Deletion of the SH gene from avian metapneumovirus has a greater impact on virus production and immunogenicity in Turkeys than deletion of the G gene or M2-2 open reading frame

Journal of General Virology

Volumn 89, Issue 2, 2008, Pages 525-533

  Ling, Roger ^a   Sinkovic, Sabrina ^a   Toquin, Didier ^b   Guionie, Olivier ^b   Eterradossi, Nicolas ^b   Easton, Andrew J ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b Healthy Pigs Production and Experimentation Section   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC RNA; ATTACHMENT PROTEIN G; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; AVIAN PNEUMOVIRUS; CELL CULTURE; CONTROLLED STUDY; GENE DELETION; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; NATURAL HOST; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; TURKEY (BIRD); VIROGENESIS; VIRUS GENE; VIRUS GENOME; VIRUS REPLICATION; ANIMAL; CELL LINE; GENETICS; IMMUNOLOGY; METAPNEUMOVIRUS; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRUS INFECTION;

ANIMALIA; AVES; AVIAN METAPNEUMOVIRUS; SUBGROUP A; SUBGROUP B; SUBGROUP C;

ANIMALS; ANTIBODIES, VIRAL; CELL LINE; GENE DELETION; GENES, VIRAL; METAPNEUMOVIRUS; OPEN READING FRAMES; PARAMYXOVIRIDAE INFECTIONS; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS;

EID: 41649115288     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.83309-0     Document Type: Article

References (28)

1. Bäyon-Auboyer, M.-H., Arnauld, C., Toquin, D. & Eterradossi, N. (2000). Nucleotide sequences of the F, L and G protein genes of two non-A/non-B avian pneumoviruses (APV) reveal a novel APV subgroup. J Gen Virol 81, 2723-2733.
2. Biacchesi, S., Skiadopoulos, M. H., Yang, L., Lamirande, E. W., Tran, K. C., Murphy, B. R., Collins, P. L. & Buchholz, U. J. (2004). Recombinant human metapneumovirus lacking the small hydrophobic SH and/ or attachment G glycoprotein: deletion of G yields a promising vaccine candidate. J Virol 78, 12877-12887.
3. Biacchesi, S., Pham, O. N., Skiadopoulos, M. H., Murphy, B. R., Collins, P. L. & Buchholz, U. J. (2005). Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. J Virol 79, 12608-12613.
4. Buchholz, U. J., Finke, S. & Conzelmann, K. K. (1999). Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter. J Virol 73, 251-259.
5. Bukreyev, A., Whitehead, S. S., Murphy, B. R. & Collins, P. L. (1997). Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. J Virol 71, 8973-8982.
6. Collins, P. L., Hill, M. G., Camargo, E., Grosfeld, H., Chanock, R. M. & Murphy, B. R. (1995). Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5′ proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development. Proc Natl Acad Sci U S A 92, 11563-11567.
7. Cook, J. K. (2000). Avian rhinotracheitis. Rev Sci Tech 19, 602-613.
8. Cook, J. K. A., Huggins, M. B., Orbell, S. J. & Senne, D. A. (1999). Preliminary antigenic characterization of an avian pneumovirus isolated from commercial turkeys in Colorado, USA. Avian Pathol 28, 607-618.
9. Eterradossi, N., Toquin, D., Guittet, M. & Bennejeart, G. (1995). Evaluation of different turkey rhinotracheitis viruses used as antigens for serological testing following live vaccination and challenge. Zentralbl Veterinarmed B 42, 175-186.
10. Gulonie, O., Toquin, D., Zwingelstein, F., Allée C., Sellal, E., Lemière, S. & Eterradossi, N. (2007). A laboratory evaluation of a quantitative real-time RT-PCR for the detection and identification of the four subgroups of avian metapneumoviruses. J Virol Methods 139, 150-158.
11. Herfst, S., de Graaf, M., Schickli, J. H., Tang, R. S., Kaur, J., Yang, C. F., Spaete, R. R., Haller, A. A., van den Hoogen, B. G. & other authors (2004). Recovery of human metapneumovirus genetic lineages A and B from cloned cDNA. J Virol 78, 8264-8270.
12. Jin, H., Cheng, X., Zhou, H. Z., Li, S. & Seddiqui, A. (2000). Respiratory syncytial virus that lacks open reading frame 2 of the M2 gene (M2-2) has altered growth characteristics and is attenuated in rodents. J Virol 74, 74-82.
13. Juhasz, K. & Easton, A. J. (1994). Extensive sequence variation in the attachment (G) protein of avian pneumovirus: evidence for two distinct subgroups. J Gen Virol 75, 2873-2880.
14. Li, J., Ling, R., Randhawa, J. S., Shaw, K., Davis, P. J., Juhasz, K., Pringle, C. R., Easton, A. J. & Cavanagh, D. (1996). Sequence of the nucleocapsid protein gene of subgroup A and B avian pneumoviruses. Virus Res 41, 185-191.
15. Liman, M. & Rautenschlein, S. (2007). Induction of local and systemic immune reactions following infection of turkeys with avian metapneumovirus (aMPV) subtypes A and B. Vet Immunol Immunopathol 115, 273-285.
16. Naylor, C. J., Brown, P. A., Edworthy, N., Ling, R., Jones, R. C., Savage, C. E. & Easton, A. J. (2004). Development of a reverse-genetics system for Avian pneumovirus demonstrates that the small hydrophobic (SH) and attachment (G) genes are not essential for virus viability. J Gen Virol 85, 3219-3227.
17. Randhawa, J. S., Wilson, S. D., Tolley, K. P., Cavanagh, D., Pringle, C. R. & Easton, A. J. (1986). Nucleotide sequence of the gene encoding the viral polymerase of avian pneumovirus. J Gen Virol 77, 3047-3051.
18. Techaarpornkul, S., Barretto, N. & Peeples, M. E. (2001). Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene. J Virol 75, 6825-6834.
19. Teng, M. N., Whitehead, S. S., Bermingham, A., St Claire, M., Elkins, W. R., Murphy, B. R. & Collins, P. L. (2000). Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees. J Virol 74, 9317-9321.
20. Tang, M. N., Whitehead, S. S. & Collins, P. L. (2001). Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo. Virology 289, 283-296.
21. Toquin, D., Eterradossi, N. & Guittet, M. (1996). Use of a related ELISA antigen for efficient TRT serological testing following live vaccination. Vet Rec 139, 71-72.
22. Toquin, D., Bäyon-Auboyer, M. H., Senne, D. & Eterradossi, N. (2000). Lack of antigenic relationship between early French and recent North American non-A non-B turkey rhinotracheitis viruses. Avian Dis 44, 977-982.
23. Toquin, D., de Boisseson, C., Beven, V., Senne, D. A. & Eterradossi, N. (2003). Subgroup C avian metapneumovirus (MPV) and the recently isolated human MPV exhibit a common organization but have extensive sequence divergence in their putative SH and G genes. J Gen Virol 84, 2169-2178.
24. Toquin, D., Guionie, O., Jestin, V., Zwingelstein, F., Allee, C. & Eterradossi, N. (2006). European and American subgroup C isolates of avian metapneumovirus belong to different genetic lineages. Virus Genes 32, 97-103.
25. van den Hoogen, B. G., de Jong, J. C., Groen, J., Kulken, T., de Groot R., Fouchier, R. A. & Osterhaus, A. D. (2001). A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 7, 719-724.
26. Whitehead, S. S., Bukreyev, A., Teng, M. N., Firestone, C. Y., St Claire, M., Elkins, W. R., Collins, P. L. & Murphy, B. R. (1999). Recombinant respiratory syncytial virus bearing a deletion of either the NS2 or SH gene is attenuated in chimpanzees. J Virol 73, 3438-3442.
27. Yu, O., Davis, P. J., Barrett, T., Binns, M. M., Boursnell, M. E. & Cavanagh, D. (1991). Deduced amino acid sequence of the fusion glycoprotein of turkey rhinotracheitis virus has greater identity with that of human respiratory syncytial virus, a pneumovirus, than that of paramyxoviruses and morbilliviruses. J Gen Virol 72, 75-81.
28. Yunus, A. S., Govindarajan, D., Huang, Z. & Samal, S. K. (2003). Deduced amino acid sequence of the small hydrophobic protein of US avian pneumovirus has greater identity with that of human metapneumovirus than those of non-US avian pneumoviruses. Virus Res 93, 91-97.