Experimental pretargeting studies of cancer with a humanized anti-CEA x murine anti-[In-DTPA] bispecific antibody construct and a (99m)Tc-/188Re-labeled peptide

Bioconjugate Chemistry

Volumn 11, Issue 6, 2000, Pages 842-854

  Karacay, H ^a   McBride, W J ^a   Griffiths, G L ^a   Sharkey, R M ^b   Barbet, J ^c   Hansen, H J ^a   Goldenberg, D M ^b  

^a IMMUNOMEDICS INC   (United States)

^b GARDEN STATE CANCER CENTER   (United States)

^c IBC Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGENS; DISEASES; INDIUM; RADIOISOTOPES; RADIOTHERAPY; TUMORS;

CARCINOEMBRYONIC ANTIGEN; CLINICAL APPLICATION; DIVALENTS; FAB' FRAGMENT; IN-VITRO; NOVEL PEPTIDES; SINGLE-DOSE; SYNTHESISED; TWO-STEP APPROACH; VITRO AND IN VIVO;

PEPTIDES;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0033657792     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0000379     Document Type: Article

References (54)

1. 90Y radioimmunotherapy in a mouse xenograft model
2. Two-step strategies for the diagnosis and treatment of cancer with bioconjugates
3. Radioimmunodetection of medullary thyroid carcinoma using indium-111 bivalent hapten and anti-CEA x anti-DTPA-indium bispecific antibody
4. Reduction in the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives
5. Pretargeting of renal cell carcinoma: Improved tumor targeting with a bivalent chelate
6. In vitro evaluation of DNA-DNA hybridization as a two-step approach in radioimmunotherapy of cancer
7. Engineering antibodies for imaging and therapy
8. 2 fragments
9. Biochemical modifications of avidin improve pharmacokinetics and biodistribution, and reduce immunogenicity
10. Design and production of novel tetravalent bispecific antibodies
11. Three-step radioimmunotherapy with yttrium-90 biotin: Dosimetry and pharmacokinetics in cancer patients
12. Selective cleavage of the allyl and allyloxycarbonyl groups through palladium-catalyzed hydrostannolysis with tributyltin Hydride. Application to the selective protection-deprotection of amino acid derivatives and in peptide synthesis
13. Phage-library-derived human anti-TETA and anti-DOTA scFv for pretargeting RIT
14. New anti-Cu-TETA and anti-Y-DOTA monoclonal antibodies for potential use in the pretargeted delivery of radiopharmaceuticals to tumors
15. Therapy for colon carcinoma xenografts with bispecific antibody-targeted, iodine-131-labeled bivalent hapten
16. Delivery of therapeutic doses of radioiodine using bispecific antibody-targeted bivalent haptens: A comparative pharmacokinetic and dosimetry study
17. 131I-labeled bivalent haptens
18. 2 antibody containing thioether-linked Fab'γ fragments
19. GW-39: A new human tumor serially transplantable in the golden hamster
20. Carcinoembryonic antigen present in human colonic neopasms serially propagated in hamsters
21. Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens
22. The preparation of I-131 labeled human growth hormone of high specifc radioactivity
23. Direct radiolabeling of monoclonal antibodies with generator-produced rhenium-188 for radioimmunotherapy: Labeling and animal biodistribution studies
24. Preclinical evaluation of an 'instant' (99m)Tc-labeling kit for antibody imaging
25. 90Y from cyclic and acyclic ligand-antibody complexes
26. Delivery of radionuclides to pretargeted monoclonal antibodies using dihydrofolate reductase and methotrexate in an affinity system
27. Investigations of avidin and biotin for imaging applications
28. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides
29. Development of a streptavidin-anti-carcinoembryonic antigen antibody, radiolabeled biotin pretargeting method for radioimmunotherapy of colorectal cancer: Reagent development
30. Processing of reactor-produced tungsten-188 for fabrication of clinical scale alumina-based tungsten-188/rhenium-188 generators
31. In vitro and in vivo targeting of radiolabeled monovalent and divalent haptens with dual specificity monoclonal antibody conjugates: Enhanced divalent hapten affinity for cell-bound antibody conjugate
32. Targeting of indium-111-labeled bivalent hapten to human melanoma mediated by bispecific monoclonal antibody conjugates: Imaging of tumors hosted in nude mice
33. Bispecific monoclonal antibody-mediated targeting of an indium-111-labeled DTPA dimer to primary colorectal tumors: Pharmacokinetics, biodistribution, scintigraphy and immune response
34. Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2
35. 1 immunoglobulin, hLL2, and its fragments
36. Mimicry of a carcinoembryonic antigen epitope by a rat monoclonal anti-idiotype antibody
37. Generation and monitoring of cell lines producing humanized antibodies
38. Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions
39. In vivo labeling of biotinylated monoclonal antibodies by radioactive avidin: A strategy to increase tumor radiolocalization
40. A centrifuged column procedure for the measurement of ligand binding by beef heart F1. Part G
41. Rapid blood clearance of mouse IgG2a and human IgG1 in many nude and nu/+ mouse strains is due to low IgG2a serum concentrations
42. Pharmacokinetics and biodistribution of radiolabeled avidin, streptavidin and biotin
43. Imaging osteomyelitis with streptavidin and indium-111-labeled biotin
44. Multistep tumor targeting in nude mice using bispecific antibodies and a gallium chelate suitable for immunoscintigraphy with positron emission tomography
45. Biodistribution and radiation dose estimates for yttrium- and iodine-labeled monoclonal antibody IgG and fragments in nude mice bearing human colonic tumor xenografts
46. Rapid blood clearance of IgG2a and IgG2b in nude mice
47. Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies
48. Development of a streptavidin-anticarcinoembryonic antigen antibody, radiolabeled biotin pre-targeting method for radioimmunotherapy of colorectal cancer. Studies in a human colon cancer xenograft model
49. 2 fragments of an anti-CEA murine monoclonal antibody (Immu-14)
50. Absorbed fractions for electrons and beta particles in small spheres
51. Bifunctional antibody: A binary radiopharmaceutical delivery system for imaging colorectal carcinoma
52. Two-step radioimmunoscintigraphy for nonsmall cell lung cancer staging using a bispecific anti-CEA/anti-indium-DTPA antibody and an indium-111-labeled DTPA dimer
53. Radioimmunotherapy of small cell lung carcinoma with the two-step method using a bispecific anti-carcinoembryonic antigen/antidiethylenetriaminepentaacetic acid (DTPA) antibody and iodine-131 Di-DTPA hapten: Results of a Phase I/II trial
54. Streptavidin in antibody pretargeting. Comparison of a recombinant streptavidin with two streptavidin mutant proteins and two commercially available streptavidin proteins