davos CH, Georgiadou P, Davies LC, Coats AJS, Francis DP, Piepoli MF. Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on Ace-inhibitor therapy for chronic heart failure. Eur Heart J 25: 1806-1813, 2004.
27. Seals DR, Victor RG. Regulation of muscle sympathetic nerve activity during exercise in humans. Exerc Sport Sci Rev 19: 313-349, 1991.
28. Sinoway LI, Hill JM, Pickar JG, Kaufman MP. Effects of contraction and lactic acid on the discharge of group III muscle afferents in cats. J Neurophysiol 69: 1053-1059, 1993.
29. Smith SA, Mammen PPA, Mitchell JH, Garry MG. Role of the exercise pressor reflex in rats with dilated cardiomyopathy. Circulation 108: 1126-1132, 2003.
30. Stebbins CL, Maruoka Y, Longhurst JC. Prostaglandins contribute to cardiovascular reflexes evoked by static muscular contraction. Circ Res 59: 645-654, 1986.
31. Sterns DA, Ettinger SM, Gray KS, Whisler SK, Mosher TJ, Smith MB, Sinoway LI. Skeletal muscle metaboreceptor exercise responses are attenuated in heart failure. Circulation 84: 2034-2039, 1991.
32. Vallbo AB, Hagbarth KE, Torebjork HE, Wallin BG. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Rev 59: 919-957, 1979.
33. Victor RG, Pryor SL, Secher NH, Mitchell JH. Effects of partial neuromuscular blockade on sympathetic nerve responses to static exercise in humans. Circ Res 65: 468-476, 1989.
34. Wilson JR, Kapoor SC. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am J Physiol Heart Circ Physiol 265: H171-H175, 1993.
35. Wilson JR, Rayos G, Yeoh TK, Gothard P, Bak K. Dissociation between exertional symptoms and circulatory function in patients with HF. Circulation 92: 47-53, 1995.
36. Wilson JR, Rayos G, Yeoh TK, Gothard P. Dissociation between peak exercise oxygen consumption and hemodynamic dysfunction in potential heart transplant candidates. J Am Coll Cardiol 26: 429 - 435, 1995.