CreA-mediated repression in Aspergillus nidulans does not require transcriptional auto-regulation, regulated intracellular localisation or degradation of CreA

Fungal Genetics and Biology

Volumn 45, Issue 5, 2008, Pages 657-670

  Roy, Preeti ^a   Lockington, Robin A ^a   Kelly, Joan M ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

AcrB; Aspergillus nidulans; CreB deubiquitinating enzyme; CreC; CreD; Filamentous fungi; Gene regulation in filamentous fungi; Transcriptional repressor

Indexed keywords

ACRB PROTEIN; CREA PROTEIN; CRED PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GENE PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS NIDULANS; AUTOREGULATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; GENE CONTROL; GENE LOCATION; GENE REPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ASCOMYCOTA; ASPERGILLUS NIDULANS; BLOTTING, WESTERN; CARBON; CELL NUCLEUS; CYTOPLASM; DNA MUTATIONAL ANALYSIS; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MUTATION; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRICHODERMA;

EMERICELLA NIDULANS; FUNGI; HYPOCREA JECORINA; SCLEROTINA;

EID: 41649119728     PISSN: 10871845     EISSN: 10960937     Source Type: Journal    
DOI: 10.1016/j.fgb.2007.10.016     Document Type: Article

References (47)

1. Ahuatzi D., Herrero P., de la Cera T., and Moreno F. The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent. Journal of Biological Chemistry 279 (2004) 14440-14446
2. Ahuatzi D., Riera A., Pelaez R., Herrero P., and Moreno F. Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. Journal of Biological Chemistry 282 (2007) 4485-4493
3. Arst H.N., and Cove D.J. Nitrogen metabolite repression in Aspergillus nidulans. Molecular and General Genetics 126 (1973) 111-141
4. Arst H.N., Tollervey D., Dowzer C.E., and Kelly J.M. An inversion truncating the creA gene of Aspergillus nidulans results in carbon catabolite derepression. Molecular Microbiology 4 (1990) 851-854
5. Bailey C., and Arst H.N. Carbon catabolite repression in Aspergillus nidulans. European Journal of Biochemistry 51 (1975) 575-577
6. Barral Y., Jentsch S., and Mann C. G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast. Genes and Development 9 (1995) 399-409
7. Boase N.A., and Kelly J.M. A role for creD, a carbon catabolite repression gene from Aspergillus nidulans, in ubiquitination. Molecular Microbiology 53 (2004) 929-940
8. Boase N.A., Lockington R.A., Adams J.R.J., Rodbourn L., and Kelly J.M. Molecular characterization and analysis of the acrB gene of Aspergillus nidulans: a gene identified by genetic interaction as a component of the regulatory network that includes the CreB deubiquitination enzyme. Genetics 164 (2003) 95-104
9. Cokol M., Nair R., and Rost B. Finding nuclear localization signals. EMBO Reports 1 (2000) 411-415
10. Cubero B., and Scazzocchio C. Two different, adjacent and divergent zinc finger binding sites are necessary for CreA mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans. EMBO Journal 13 (1994) 407-415
11. Cubero B., Gomez D., and Scazzocchio C. Metabolite repression and inducer exclusion in the proline utilization gene cluster of Aspergillus nidulans. Journal of Bacteriology 182 (2000) 233-235
12. Cziferszky A., Mach R.L., and Kubicek C.P. Phosphorylation positively regulates DNA binding of the carbon catabolite repressor Cre1 of Hypocrea jecorina (Trichoderma reesei). Journal of Biological Chemistry 277 (2002) 14688-14694
13. de Rue J.L., Tokarz S., and Lanker S. SCFGrr1-mediated ubiquitination of Gis4 modulates glucose response in yeast. Journal of Molecular Biology 349 (2005) 685-698
14. De Vit M., and Johnston M. The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae. Current Biology 9 (1999) 1231-1241
15. De Vit M.J., Waddle J.A., and Johnston M. Regulated nuclear translocation of the Mig1 glucose repressor. Molecular Biology of the Cell 8 (1997) 1603-1618
16. Dowzer C.E.A., and Kelly J.M. Cloning of creA from Aspergillus nidulans: a gene involved in carbon catabolite repression. Current Genetics 15 (1989) 457-459
17. Dowzer C.E.A., and Kelly J.M. Analysis of the creA gene, a regulator of carbon catabolite repression in Aspergillus nidulans. Molecular and Cellular Biology 11 (1991) 5701-5709
18. Drysdale M.R., Lockington R.A., and Kelly J.M. The Aspergillus niger carbon catabolite repressor encoding gene, creA. Gene 130 (1993) 241-245
19. Flipphi M., van de Vondervoort P.J.I., Ruijter G.J.G., Visser J., Arst H.N., and Felenbok A. Onset of carbon catabolite repression in Aspergillus nidulans-parallel involvement of hexokinase and glucokinase in sugar signaling. Journal of Biological Chemistry 278 (2003) 11849-11857
20. Hicks J., Lockington R.A., Strauss J., Dieringer D., Kubicek C.P., Kelly J., and Keller N. RcoA has pleiotropic effects on Aspergillus nidulans cellular development. Molecular Microbiology 39 (2001) 1482-1493
21. Hynes M.J., and Kelly J.M. Pleiotropic mutants of Aspergillus nidulans altered in carbon metabolism. Molecular and General Genetics 150 (1977) 193-204
22. Ilmen M., Thrane C., and Penttila M. The glucose repressor gene cre1 of Trichoderma: isolation and expression of a full-length and a truncated mutant form. Molecular and General Genetics 253 (1996) 303-314
23. Jekosch K., and Kuck U. Loss of glucose repression in an Acremonium chrysogenum beta-lactam producer strain and its restoration by multiple copies of the cre1 gene. Applied Microbiology and Biotechnology (2000) 556-563
24. Jekosch K., and Kuck U. Glucose dependent transcriptional expression of the cre1 gene in Acremonium chrysogenum strains showing different levels of cephalosporin C production. Current Genetics (2000) 37
25. Kelly J.M., and Hynes M.J. Increased and decreased sensitivity to carbon catabolite repression of enzymes of acetate metabolism in mutants of Aspergillus nidulans. Molecular and General Genetics 156 (1977) 87-92
26. Kulmberg P., Mathieu M., Dowzer C.E.A., Kelly J.M., and Felenbok B. Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CreA repressor mediating carbon catabolite repression in Aspergillus nidulans. Molecular Microbiology 7 (1993) 847-857
27. Lockington R.A., and Kelly J.M. Carbon catabolite repression in Aspergillus nidulans involves deubiquitination. Molecular Microbiology 40 (2001) 1311-1321
28. Lockington R.A., and Kelly J.M. The WD40-repeat protein CreC interacts with and stabilizes the deubiquitinating enzyme CreB in vivo in Aspergillus nidulans. Molecular Microbiology 43 (2002) 1173-1182
29. Mathieu M., and Felenbok B. The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR-specific transactivator. EMBO Journal 13 (1994) 4022-4027
30. Moreno F., Ahuatzi D., Riera A., Palomino C.A., and Herrero P. Glucose sensing through the Hxk2-dependent signalling pathway. Biochemical Society Transactions 33 (2005) 265-268
31. Nehlin J.O., and Ronne H. Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO Journal 9 (1990) 2891-2898
32. Nehlin J.O., Carlberg M., and Ronne H. Control of yeast GAL genes by MIG1 repressor: A transcriptional cascade in the glucose response. EMBO Journal 10 (1991) 3373-3377
33. Ozcan S., Leong T., and Johnston M. Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Molecular and Cellular Biology 16 (1996) 6419-6426
34. Panozzo C., Cornillot E., and Felenbok B. The CreA repressor is the sole DNA-binding protein responsible for carbon catabolite repression of the alcA gene in Aspergillus nidulans via its binding to a couple of specific sites. Journal of Biological Chemistry 273 (1998) 6367-6372
35. Papamichos-Chronakis M., Gligoris T., and Tzamarias D. The Snf1 kinase controls glucose repression in yeast by modulating interactions between the Mig1 repressor and the Cyc8-Tupl co-repressor. EMBO Reports 5 (2004) 368-372
36. Papamichos-Chronakis M., Petrakis T., Ktistaki E., Topalidou I., and Tzamarias D. Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1. Molecular Cell 9 (2002) 1297-1305
37. Punt P.J., Dingemanse M.A., Kuyvenhoven A., Soede R.D., Pouwels P.H., and van den Hondel C.A. Functional elements in the promoter region of the Aspergillus nidulans gpdA gene encoding glyceraldehyde-3-phosphate dehydrogenase. Gene 93 (1990) 101-109
38. Shroff, R.A., 1998. Mutational analysis of creA, the mediator of carbon catabolite repression in Aspergillus nidulans. Ph.D. Thesis, University of Adelaide, Adelaide.
39. Shroff R.A., Lockington R.A., and Kelly J.M. Analysis of mutations in the creA gene involved in carbon catabolite repression in Aspergillus nidulans. Canadian Journal of Microbiology 42 (1996) 950-959
40. Shroff R.A., O'Conner S.M., Hynes M.J., Lockington R.A., and Kelly J.M. Null Alleles of creA, the regulator of carbon catabolite repression in Aspergillus nidulans. Fungal Genetics and Biology 22 (1997) 28-38
41. Strauss J., Horvath H.K., Abdallah B.M., Kindermann J., Mach R.L., and Kubicek C.P. The function of CreA, the carbon catabolite repressor of Aspergillus nidulans, is regulated at the transcriptional and post-transcriptional level. Molecular Microbiology 32 (1999) 168-178
42. Todd R.B., Lockington R.A., and Kelly J.M. The Aspergillus nidulans creC gene involved in carbon catabolite repression encodes a WD40 repeat protein. Molecular and General Genetics 263 (2000) 561-570
43. Treitel M.A., and Carlson M. Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein. Proceedings of the National Academy of Sciences of the United States of America 92 (1995) 3132-3136
44. Tzamarias D., and Struhl K. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 corepressor complex to differentially regulated promoters. Genes and Development 9 (1995) 821-831
45. Vautard G., Cotton P., and Fevre M. The glucose repressor CRE1 from Sclerotinia sclerotiorum is functionally related to CREA from Aspergillus nidulans but not to the Mig proteins from Saccharomyces cerevisiae. FEBS Letters 453 (1999) 54-58
46. Vautard-Mey G., and Fevre M. Mutation of a putative AMPK phosphorylation site abolishes the repressor activity but not the nuclear targeting of the fungal glucose regulator CRE1. Current Genetics 37 (2000) 328-332
47. Vautard-Mey G., Cotton P., and Fevre M. Expression and compartmentation of the glucose repressor CRE1 from the phytopathogenic fungus Sclerotinia sclerotiorum. European Journal of Biochemistry 266 (1999) 252-259