High-affinity uranyl-specific antibodies suitable for cellular imaging

Chemical Research in Toxicology

Volumn 21, Issue 2, 2008, Pages 349-357

  Reisser Rubrecht, Laetitia ^a,b   Torne Celer, Caroline ^a   Rénier, Wendy ^a   Averseng, Olivier ^a   Plantevin, Sophie ^a   Quéméneur, Eric ^a   Bellanger, Laurent ^a   Vidaud, Claude ^a  

^a CEA Marcoule   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CASEIN; CUPRIC ION; EPITOPE; FERRIC ION; METAL ION; MONOCLONAL ANTIBODY; URANIUM; ZINC ION; CHELATING AGENT; URANIUM DERIVATIVE;

ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; CELL LABELING; CROSS REACTION; FLUORESCENCE; HUMAN; HUMAN CELL; IMAGING; ANTIBODY COMBINING SITE; CHEMISTRY; CYTOLOGY; FLOW CYTOMETRY; HYBRIDOMA; IMMUNOLOGY; KIDNEY; KIDNEY PROXIMAL TUBULE; METABOLISM; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; CELL LINE, TUMOR; CHELATING AGENTS; FLOW CYTOMETRY; HUMANS; HYBRIDOMAS; KIDNEY; KIDNEY TUBULES, PROXIMAL; URANIUM COMPOUNDS;

EID: 41649104900     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700215e     Document Type: Article

References (37)

1. Zamora, M. L., Tracy, B. L., Zielinski, J. M., Meyerhof, D. P., and Moss, M. A. (1998) Chronic ingestion of uranium in drinking water: A study of kidney bioeffects in humans. Toxicol. Sci. 43, 68-77.
2. Kurttio, P., Auvinen, A., Salonen, L., Saha, H., Pekkanen, J., Makelainen, I., Vaisanen, S. B., Penttila, I. M., and Komulainen, H. (2002) Renal effects of uranium in drinking water. Environ. Health Perspect. 110, 337-342.
3. Kurttio, P., Komulainen, H., Leino, A., Salonen, L., Auvinen, A., and Saha, H. (2005) Bone as a possible target of chemical toxicity of natural uranium in drinking water. Environ. Health Perspect. 113, 68-72.
4. Ananyev, G. M., Murphy, A., Abe, Y., and Dismukes, G. C. (1999) Remarkable affinity and selectivity for Cs+ and uranyl (UO22+) binding to the manganese site of the apo-water oxidation complex of photosystem II. Biochemistry 38, 7200-7209.
5. MacCordick, H. J. T. F., Meyer, J. P., and Gelus, D. (1997) Interaction of uranyl ions with snake venom proteins from Lachesis muta muta. J. Radioanal. Nucl. Chem. 223, 187-191.
6. Pible, O., Guilbaud, P., Pellequer, J. L., Vidaud, C., and Quemeneur, E. (2006) Structural insights into protein-uranyl interaction: Towards an in silico detection method. Biochimie 1631-1638.
7. Vidaud, C., Gourion-Arsiquaud, S., Rollin-Genetet, F., Torne-Celer, C., Plantevin, S., Pible, O., Berthomieu, C., and Quemeneur, E. (2007) Structural consequences of binding of UO(2)(2+) to apotransferrin: Can this protein account for entry of uranium into human cells? Biochemistry 46, 2215-2226.
8. Griem, P., and Gleichmann, E. (1995) Metal ion induced autoimmunity. Curr. Opin. Immunol. 7, 831-838.
9. Clarke, S. M. (1991) A novel enzyme-linked immunosorbent assay (ELISA) for the detection of beryllium antibodies. J. Immunol. Methods 137, 65-72.
10. Reardan, D. T., Meares, C. F., Goodwin, D. A., McTigue, M., David, G. S., Stone, M. R., Leung, J. P., Bartholomew, R. M., and Frincke, J. M. (1985) Antibodies against metal chelates. Nature 316, 265-268.
11. Goodwin, D. A., and Meares, C. F. (2001) Advances in pretargeting biotechnology. Biotechnol. Adv. 19, 435-450.
12. Corneillie, T. M., Whetstone, P. A., and Meares, C. F. (2006) Irreversibly binding anti-metal chelate antibodies: Artificial receptors for pretargeting. J. Inorg. Biochem. 100, 882-890.
13. Corneillie, T. M., Lee, K. C., Whetstone, P. A., Wong, J. P., and Meares, C. F. (2004) Irreversible engineering of the multielement-binding antibody 2D12.5 and its complementary ligands. Bioconjugate Chem. 15, 1392-1402.
14. Sharkey, R. M., Karacay, H., Chang, C. H., McBride, W. J., Horak, I. D., and Goldenberg, D. M. (2005) Improved therapy of non-Hodgkin's lymphoma xenografts using radionuclides pretargeted with a new anti-CD20 bispecific antibody. Leukemia 19, 1064-1069.
15. Rossi, E. A., Sharkey, R. M., McBride, W., Karacay, H., Zeng, L., Hansen, H. J., Goldenberg, D. M., and Chang, C. H. (2003) Development of new multivalent-bispecific agents for pretargeting tumor localization and therapy. Clin. Cancer Res. 9, 3886S-3896S.
16. McBride, W. J., Zanzonico, P., Sharkey, R. M., Noren, C., Karacay, H., Rossi, E. A., Losman, M. J., Brard, P. Y., Chang, C. H., Larson, S. M., and Goldenberg, D. M. (2006) Bispecific antibody pretargeting PET (immunoPET) with an 124I-labeled hapten-peptide. J. Nucl. Med. 47, 1678-1688.
17. Karacay, H., McBride, W. J., Griffiths, G. L., Sharkey, R. M., Barbet, J., Hansen, H. J., and Goldenberg, D. M. (2000) Experimental pretargeting studies of cancer with a humanized anti-CEA x murine anti-[In-DTPA] bispecific antibody construct and a (99m)Tc-/(188)Re-labeled peptide. Bioconjugate Chem. 11, 842-854.
18. Griffiths, G. L., Chang, C. H., McBride, W. J., Rossi, E. A., Sheerin, A., Tejada, G. R., Karacay, H., Sharkey, R. M., Horak, I. D., Hansen, H. J., and Goldenberg, D. M. (2004) Reagents and methods for PET using bispecific antibody pretargeting and 68Ga-radiolabeled bivalent hapten-peptide-chelate conjugates. J. Nucl. Med. 45, 30-39.
19. Cardillo, T. M., Karacay, H., Goldenberg, D. M., Yeldell, D., Chang, C. H., Modrak, D. E., Sharkey, R. M., and Gold, D. V. (2004) Improved targeting of pancreatic cancer: experimental studies of a new bispecific antibody, pretargeting enhancement system for immunoscintigraphy. Clin. Cancer Res. 10, 3552-3561.
20. Wylie, D. E., Lu, D., Carlson, L. D., Carlson, R., Babacan, K. F., Schuster, S. M., and Wagner, F. W. (1992) Monoclonal antibodies specific for mercuric ions. Proc. Natl. Acad. Sci. U.S.A. 89, 4104-4108.
21. Love, R. A., Villafranca, J. E., Aust, R. M., Nakamura, K. K., Jue, R. A., Major, J. G., Jr., Radhakrishnan, R., and Butler, W. F. (1993) How the anti-(metal chelate) antibody CHA255 is specific for the metal ion of its antigen: X-ray structures for two Fab′/hapten complexes with different metals in the chelate. Biochemistry 32, 10950-10959.
22. Blake, D. A., Jones, R. M., Blake, R. C., 2nd, Pavlov, A. R., Darwish, I. A., and Yu, H. (2001) Antibody-based sensors for heavy metal ions. Biosens. Bioelectron. 16, 799-809.
23. Blake, D. A., Chakrabarti, P., Khosraviani, M., Hatcher, F. M., Westhoff, C. M., Goebel, P., Wylie, D. E., and Blake, R. C., 2nd (1996) Metal binding properties of a monoclonal antibody directed toward metal-chelate complexes. J. Biol. Chem. 271, 27677-27685.
24. Blake, D. A., Pavlov, A. R., Yu, H., Kohsraviani, M., Ensley, H. E., and Blake, R. C. (2001) Antibodies and antibody-based assays for hexavalent uranium. Anal. Chim. Acta 444, 3-11.
25. Blake, I. R., Pavlov, A. R., Khosraviani, M., Ensley, H. E., Kiefer, G. E., Yu, H., Li, X., and Blake, D. A. (2004) Novel monoclonal antibodies with specificity for chelated uranium(VI): Isolation and binding properties. Bioconjugate Chem. 15, 1125-1136.
26. Vidaud, C., Dedieu, A., Basset, C., Plantevin, S., Dany, I., Pible, O., and Quemeneur, E. (2005) Screening of human serum proteins for uranium binding. Chem. Res. Toxicol. 18, 946-953.
27. Kearney, J. F., Radbruch, A., Liesegang, B., and Rajewsky, K. (1979) A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123, 1548-1550.
28. Kohler, G., and Milstein, C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497.
29. Myszka, D. G., Jonsen, M. D., and Graves, B. J. (1998) Equilibrium analysis of high affinity interactions using BIACORE. Anal. Biochem. 265, 326-330.
30. Safsten, P., Klakamp, S. L., Drake, A. W., Karlsson, R., and Myszka, D. G. (2006) Screening antibody-antigen interactions in parallel using Biacore A100. Anal. Biochem. 353, 181-190.
31. Sutton, M., and Burastero, S. R. (2004) Uranium(VI) solubility and speciation in simulated elemental human biological fluids. Chem. Res. Toxicol. 17, 1468-1480.
32. Carriere, M., Thiebault, C., Milgram, S., Avoscan, L., Proux, O., and Gouget, B. (2006) Citrate does not change uranium chemical speciation in cell culture medium but increases its toxicity and accumulation in NRK-52E cells. Chem. Res. Toxicol. 19, 1637-1642.
33. Khosraviani, M., Blake, R. C., 2nd, Pavlov, A. R., Lorbach, S. C., Yu, H., Delehanty, J. B., Brechbiel, M. W., and Blake, D. A. (2000) Binding properties of a monoclonal antibody directed toward lead-chelate complexes. Bioconjugate Chem. 11, 267-277.
34. Delehanty, J. B., Jones, R. M., Bishop, T. C., and Blake, D. A. (2003) Identification of important residues in metal-chelate recognition by monoclonal antibodies. Biochemistry 42, 14173-14183.
35. Ortega, R. (2005) Chemical elements distribution in cells. Nucl. Instrum. Methods Phys. Res., Sect. B 231, 218-223.
36. Lobinski, R., Moulin, C., and Ortega, R. (2006) Imaging and speciation of trace elements in biological environment. Biochimie 88, 1591-1604.
37. Odorico, M., Teulon, J. M., Bessou, T., Vidaud, C., Bellanger, L., Chen, S. W., Quemeneur, E., Parot, P., and Pellequer, J. L. (2007) Energy landscape of chelated uranyl - Antibody interactions by dynamic force spectroscopy. Biophys. J. 93, 645-654.