Novel cyclohexene derivatives as anti-sepsis agents: Synthetic studies and inhibition of NO and cytokine production

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3941-3958

  Yamada, Masami ^a   Ichikawa, Takashi ^a   Ii, Masayuki ^a   Itoh, Katsumi ^a   Tamura, Norikazu ^a   Kitazaki, Tomoyuki ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Benzylsulfone; Cyclohexene; Sepsis; TAK 242

Indexed keywords

6 [(2 CHLORO 4 FLUOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLIC ACID; ANTIINFECTIVE AGENT; CYCLOHEXENE DERIVATIVE; ETHYL 6 (BENZYLSULFANYL)CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(1 BENZOFURAN 2 YLMETHYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(1 BENZOFURAN 3 YLMETHYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(1 BENZOTHIOPHEN 2 YLMETHYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2 CHLORO 4 FLUOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2 CHLORO 4 FLUOROPHENOXY)SULFONYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2 CHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2 FLUORO 3 CHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2 FLUORO 5 CHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2 FLUOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2 THIENYLMETHYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2,3 DICHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2,3 DIFLUOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2,4 DICHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(2,4 DIFLUOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(3 CHLORO 4 FLUOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(3 CHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(3,4 DICHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(4 CHLORO 2 FLUOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(4 CHLOROBENZYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [(4 PYRIDYLMETHYL)SULFANYL]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 [[(2 CHLORO 4 FLUOROPHENYL)SULFONYL]AMINO]CYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 AZIDOCYCLOHEX 1 ENE 1 CARBOXYLATE; ETHYL 6 MERCAPTOCYCLOHEX 1 ENE 1 CARBOXYLATE; NITRIC OXIDE; TERT BUTYL 3 [[[2 (ETHOXYCARBONYL)CYCLOHEX 2 EN 1 YL]SULFANYL]METHYL] 1H INDOLE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTISEPSIS; ARTICLE; BIOLOGICAL ACTIVITY; CYTOKINE PRODUCTION; DRUG SYNTHESIS; ENZYME INHIBITION; PHYSICAL CHEMISTRY;

ANIMALS; CELL LINE; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-LINKING REAGENTS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXENES; DRUG DESIGN; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRIC OXIDE; SEPSIS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 41649118414     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.030     Document Type: Article

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