Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients

JAMA

Volumn 299, Issue 13, 2008, Pages 1541-1542

  Barletta, Jeffrey F ^a   Devlin, John W ^b  

^a SPECTRUM HEALTH   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; LORAZEPAM; PROPOFOL; HYPNOTIC SEDATIVE AGENT;

ARTIFICIAL VENTILATION; BRAIN DYSFUNCTION; CLINICAL TRIAL; COMA; CONSCIOUSNESS DISORDER; DELIRIUM; DRUG EFFECT; DRUG HALF LIFE; HUMAN; LETTER; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; SEDATION; CHEMICALLY INDUCED DISORDER; CONSCIOUS SEDATION; METHODOLOGY; NOTE;

CONSCIOUS SEDATION; DELIRIUM; DEXMEDETOMIDINE; HUMANS; HYPNOTICS AND SEDATIVES; LORAZEPAM; RESEARCH DESIGN; RESPIRATION, ARTIFICIAL;

EID: 41649104916     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.299.13.1541     Document Type: Letter

References (5)

1. Pandharipande PP, Pun BT, Herr DL, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298(22):2644-2653.
2. Ouimet S, Kananagh BP, Gottfried SB, et al. Incidence, risk factors and consequences of ICU delirium. Intensive Care Med. 2007;33(1):66-73.
3. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342(20):1471-1477.
4. Carson SS, Kress JP, Rodgers JE, et al. A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med. 2006;34(5):1326-1332.
5. Tanios MA, Devlin JW, Epstein SK. Perceived barriers to implementing strategy of daily interruption of sedative in the intensive care unit for critically ill patients. Am J Respir Crit Care Med. 2005;171:A793.