Protein synthesis inhibition blocks consolidation of an acrobatic motor skill

Learning and Memory

Volumn 11, Issue 4, 2004, Pages 379-382

  Luft, Andreas R ^a   Buitrago, Manuel M ^a   Kaelin Lang, Alain ^b   Dichgans, Johannes ^a   Schulz, Jörg B ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; LEARNING; LOCOMOTION; MALE; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; REWARD; SKILL; TASK PERFORMANCE; VELOCITY;

EID: 4043134718     PISSN: 10720502     EISSN: None     Source Type: Journal    
DOI: 10.1101/lm.72604     Document Type: Article

References (14)

1. Brandon, E.P., Logue, S.F., Adams, M.R., Qi, M., Sullivan, S.P., Matsumoto, A.M., Dorsa, D.M., Wehner, J.M., McKnight, G.S., and Idzerda, R.L. 1998. Defective motor behavior and neural gene expression in RIIβ-protein kinase A mutant mice. J. Neurosci. 18: 3639-3649.
2. Buitrago, M., Schulz, J., Dichgans, J., and Luft, A. 2004. Short and long-term motor skill learning in an accelerated rotarod training paradigm. Neurobiol. Learn. Mem. 81: 211-216.
3. Cariga, P., Catley, M., Nowicky, A.V., Savic, G., Ellaway, P.H., and Davey, N.J. 2002. Segmental recording of cortical motor evoked potentials from thoracic paravertebral myotomes in complete spinal cord injury. Spine 27: 1438-1443.
4. Chiba, A., Hiruma, S., Hashimoto, S., and Inase, M. 2000. Changes in spinal cord function caused by injuries at different levels of the lumbar spinal cord. Neuroreport 11: 2163-2166.
5. Davey, K., Epstein, C.M., George, M.S., and Bohning, D.E. 2003. Modeling the effects of electrical conductivity of the head on the induced electric field in the brain during magnetic stimulation. Clin. Neurophysiol. 114: 2204-2209.
6. Davis, H.P. and Squire, L.R. 1984. Protein synthesis and memory: A review. Psychol. Bull. 96: 518-559.
7. Frey, U., Huang, Y.Y., and Kandel, E.R. 1993. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260: 1661-1664.
8. Gould, T.J., Rowe, W.B., Heman, K.L., Mesches, M.H., Young, D.A., Rose, G.M., and Bickford, P.C. 2002. Effects of hippocampal lesions on patterned motor learning in the rat. Brain Res. Bull. 58: 581-586.
9. Gupta, R.C. and Dettbarn, W.D. 1987. Interaction of cycloheximide and diisopropylphosphorofluoridate (DFP) during subchronic administration in rat. Toxicol. Appl. Pharmacol. 90: 52-59.
10. Hikosaka, O., Nakamura, K., Sakai, K., and Nakahara, H. 2002. Central mechanisms of motor skill learning. Curr. Opin. Neurobiol. 12: 217-222.
11. Kleim, J.A., Bruneau, R., Calder, K., Pocock, D., VandenBerg, P.M., MacDonald, E., Monfils, M.H., Sutherland, R.J., and Nader, K. 2003. Functional organization of adult motor cortex is dependent upon continued protein synthesis. Neuron 40: 167-176.
12. Pavlik, A. and Teisinger, J. 1980. Effect of cycloheximide administered to rats in early postnatal life: Prolonged inhibition of DNA synthesis in the developing brain. Brain Res. 192: 531-541.
13. Snider, B.J., Du, C., Wei, L., and Choi, D.W. 2001. Cycloheximide reduces infarct volume when administered up to 6 h after mild focal ischemia in rats. Brain Res. 917: 147-157.
14. Taniguchi, S., Tani, T., Ushida, T., and Yamamoto, H. 2002. Motor evoked potentials elicited from erector spinae muscles in patients with thoracic myelopathy. Spinal Cord 40: 567-573.