Differential and dose-dependent regulation of gene expression at the mid-hindbrain boundary by Ras-MAP kinase signaling

Brain Research

Volumn 1206, Issue , 2008, Pages 33-43

  Vennemann, Antje ^a   Agoston, Zsuzsa ^a   Schulte, Dorothea ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

Author keywords

Development; Hindbrain; Isthmic organizer; Midbrain; Ras MAP kinase pathway

Indexed keywords

RAS PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EN1 GENE; ENZYME ACTIVITY; EPHRIN A2 GENE; EPHRIN A5 GENE; EPHRIN B1 GENE; GENE EXPRESSION REGULATION; MARKER GENE; MEIS2 GENE; MESENCEPHALON; NONHUMAN; PAX2 GENE; PAX3 GENE; PAX5 GENE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WNT1 GENE;

ANIMALS; CHICK EMBRYO; EMBRYO, NONMAMMALIAN; FIBROBLAST GROWTH FACTORS; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MAP KINASE SIGNALING SYSTEM; MESENCEPHALON; MITOGEN-ACTIVATED PROTEIN KINASES; ORGANOGENESIS; PAIRED BOX TRANSCRIPTION FACTORS; RAS PROTEINS; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; WNT1 PROTEIN;

EID: 41649116597     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.01.100     Document Type: Article

References (60)

1. Adams K.A., Maida J.M., Golden J.A., and Riddle R.D. The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development 127 (2000) 1857-1867
2. Alexandre P., and Wassef M. The isthmic organizer links anteroposterior and dorsoventral patterning in the mid/hindbrain by generating roof plate structures. Development 130 (2003) 5331-5338
3. Alexandre P., Bachy I., Marcou M., and Wassef M. Positive and negative regulations by FGF8 contribute to midbrain roof plate developmental plasticity. Development 133 (2006) 2905-2913
4. Araki I., and Nakamura H. Engrailed defines the position of dorsal di-mesencephalic boundary by repressing diencephalic fate. Development 126 (1999) 5127-5135
5. Bally-Cuif L., and Wassef M. Ectopic induction and reorganization of Wnt-1 expression in quail/chick chimeras. Development 120 (1994) 3379-3394
6. Bally-Cuif L., Alvarado-Mallart R.M., Darnell D.K., and Wassef M. Relationship between Wnt-1 and En-2 expression domains during early development of normal and ectopic met-mesencephalon. Development 115 (1992) 999-1009
7. Blak A.A., Naserke T., Weisenhorn D.M., Prakash N., Partanen J., and Wurst W. Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Dev. Dyn. 233 (2005) 1023-1030
8. Blak A.A., Naserke T., Saarimaki-Vire J., Peltopuro P., Giraldo-Velasquez M., Vogt Weisenhorn D.M., Prakash N., Sendtner M., Partanen J., and Wurst W. Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Dev. Biol. 303 (2007) 231-243
9. Buckles G.R., Thorpe C.J., Ramel M.C., and Lekven A.C. Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formation. Mech. Dev. 121 (2004) 437-447
10. Canning C.A., Lee L., Irving C., Mason I., and Jones C.M. Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev. Biol. 305 (2007) 276-286
11. Corson L.B., Yamanaka Y., Lai K.M., and Rossant J. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130 (2003) 4527-4537
12. Crossley P.H., Martinez S., and Martin G.R. Midbrain development induced by FGF8 in the chick embryo. Nature 380 (1996) 66-68
13. Davis C.A., and Joyner A.L. Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development. Genes Dev. 2 (1988) 1736-1744
14. Epstein D.J., Vekemans M., and Gros P. Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 67 (1991) 767-774
15. Feig L.A., and Cooper G.M. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol. 8 (1988) 3235-3243
16. Funahashi J., Okafuji T., Ohuchi H., Noji S., Tanaka H., and Nakamura H. Role of Pax-5 in the regulation of a mid-hindbrain organizer's activity. Dev. Growth Differ. 41 (1999) 59-72
17. Gabay L., Seger R., and Shilo B.Z. In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277 (1997) 1103-1106
18. Hamburger V., and Hamilton H.L. A series of normal stages in the development of the chick embryo. J. Morph. 88 (1951) 49-&
19. Hidalgo-Sanchez M., Millet S., Simeone A., and Alvarado-Mallart R.M. Comparative analysis of Otx2, Gbx2, Pax2, Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain. Mech. Dev. 81 (1999) 175-178
20. Hindges R., McLaughlin T., Genoud N., Henkemeyer M., and O'Leary D.D. EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping. Neuron 35 (2002) 475-487
21. Hirata H., Tomita K., Bessho Y., and Kageyama R. Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J. 20 (2001) 4454-4466
22. Ikeya M., Lee S.M., Johnson J.E., McMahon A.P., and Takada S. Wnt signalling required for expansion of neural crest and CNS progenitors. Nature 389 (1997) 966-970
23. Itoh M., Kudoh T., Dedekian M., Kim C.H., and Chitnis A.B. A role for iro1 and iro7 in the establishment of an anteroposterior compartment of the ectoderm adjacent to the midbrain-hindbrain boundary. Development 129 (2002) 2317-2327
24. Jaszai J., Reifers F., Picker A., Langenberg T., and Brand M. Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity. Development 130 (2003) 6611-6623
25. Lee S.M., Danielian P.S., Fritzsch B., and McMahon A.P. Evidence that FGF8 signalling from the midbrain-hindbrain junction regulates growth and polarity in the developing midbrain. Development 124 (1997) 959-969
26. Lee K.J., Dietrich P., and Jessell T.M. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification. Nature 403 (2000) 734-740
27. Liu A., Losos K., and Joyner A.L. FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development 126 (1999) 4827-4838
28. Liu A., Li J.Y., Bromleigh C., Lao Z., Niswander L.A., and Joyner A.L. FGF17b and FGF18 have different midbrain regulatory properties from FGF8b or activated FGF receptors. Development 130 (2003) 6175-6185
29. Logan C., Wizenmann A., Drescher U., Monschau B., Bonhoeffer F., and Lumsden A. Rostral optic tectum acquires caudal characteristics following ectopic engrailed expression. Curr. Biol. 6 (1996) 1006-1014
30. Lun K., and Brand M. A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary. Development 125 (1998) 3049-3062
31. Mann F., Ray S., Harris W., and Holt C. Topographic mapping in dorsoventral axis of the Xenopus retinotectal system depends on signaling through ephrin-B ligands. Neuron 35 (2002) 461-473
32. Martinez S., Crossley P.H., Cobos I., Rubenstein J.L., and Martin G.R. FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development 126 (1999) 1189-1200
33. Matsunaga E., Araki I., and Nakamura H. Role of Pax3/7 in the tectum regionalization. Development 128 (2001) 4069-4077
34. McLaughlin T., Hindges R., Yates P.A., and O'Leary D.D. Bifunctional action of ephrin-B1 as a repellent and attractant to control bidirectional branch extension in dorsal-ventral retinotopic mapping. Development 130 (2003) 2407-2418
35. McMahon A.P., and Bradley A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62 (1990) 1073-1085
36. Meyers E.N., Lewandoski M., and Martin G.R. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat. Genet. 18 (1998) 136-141
37. Natoli T.A., Ellsworth M.K., Wu C., Gross K.W., and Pruitt S.C. Positive and negative DNA sequence elements are required to establish the pattern of Pax3 expression. Development 124 (1997) 617-626
38. Okafuji T., Funahashi J., and Nakamura H. Roles of Pax-2 in initiation of the chick tectal development. Brain Res. Dev. Brain Res. 116 (1999) 41-49
39. Olander S., Nordstrom U., Patthey C., and Edlund T. Convergent Wnt and FGF signaling at the gastrula stage induce the formation of the isthmic organizer. Mech. Dev. 123 (2006) 166-176
40. Pruitt S.C., Bussman A., Maslov A.Y., Natoli T.A., and Heinaman R. Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo. Gene Expr. Patterns 4 (2004) 671-685
41. Reifers F., Bohli H., Walsh E.C., Crossley P.H., Stainier D.Y., and Brand M. Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis. Development 125 (1998) 2381-2395
42. Rhinn M., Lun K., Luz M., Werner M., and Brand M. Positioning of the midbrain-hindbrain boundary organizer through global posteriorization of the neuroectoderm mediated by Wnt8 signaling. Development 132 (2005) 1261-1272
43. Ristoratore F., Carl M., Deschet K., Richard-Parpaillon L., Boujard D., Wittbrodt J., Chourrout D., Bourrat F., and Joly J.S. The midbrain-hindbrain boundary genetic cascade is activated ectopically in the diencephalon in response to the widespread expression of one of its components, the medaka gene Ol-eng2. Development 126 (1999) 3769-3779
44. Rowitch D.H., and McMahon A.P. Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1. Mech. Dev. 52 (1995) 3-8
45. Sato T., Araki I., and Nakamura H. Inductive signal and tissue responsiveness defining the tectum and the cerebellum. Development 128 (2001) 2461-2469
46. Sato T., Joyner A.L., and Nakamura H. How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development? Dev. Growth Differ. 46 (2004) 487-494
47. Sato T., and Nakamura H. The Fgf8 signal causes cerebellar differentiation by activating the Ras-ERK signaling pathway. Development 131 (2004) 4275-4285
48. Schulte D., and Cepko C.L. Two homeobox genes define the domain of EphA3 expression in the developing chick retina. Development 127 (2000) 5033-5045
49. Schulte D., Furukawa T., Peters M.A., Kozak C.A., and Cepko C.L. Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map. Neuron 24 (1999) 541-553
50. Schwarz M., Alvarez-Bolado G., Urbanek P., Busslinger M., and Gruss P. Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 14518-14523
51. Serls A.E., Doherty S., Parvatiyar P., Wells J.M., and Deutsch G.H. Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132 (2005) 35-47
52. Shamim H., Mahmood R., Logan C., Doherty P., Lumsden A., and Mason I. Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain. Development 126 (1999) 945-959
53. Storm E.E., Rubenstein J.L., and Martin G.R. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 1757-1762
54. Suzuki-Hirano A., Sato T., and Nakamura H. Regulation of isthmic Fgf8 signal by sprouty2. Development 132 (2005) 257-265
55. Swartz M.E., Eberhart J., Pasquale E.B., and Krull C.E. EphA4/ephrin-A5 interactions in muscle precursor cell migration in the avian forelimb. Development 128 (2001) 4669-4680
56. Trahey M., and McCormick F. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238 (1987) 542-545
57. Trokovic R., Trokovic N., Hernesniemi S., Pirvola U., Vogt Weisenhorn D.M., Rossant J., McMahon A.P., Wurst W., and Partanen J. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 22 (2003) 1811-1823
58. Walshe J., and Mason I. Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo. Mech. Dev. 90 (2000) 103-110
59. Wilkinson D.G., Bailes J.A., and McMahon A.P. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 50 (1987) 79-88
60. Wurst W., and Bally-Cuif L. Neural plate patterning: upstream and downstream of the isthmic organizer. Nat. Rev. Neurosci. 2 (2001) 99-108