Motor learning transiently changes cortical somatotopy

NeuroImage

Volumn 40, Issue 4, 2008, Pages 1748-1754

  Molina Luna, Katiuska ^a   Hertler, Benjamin ^a   Buitrago, Manuel M ^a   Luft, Andreas R ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN MAPPING; CONTROLLED STUDY; CORRELATION ANALYSIS; FORELIMB; HINDLIMB; LEARNING; MEMORY; MOTOR CORTEX; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE; TRAINING;

ANIMALS; BRAIN MAPPING; CEREBRAL CORTEX; DATA INTERPRETATION, STATISTICAL; EPIDURAL SPACE; FORELIMB; LEARNING; LINEAR MODELS; MOTOR CORTEX; MOTOR SKILLS; PSYCHOMOTOR PERFORMANCE; RATS; RATS, LONG-EVANS; REGIONAL BLOOD FLOW;

EID: 41649111221     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2007.11.018     Document Type: Article

References (25)

1. Buitrago M.M., Ringer T., Schulz J.B., Dichgans J., and Luft A.R. Characterization of motor skill and instrumental learning time scales in a skilled reaching task in rat. Behav. Brain Res. 155 (2004) 249-256
2. Classen J., Liepert J., Wise S.P., Hallett M., and Cohen L.G. Rapid plasticity of human cortical movement representation induced by practice. J. Neurophysiol. 79 (1998) 1117-1123
3. Conner J.M., Culberson A., Packowski C., Chiba A.A., and Tuszynski M.H. Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron 38 (2003) 819-829
4. Elbert T., Pantev C., Wienbruch C., Rockstroh B., and Taub E. Increased cortical representation of the fingers of the left hand in string players. Science 270 (1995) 305-307
5. Hikosaka O., Nakamura K., Sakai K., and Nakahara H. Central mechanisms of motor skill learning. Curr. Opin. Neurobiol. 12 (2002) 217-222
6. Huntley G.W., and Jones E.G. Relationship of intrinsic connections to forelimb movement representations in monkey motor cortex: a correlative anatomic and physiological study. J. Neurophysiol. 66 (1991) 390-413
7. Ioffe M.E. Brain mechanisms for the formation of new movements during learning: the evolution of classical concepts. Neurosci. Behav. Physiol. 34 (2004) 5-18
8. Karni A., Meyer G., Jezzard P., Adams M.M., Turner R., and Ungerleider L.G. Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature 377 (1995) 155-158
9. Kisley M.A., and Gerstein G.L. Trial-to-trial variability and state-dependent modulation of auditory-evoked responses in cortex. J. Neurosci. 19 (1999) 10451-10460
10. Kleim J.A., Barbay S., and Nudo R.J. Functional reorganization of the rat motor cortex following motor skill learning. J. Neurophysiol. 80 (1998) 3321-3325
11. Kleim J.A., Hogg T.M., VandenBerg P.M., Cooper N.R., Bruneau R., and Remple M. Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning. J. Neurosci. 24 (2004) 628-633
12. Kleim J.A., Bruneau R., Calder K., Pocock D., VandenBerg P.M., MacDonald E., Monfils M.H., Sutherland R.J., and Nader K. Functional organization of adult motor cortex is dependent upon continued protein synthesis. Neuron 40 (2003) 167-176
13. Littell, et al. SAS for Linear Models. 4th ed. (2002), Wiley, Hoboken, NJ
14. Luft A.R., Buitrago M.M., Kaelin-Lang A., Dichgans J., and Schulz J.B. Protein synthesis inhibition blocks consolidation of an acrobatic motor skill. Learn. Mem. 11 (2004) 379-382
15. Luft A.R., Buitrago M.M., Ringer T., Dichgans J., and Schulz J.B. Motor skill learning depends on protein synthesis in motor cortex after training. J. Neurosci. 24 (2004) 6515-6520
16. Maynard E.M., Hatsopoulos N.G., Ojakangas C.L., Acuna B.D., Sanes J.N., Normann R.A., and Donoghue J.P. Neuronal interactions improve cortical population coding of movement direction. J. Neurosci. 19 (1999) 8083-8093
17. Molina-Luna K., Buitrago M.M., Hertler B., Schubring M., Haiss F., Nisch W., Schulz J.B., and Luft A.R. Cortical stimulation mapping using epidurally implanted thin-film microelectrode arrays. J. Neurosci. Methods 161 1 (2007) 118-125
18. Monfils M.H., Plautz E.J., and Kleim J.A. In search of the motor engram: motor map plasticity as a mechanism for encoding motor experience. Neuroscientist 11 (2005) 471-483
19. Monfils M.H., VandenBerg P.M., Kleim J.A., and Teskey G.C. Long-term potentiation induces expanded movement representations and dendritic hypertrophy in layer V of rat sensorimotor neocortex. Cereb. Cortex 14 (2004) 586-593
20. Nudo R.J., Milliken G.W., Jenkins W.M., and Merzenich M.M. Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys. J. Neurosci. 16 (1996) 785-807
21. Pascual-Leone A., Nguyet D., Cohen L.G., Brasil-Neto J.P., Cammarota A., and Hallett M. Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. J. Neurophysiol. 74 (1995) 1037-1045
22. Plautz E.J., Milliken G.W., and Nudo R.J. Effects of repetitive motor training on movement representations in adult squirrel monkeys: role of use versus learning. Neurobiol. Learn Mem. 74 (2000) 27-55
23. Rioult-Pedotti M.S., Friedman D., and Donoghue J.P. Learning-induced LTP in neocortex. Science 290 (2000) 533-536
24. Sanes J.N., Wang J., and Donoghue J.P. Immediate and delayed changes of rat motor cortical output representation with new forelimb configurations. Cereb. Cortex 2 (1992) 141-152
25. VandenBerg P.M., Hogg T.M., Kleim J.A., and Whishaw I.Q. Long-Evans rats have a larger cortical topographic representation of movement than Fischer-344 rats: a microstimulation study of motor cortex in naive and skilled reaching-trained rats. Brain Res. Bull. 59 (2002) 197-203